Gene: ENSMUSG00000024164 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000024164
Transcript Identifier
ENSMUST00000024988
Gene Type
Coding gene
Location
17 : 57204013-57228035 : negative

Family Information

Homologous gene family
HOM03P002669
(35 genes in 6 species)
specific family
Orthologous gene family
ORTHO03P006383
(13 genes in 2 species)
specific family

Descriptions

gene_descr
complement component 3

Identifiers

Type Value
UniprotP01027
MGI88227

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001798
IMP
Genome Projectpositive regulation of type IIa hypersensitivity
GO:0001934
ISS, ISO
IEA
Genome Projectpositive regulation of protein phosphorylation
GO:0001970
IMP
Genome Projectpositive regulation of activation of membrane attack complex
GO:0002376
IEA
Genome Projectimmune system process
GO:0002507
IEA
Genome Projecttolerance induction
GO:0006629
IEA
Genome Projectlipid metabolic process
GO:0006631
IEA
Genome Projectfatty acid metabolic process
GO:0006954
IEA
Genome Projectinflammatory response
GO:0006956
IDA
ISO
IEA
Genome Projectcomplement activation
GO:0006957
IEA
Genome Projectcomplement activation, alternative pathway
GO:0006958
IEA
Genome Projectcomplement activation, classical pathway
GO:0007596
IEA
Genome Projectblood coagulation
GO:0010575
ISO
IEA
Genome Projectpositive regulation of vascular endothelial growth factor production
GO:0010828
ISS, ISO
IEA
Genome Projectpositive regulation of glucose transport
GO:0010866
ISS, ISO
IEA
Genome Projectregulation of triglyceride biosynthetic process
GO:0010884
ISS, ISO
IEA
Genome Projectpositive regulation of lipid storage
GO:0010951
IEA
Genome Projectnegative regulation of endopeptidase activity
GO:0032026
IEA
Genome Projectresponse to magnesium ion
GO:0032355
IEA
Genome Projectresponse to estradiol
GO:0032570
IEA
Genome Projectresponse to progesterone
GO:0043627
IEA
Genome Projectresponse to estrogen
GO:0045087
IEA
Genome Projectinnate immune response
GO:0045745
ISS, ISO
IEA
Genome Projectpositive regulation of G-protein coupled receptor protein signaling pathway
GO:0045766
IMP
Genome Projectpositive regulation of angiogenesis
GO:0048639
IEA
Genome Projectpositive regulation of developmental growth
GO:0050766
IMP
Genome Projectpositive regulation of phagocytosis
GO:0051384
IEA
Genome Projectresponse to glucocorticoid
GO:0070374
IEA
Genome Projectpositive regulation of ERK1 and ERK2 cascade
GO:2000427
ISO
IEA
Genome Projectpositive regulation of apoptotic cell clearance

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004866
IEA
Genome Projectendopeptidase inhibitor activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0008289
IEA
Genome Projectlipid binding
GO:0031715
ISS, ISO
IEA
Genome ProjectC5L2 anaphylatoxin chemotactic receptor binding
GO:0048037
IEA
Genome Projectcofactor binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
IEA
Genome Projectextracellular region
GO:0005615
ISO
IEA
Genome Projectextracellular space
GO:0070062
ISO
IEA
Genome Projectextracellular exosome
GO:0072562
ISO
IEA
Genome Projectblood microparticle

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000020Anaphylatoxin/fibulin
IPR001134Netrin domain
IPR001599Alpha-2-macroglobulin
IPR001840Anaphylatoxin, complement system domain
IPR002890Alpha-2-macroglobulin, N-terminal
IPR008930Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
IPR008993Tissue inhibitor of metalloproteinases-like, OB-fold
IPR009048Alpha-macroglobulin, receptor-binding
IPR011625Alpha-2-macroglobulin, N-terminal 2
IPR011626Alpha-macroglobulin complement component
IPR018081Anaphylatoxin, complement system
IPR018933Netrin module, non-TIMP type
IPR019565Alpha-2-macroglobulin, thiol-ester bond-forming
IPR019742Alpha-2-macroglobulin, conserved site

No MapMan annotations defined for this gene.