Gene: ENSMUSG00000023826 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000023826
Transcript Identifier
ENSMUST00000191124
Gene Type
Coding gene
Location
17 : 10840483-12061653 : positive

Family Information

Homologous gene family
HOM03P000189
(175 genes in 36 species)
specific family
Orthologous gene family
ORTHO03P029189
(4 genes in 4 species)
specific family

Descriptions

gene_descr
Parkinson disease (autosomal recessive, juvenile) 2, parkin

Identifiers

Type Value
UniprotQ9WVS6
MGI1355296

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000209
ISS, ISO
IEA
Genome Projectprotein polyubiquitination
GO:0000266
ISS
Genome Projectmitochondrial fission
GO:0000422
ISS, ISO
Genome Projectmitophagy
GO:0001933
ISO
IEA
Genome Projectnegative regulation of protein phosphorylation
GO:0001963
IMP
Genome Projectsynaptic transmission, dopaminergic
GO:0001964
IMP
Genome Projectstartle response
GO:0006351
IEA
Genome Projecttranscription, DNA-templated
GO:0006355
IEA
Genome Projectregulation of transcription, DNA-templated
GO:0006513
ISS, ISO
IEA
Genome Projectprotein monoubiquitination
GO:0006914
IEA
Genome Projectautophagy
GO:0006979
ISS
Genome Projectresponse to oxidative stress
GO:0007005
ISS
Genome Projectmitochondrion organization
GO:0007612
IMP
Genome Projectlearning
GO:0007626
IMP
Genome Projectlocomotory behavior
GO:0008344
IMP
Genome Projectadult locomotory behavior
GO:0010498
ISO
Genome Projectproteasomal protein catabolic process
GO:0010506
ISS, ISO
IEA
Genome Projectregulation of autophagy
GO:0010628
ISO
Genome Projectpositive regulation of gene expression
GO:0010629
ISO
Genome Projectnegative regulation of gene expression
GO:0010636
ISO
IEA
Genome Projectpositive regulation of mitochondrial fusion
GO:0010637
ISS
Genome Projectnegative regulation of mitochondrial fusion
GO:0010821
ISS, ISO
IEA
Genome Projectregulation of mitochondrion organization
GO:0016567
ISS, ISO
IEA
Genome Projectprotein ubiquitination
GO:0019538
IMP
Genome Projectprotein metabolic process
GO:0031396
ISO
IEA
Genome Projectregulation of protein ubiquitination
GO:0032232
ISO
IEA
Genome Projectnegative regulation of actin filament bundle assembly
GO:0032436
IMP
Genome Projectpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0033132
ISO
IEA
Genome Projectnegative regulation of glucokinase activity
GO:0034976
IMP
ISO
IEA
Genome Projectresponse to endoplasmic reticulum stress
GO:0035249
IMP
Genome Projectsynaptic transmission, glutamatergic
GO:0042053
ISO
Genome Projectregulation of dopamine metabolic process
GO:0042415
IMP
Genome Projectnorepinephrine metabolic process
GO:0042417
IMP
Genome Projectdopamine metabolic process
GO:0042787
ISS, ISO
Genome Projectprotein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043123
ISO
IEA
Genome Projectpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161
ISO
IEA
Genome Projectproteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043388
ISO
IEA
Genome Projectpositive regulation of DNA binding
GO:0043524
IMP
ISO
IEA
Genome Projectnegative regulation of neuron apoptotic process
GO:0044257
IMP
ISO
IEA
Genome Projectcellular protein catabolic process
GO:0044828
ISO
IEA
Genome Projectnegative regulation by host of viral genome replication
GO:0045944
ISO
IEA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046329
ISS
Genome Projectnegative regulation of JNK cascade
GO:0046676
ISO
IEA
Genome Projectnegative regulation of insulin secretion
GO:0046928
IMP
Genome Projectregulation of neurotransmitter secretion
GO:0050804
IMP
Genome Projectmodulation of synaptic transmission
GO:0050821
ISO
IEA
Genome Projectprotein stabilization
GO:0051582
ISO
Genome Projectpositive regulation of neurotransmitter uptake
GO:0051583
IMP
Genome Projectdopamine uptake involved in synaptic transmission
GO:0051865
ISS, ISO
IEA
Genome Projectprotein autoubiquitination
GO:0051881
IGI
Genome Projectregulation of mitochondrial membrane potential
GO:0055069
ISS
Genome Projectzinc ion homeostasis
GO:0060548
ISO
IEA
Genome Projectnegative regulation of cell death
GO:0070050
ISS
Genome Projectneuron cellular homeostasis
GO:0070534
ISS, ISO
IEA
Genome Projectprotein K63-linked ubiquitination
GO:0070585
IMP
Genome Projectprotein localization to mitochondrion
GO:0070842
ISO
IEA
Genome Projectaggresome assembly
GO:0070936
ISS, ISO
IEA
Genome Projectprotein K48-linked ubiquitination
GO:0070979
ISS, ISO
IEA
Genome Projectprotein K11-linked ubiquitination
GO:0085020
ISS, ISO
Genome Projectprotein K6-linked ubiquitination
GO:0090141
ISS
Genome Projectpositive regulation of mitochondrial fission
GO:0090201
ISO
IEA
Genome Projectnegative regulation of release of cytochrome c from mitochondria
GO:0097237
IDA
ISO
IEA
Genome Projectcellular response to toxic substance
GO:0098779
ISO
IEA
Genome Projectmitophagy in response to mitochondrial depolarization
GO:1900407
ISS, ISO
Genome Projectregulation of cellular response to oxidative stress
GO:1901215
IMP
ISO
IEA
Genome Projectnegative regulation of neuron death
GO:1901800
ISO
IEA
Genome Projectpositive regulation of proteasomal protein catabolic process
GO:1902236
IMP
ISO
IEA
Genome Projectnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1902283
ISO
Genome Projectnegative regulation of primary amine oxidase activity
GO:1902530
IMP
ISO
IEA
Genome Projectpositive regulation of protein linear polyubiquitination
GO:1903265
ISO
IEA
Genome Projectpositive regulation of tumor necrosis factor-mediated signaling pathway
GO:1903377
ISO
IEA
Genome Projectnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903378
IMP
Genome Projectpositive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903382
IMP, IGI
Genome Projectnegative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903861
IGI
Genome Projectpositive regulation of dendrite extension
GO:1904049
ISO
Genome Projectnegative regulation of spontaneous neurotransmitter secretion
GO:2000377
ISO
IEA
Genome Projectregulation of reactive oxygen species metabolic process
GO:2000378
ISO
IEA
Genome Projectnegative regulation of reactive oxygen species metabolic process

