Gene: ENSMUSG00000024401 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000024401
Transcript Identifier
ENSMUST00000025263
Gene Type
Coding gene
Location
17 : 35200145-35201840 : negative

Family Information

Homologous gene family
HOM03P006776
(13 genes in 2 species)
specific family
Orthologous gene family
ORTHO03P010000
(8 genes in 2 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
tumor necrosis factor

Identifiers

Type Value
UniprotP06804
UniprotQ3U593
MGI104798

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000060
ISO
IEA
Genome Projectprotein import into nucleus, translocation
GO:0000122
IDA
ISO
IEA
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0000165
ISO
IEA
Genome ProjectMAPK cascade
GO:0000185
ISO
IEA
Genome Projectactivation of MAPKKK activity
GO:0000187
ISO
IEA
Genome Projectactivation of MAPK activity
GO:0001819
ISO
IEA
Genome Projectpositive regulation of cytokine production
GO:0001932
IDA
Genome Projectregulation of protein phosphorylation
GO:0001934
ISS, ISO
IEA
Genome Projectpositive regulation of protein phosphorylation
GO:0002439
ISO
IEA
Genome Projectchronic inflammatory response to antigenic stimulus
GO:0002740
ISO
IEA
Genome Projectnegative regulation of cytokine secretion involved in immune response
GO:0002876
IGI
Genome Projectpositive regulation of chronic inflammatory response to antigenic stimulus
GO:0002925
IGI
Genome Projectpositive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0006006
IDA
Genome Projectglucose metabolic process
GO:0006919
IDA
ISO
IEA
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006927
ISO
TAS, IEA
Genome Projecttransformed cell apoptotic process
GO:0006952
IMP
Genome Projectdefense response
GO:0006954
IGI
ISO
TAS, IEA
Genome Projectinflammatory response
GO:0006955
IEA
Genome Projectimmune response
GO:0006959
IMP
Genome Projecthumoral immune response
GO:0007254
IGI
Genome ProjectJNK cascade
GO:0007275
IMP
Genome Projectmulticellular organismal development
GO:0008283
TAS
Genome Projectcell proliferation
GO:0008284
TAS
Genome Projectpositive regulation of cell proliferation
GO:0008625
IGI
ISO
IEA
Genome Projectextrinsic apoptotic signaling pathway via death domain receptors
GO:0008630
IDA
Genome Projectintrinsic apoptotic signaling pathway in response to DNA damage
GO:0009615
ISO
IEA
Genome Projectresponse to virus
GO:0009887
IMP
Genome Projectorgan morphogenesis
GO:0010628
ISO
IEA
Genome Projectpositive regulation of gene expression
GO:0010629
ISO
IEA
Genome Projectnegative regulation of gene expression
GO:0010693
IDA
Genome Projectnegative regulation of alkaline phosphatase activity
GO:0030198
IDA
Genome Projectextracellular matrix organization
GO:0030316
IGI
Genome Projectosteoclast differentiation
GO:0030730
ISO
IEA
Genome Projectsequestering of triglyceride
GO:0031334
ISO
IEA
Genome Projectpositive regulation of protein complex assembly
GO:0031622
IDA
Genome Projectpositive regulation of fever generation
GO:0031663
ISO
IEA
Genome Projectlipopolysaccharide-mediated signaling pathway
GO:0032715
ISO
IEA
Genome Projectnegative regulation of interleukin-6 production
GO:0032722
ISO
IEA
Genome Projectpositive regulation of chemokine production
GO:0032729
IGI
Genome Projectpositive regulation of interferon-gamma production
GO:0032755
IDA
Genome Projectpositive regulation of interleukin-6 production
GO:0032757
ISO
Genome Projectpositive regulation of interleukin-8 production
GO:0032800
ISO
IEA
Genome Projectreceptor biosynthetic process
GO:0033138
ISO
IEA
Genome Projectpositive regulation of peptidyl-serine phosphorylation
GO:0033209
IDA
ISO
IEA
Genome Projecttumor necrosis factor-mediated signaling pathway
GO:0034116
ISO
IEA
Genome Projectpositive regulation of heterotypic cell-cell adhesion
GO:0042127
IDA
Genome Projectregulation of cell proliferation
GO:0042346
IMP
ISO
IEA
Genome Projectpositive regulation of NF-kappaB import into nucleus
GO:0042742
IDA
Genome Projectdefense response to bacterium
GO:0043065
ISS, ISO
IEA
Genome Projectpositive regulation of apoptotic process
GO:0043068
ISO
IEA
Genome Projectpositive regulation of programmed cell death
GO:0043122
ISO
IEA
Genome Projectregulation of I-kappaB kinase/NF-kappaB signaling
GO:0043123
IDA, IGI
ISO
IEA
Genome Projectpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043242
ISS, ISO
IEA
Genome Projectnegative regulation of protein complex disassembly
GO:0043243
ISS, ISO
IEA
Genome Projectpositive regulation of protein complex disassembly
GO:0043280
ISO
IEA
Genome Projectpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043406
ISS, ISO
IEA
Genome Projectpositive regulation of MAP kinase activity
GO:0043491
ISO
IEA
Genome Projectprotein kinase B signaling
GO:0043507
ISS, ISO
IEA
Genome Projectpositive regulation of JUN kinase activity
GO:0044130
IGI
Genome Projectnegative regulation of growth of symbiont in host
GO:0045071
ISO
IEA
Genome Projectnegative regulation of viral genome replication
GO:0045080
ISO
IEA
Genome Projectpositive regulation of chemokine biosynthetic process
GO:0045123
IDA
Genome Projectcellular extravasation
GO:0045416
ISO
IEA
