Gene: ENSMUSG00000024563 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000024563
Transcript Identifier
ENSMUST00000025453
Gene Type
Coding gene
Location
18 : 76262492-76304730 : positive

Family Information

Homologous gene family
HOM03P003942
(24 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P007471
(11 genes in 4 species)
specific family

Descriptions

gene_descr
SMAD family member 2

Identifiers

Type Value
UniprotQ62432
MGI108051

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001657
IEP
Genome Projectureteric bud development
GO:0001701
IMP, IGI
Genome Projectin utero embryonic development
GO:0001706
IMP
Genome Projectendoderm formation
GO:0001707
IMP
Genome Projectmesoderm formation
GO:0006351
IEA
Genome Projecttranscription, DNA-templated
GO:0006355
IEA
Genome Projectregulation of transcription, DNA-templated
GO:0006366
ISO
IEA
Genome Projecttranscription from RNA polymerase II promoter
GO:0006468
IDA
Genome Projectprotein phosphorylation
GO:0007179
IDA, IGI
ISO
IEA
Genome Projecttransforming growth factor beta receptor signaling pathway
GO:0007182
ISO
IEA
Genome Projectcommon-partner SMAD protein phosphorylation
GO:0007183
ISO
IEA
Genome ProjectSMAD protein complex assembly
GO:0007352
ISO
IEA
Genome Projectzygotic specification of dorsal/ventral axis
GO:0007369
IGI
Genome Projectgastrulation
GO:0007389
IGI
Genome Projectpattern specification process
GO:0007492
IGI
Genome Projectendoderm development
GO:0007507
IGI
Genome Projectheart development
GO:0009749
IGI
Genome Projectresponse to glucose
GO:0009791
IGI
Genome Projectpost-embryonic development
GO:0009880
IGI
Genome Projectembryonic pattern specification
GO:0009952
IMP
Genome Projectanterior/posterior pattern specification
GO:0010628
IMP
Genome Projectpositive regulation of gene expression
GO:0010629
IMP
Genome Projectnegative regulation of gene expression
GO:0010718
IMP
Genome Projectpositive regulation of epithelial to mesenchymal transition
GO:0017015
ISO
IEA
Genome Projectregulation of transforming growth factor beta receptor signaling pathway
GO:0030073
IGI
Genome Projectinsulin secretion
GO:0030324
IGI
Genome Projectlung development
GO:0030513
ISO
IEA
Genome Projectpositive regulation of BMP signaling pathway
GO:0031016
IGI
Genome Projectpancreas development
GO:0032924
ISO
IEA
Genome Projectactivin receptor signaling pathway
GO:0035265
IGI
Genome Projectorgan growth
GO:0035556
IDA
Genome Projectintracellular signal transduction
GO:0038092
ISO
IEA
Genome Projectnodal signaling pathway
GO:0045165
IMP
Genome Projectcell fate commitment
GO:0045892
ISO
IEA
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045893
IDA, IMP
ISO
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045944
IDA, IGI
ISO
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0048340
IMP
Genome Projectparaxial mesoderm morphogenesis
GO:0048589
IGI
Genome Projectdevelopmental growth
GO:0048617
IGI
Genome Projectembryonic foregut morphogenesis
GO:0048701
IGI
Genome Projectembryonic cranial skeleton morphogenesis
GO:0051098
IDA
Genome Projectregulation of binding
GO:0060021
IMP
Genome Projectpalate development
GO:0060039
IGI
Genome Projectpericardium development
GO:0060395
IGI
Genome ProjectSMAD protein signal transduction
GO:0070723
ISO
IEA
Genome Projectresponse to cholesterol
GO:1900224
ISO
IEA
Genome Projectpositive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000978
ISO
IEA
Genome ProjectRNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077
ISO
IEA
Genome Projecttranscriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003677
ISO
IEA
Genome ProjectDNA binding
GO:0003682
IDA
Genome Projectchromatin binding
GO:0003690
IDA
Genome Projectdouble-stranded DNA binding
GO:0003700
ISO
IEA
Genome Projecttranscription factor activity, sequence-specific DNA binding
GO:0005160
ISO
IEA
Genome Projecttransforming growth factor beta receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008134
IPI
ISO
IEA
Genome Projecttranscription factor binding
GO:0019902
ISO
IEA
Genome Projectphosphatase binding
GO:0030618
ISO
IEA
Genome Projecttransforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
GO:0031625
ISO
IEA
Genome Projectubiquitin protein ligase binding
GO:0033613
ISO
IEA
Genome Projectactivating transcription factor binding
GO:0034713
ISO
IEA
Genome Projecttype I transforming growth factor beta receptor binding
GO:0042803
IDA
Genome Projectprotein homodimerization activity
GO:0046332
IPI
ISO
IEA
Genome ProjectSMAD binding
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0046982
IDA
Genome Projectprotein heterodimerization activity
GO:0070410
ISO
IEA
Genome Projectco-SMAD binding
GO:0070411
ISO
IEA
Genome ProjectI-SMAD binding
GO:0070412
ISO
IEA
Genome ProjectR-SMAD binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000790
ISO
IEA
Genome Projectnuclear chromatin
GO:0005622
IEA
Genome Projectintracellular
GO:0005634
IDA
ISO
IEA
Genome Projectnucleus
GO:0005667
IDA
ISO
IEA
Genome Projecttranscription factor complex
GO:0005737
IDA
ISO
IEA
Genome Projectcytoplasm
GO:0032444
ISO
IEA
Genome Projectactivin responsive factor complex
GO:0071141
ISO
IEA
Genome ProjectSMAD protein complex
GO:0071144
ISO
IEA
Genome ProjectSMAD2-SMAD3 protein complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001132SMAD domain, Dwarfin-type
IPR003619MAD homology 1, Dwarfin-type
IPR008984SMAD/FHA domain
IPR013019MAD homology, MH1
IPR013790Dwarfin
IPR017855SMAD domain-like

No MapMan annotations defined for this gene.