Gene: ENSMUSG00000024610 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000024610
Transcript Identifier
ENSMUST00000167610
Gene Type
Coding gene
Location
18 : 60803934-60812162 : positive

Family Information

Homologous gene family
HOM03P011525
(7 genes in 4 species)
specific family

Descriptions

gene_descr
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)

Identifiers

Type Value
UniprotP04441
UniprotQ3U4Q8
MGI96534

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000187
IEA
Genome Projectactivation of MAPK activity
GO:0001516
ISS, ISO
IEA
Genome Projectprostaglandin biosynthetic process
GO:0001961
IMP
ISO
IEA
Genome Projectpositive regulation of cytokine-mediated signaling pathway
GO:0002250
IEA
Genome Projectadaptive immune response
GO:0002376
IEA
Genome Projectimmune system process
GO:0002606
IDA
Genome Projectpositive regulation of dendritic cell antigen processing and presentation
GO:0002792
ISO
IEA
Genome Projectnegative regulation of peptide secretion
GO:0002821
NAS
Genome Projectpositive regulation of adaptive immune response
GO:0002830
IMP
Genome Projectpositive regulation of type 2 immune response
GO:0002906
IMP
Genome Projectnegative regulation of mature B cell apoptotic process
GO:0006461
IDA
Genome Projectprotein complex assembly
GO:0006886
IDA, IMP
IEA
Genome Projectintracellular protein transport
GO:0006952
IMP
Genome Projectdefense response
GO:0006955
IEA
Genome Projectimmune response
GO:0007165
ISO
IEA
Genome Projectsignal transduction
GO:0008283
ISS, ISO
IEA
Genome Projectcell proliferation
GO:0016064
IMP
Genome Projectimmunoglobulin mediated immune response
GO:0019882
IDA, IMP
IEA
Genome Projectantigen processing and presentation
GO:0019886
IMP
Genome Projectantigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0030890
ISO
IEA
Genome Projectpositive regulation of B cell proliferation
GO:0035691
IDA
Genome Projectmacrophage migration inhibitory factor signaling pathway
GO:0043066
ISS, ISO
IEA
Genome Projectnegative regulation of apoptotic process
GO:0043518
IMP
ISO
IEA
Genome Projectnegative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045059
IMP
Genome Projectpositive thymic T cell selection
GO:0045060
IMP
Genome Projectnegative thymic T cell selection
GO:0045089
IC
Genome Projectpositive regulation of innate immune response
GO:0045581
IMP
Genome Projectnegative regulation of T cell differentiation
GO:0045582
IMP
Genome Projectpositive regulation of T cell differentiation
GO:0048146
ISO
IEA
Genome Projectpositive regulation of fibroblast proliferation
GO:0050731
IMP
ISO
IEA
Genome Projectpositive regulation of peptidyl-tyrosine phosphorylation
GO:0051085
IDA, IMP
Genome Projectchaperone mediated protein folding requiring cofactor
GO:0060907
IDA
Genome Projectpositive regulation of macrophage cytokine production
GO:0070374
IMP
ISO
IEA
Genome Projectpositive regulation of ERK1 and ERK2 cascade
GO:0090023
IDA
Genome Projectpositive regulation of neutrophil chemotaxis
GO:1902166
IMP
ISO
IEA
Genome Projectnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:2000343
IDA
Genome Projectpositive regulation of chemokine (C-X-C motif) ligand 2 production
GO:0019221
ISO
IEA
Genome Projectcytokine-mediated signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001540
ISO
IEA
Genome Projectbeta-amyloid binding
GO:0004896
IMP
ISO
IEA
Genome Projectcytokine receptor activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0019955
IDA
ISS, ISO
IEA
Genome Projectcytokine binding
GO:0023026
ISO
IEA
Genome ProjectMHC class II protein complex binding
GO:0035718
ISO
IEA
Genome Projectmacrophage migration inhibitory factor binding
GO:0042289
IPI
IEA
Genome ProjectMHC class II protein binding
GO:0042658
ISO
IEA
Genome ProjectMHC class II protein binding, via antigen binding groove
GO:0044183
ISO
IEA
Genome Projectprotein binding involved in protein folding
GO:0050998
IPI
Genome Projectnitric-oxide synthase binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005764
IDA
Genome Projectlysosome
GO:0005770
IDA
Genome Projectlate endosome
GO:0005771
IDA
Genome Projectmultivesicular body
GO:0005773
ISO
IEA
Genome Projectvacuole
GO:0005783
IDA
Genome Projectendoplasmic reticulum
GO:0005794
IDA
Genome ProjectGolgi apparatus
GO:0005886
IDA, IMP
Genome Projectplasma membrane
GO:0005887
TAS
Genome Projectintegral component of plasma membrane
GO:0009897
IDA
Genome Projectexternal side of plasma membrane
GO:0009986
ISO
IEA
Genome Projectcell surface
GO:0016020
ISO
IEA
Genome Projectmembrane
GO:0016021
ISO
IEA
Genome Projectintegral component of membrane
GO:0035692
IDA
ISO
IEA
Genome Projectmacrophage migration inhibitory factor receptor complex
GO:0035693
IDA
Genome ProjectNOS2-CD74 complex
GO:0070062
ISO
IEA
Genome Projectextracellular exosome
GO:0042613
IDA
Genome ProjectMHC class II protein complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000716Thyroglobulin type-1
IPR011988MHC class II-associated invariant chain, trimerisation
IPR015386MHC class II-associated invariant chain/CLIP, MHC II-interacting
IPR022339MHC class II-associated invariant chain

No MapMan annotations defined for this gene.