Genome Projectpositive regulation of interleukin-8 biosynthetic process
GO:0045429
ISO
IEA
Genome Projectpositive regulation of nitric oxide biosynthetic process
GO:0045662
IMP
Genome Projectnegative regulation of myoblast differentiation
GO:0045668
IDA
Genome Projectnegative regulation of osteoblast differentiation
GO:0045670
IDA
Genome Projectregulation of osteoclast differentiation
GO:0045672
ISO
IEA
Genome Projectpositive regulation of osteoclast differentiation
GO:0045785
ISO
Genome Projectpositive regulation of cell adhesion
GO:0045860
ISO
IEA
Genome Projectpositive regulation of protein kinase activity
GO:0045892
ISO
IEA
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045893
IDA
ISO
IEA
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045944
IDA, IGI
ISO
IEA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0045994
IDA
Genome Projectpositive regulation of translational initiation by iron
GO:0046325
IDA
Genome Projectnegative regulation of glucose import
GO:0046330
IDA, IGI
Genome Projectpositive regulation of JNK cascade
GO:0048566
IEA
Genome Projectembryonic digestive tract development
GO:0048661
ISO
IEA
Genome Projectpositive regulation of smooth muscle cell proliferation
GO:0050708
IDA
Genome Projectregulation of protein secretion
GO:0050715
ISO
IEA
Genome Projectpositive regulation of cytokine secretion
GO:0050766
ISO
IEA
Genome Projectpositive regulation of phagocytosis
GO:0050796
ISO
IEA
Genome Projectregulation of insulin secretion
GO:0050830
IGI
Genome Projectdefense response to Gram-positive bacterium
GO:0050900
IDA
Genome Projectleukocyte migration
GO:0050901
ISO
IEA
Genome Projectleukocyte tethering or rolling
GO:0050995
ISO
IEA
Genome Projectnegative regulation of lipid catabolic process
GO:0051023
IDA
Genome Projectregulation of immunoglobulin secretion
GO:0051044
ISO
IEA
Genome Projectpositive regulation of membrane protein ectodomain proteolysis
GO:0051091
ISO
IEA
Genome Projectpositive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092
ISO
IEA
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0051222
ISO
IEA
Genome Projectpositive regulation of protein transport
GO:0051384
ISO
IEA
Genome Projectresponse to glucocorticoid
GO:0051533
ISO
IEA
Genome Projectpositive regulation of NFAT protein import into nucleus
GO:0051798
IMP
Genome Projectpositive regulation of hair follicle development
GO:0051897
IDA
Genome Projectpositive regulation of protein kinase B signaling
GO:0060557
ISO
IEA
Genome Projectpositive regulation of vitamin D biosynthetic process
GO:0060559
ISO
IEA
Genome Projectpositive regulation of calcidiol 1-monooxygenase activity
GO:0060664
IDA
Genome Projectepithelial cell proliferation involved in salivary gland morphogenesis
GO:0060693
IDA, IMP
Genome Projectregulation of branching involved in salivary gland morphogenesis
GO:0061048
ISO
IEA
Genome Projectnegative regulation of branching involved in lung morphogenesis
GO:0071222
IDA
Genome Projectcellular response to lipopolysaccharide
GO:0071230
IDA
Genome Projectcellular response to amino acid stimulus
GO:0071316
ISO
IEA
Genome Projectcellular response to nicotine
GO:0071407
ISO
IEA
Genome Projectcellular response to organic cyclic compound
GO:0071803
ISO
IEA
Genome Projectpositive regulation of podosome assembly
GO:0097190
IDA
Genome Projectapoptotic signaling pathway
GO:0097191
IGI
ISO
IEA
Genome Projectextrinsic apoptotic signaling pathway
GO:0097527
IGI
ISS, ISO
IEA
Genome Projectnecroptotic signaling pathway
GO:2000010
ISO
IEA
Genome Projectpositive regulation of protein localization to cell surface
GO:2000343
ISO
IEA
Genome Projectpositive regulation of chemokine (C-X-C motif) ligand 2 production
GO:2000377
IDA
Genome Projectregulation of reactive oxygen species metabolic process
GO:2001240
ISO
IEA
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0002020
IPI
ISO
IEA
Genome Projectprotease binding
GO:0005125
IDA
ISO
IEA
Genome Projectcytokine activity
GO:0005164
IDA, IPI
ISO
TAS, IEA
Genome Projecttumor necrosis factor receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0042802
ISO
IEA
Genome Projectidentical protein binding
GO:0044212
ISO
IEA
Genome Projecttranscription regulatory region DNA binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001891
IDA
Genome Projectphagocytic cup
GO:0005576
IEA
Genome Projectextracellular region
GO:0005615
IDA
ISO
IEA
Genome Projectextracellular space
GO:0005622
IDA
Genome Projectintracellular
GO:0005886
IDA
IEA
Genome Projectplasma membrane
GO:0005887
ISO
TAS, IEA
Genome Projectintegral component of plasma membrane
GO:0009897
IDA
Genome Projectexternal side of plasma membrane
GO:0009986
ISO
IEA
Genome Projectcell surface
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0030141
TAS
Genome Projectsecretory granule
GO:0045121
IDA
ISO
IEA
Genome Projectmembrane raft
GO:0055037
IDA
Genome Projectrecycling endosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR002959Tumour necrosis factor alpha
IPR006052Tumour necrosis factor domain
IPR006053Tumour necrosis factor
IPR008983Tumour necrosis factor-like domain
IPR021184Tumour necrosis factor, conserved site

No MapMan annotations defined for this gene.