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001664
ISO
IEA
Genome ProjectG-protein coupled receptor binding
GO:0003779
ISO
IEA
Genome Projectactin binding
GO:0004842
ISO
IEA
Genome Projectubiquitin-protein transferase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0008270
IEA
Genome Projectzinc ion binding
GO:0015631
ISO
IEA
Genome Projecttubulin binding
GO:0016874
IEA
Genome Projectligase activity
GO:0019899
ISO
Genome Projectenzyme binding
GO:0019900
ISO
IEA
Genome Projectkinase binding
GO:0019901
ISO
IEA
Genome Projectprotein kinase binding
GO:0030165
ISO
IEA
Genome ProjectPDZ domain binding
GO:0030544
ISO
IEA
Genome ProjectHsp70 protein binding
GO:0031072
ISO
IEA
Genome Projectheat shock protein binding
GO:0031624
ISO
IEA
Genome Projectubiquitin conjugating enzyme binding
GO:0031625
ISO
IEA
Genome Projectubiquitin protein ligase binding
GO:0042802
ISO
IEA
Genome Projectidentical protein binding
GO:0042826
ISO
IEA
Genome Projecthistone deacetylase binding
GO:0043130
ISS, ISO
IEA
Genome Projectubiquitin binding
GO:0043274
ISO
Genome Projectphospholipase binding
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0051087
ISO
IEA
Genome Projectchaperone binding
GO:0061630
IDA
ISO
IEA
Genome Projectubiquitin protein ligase activity
GO:0097602
ISO
IEA
Genome Projectcullin family protein binding
GO:1990381
ISO
IEA
Genome Projectubiquitin-specific protease binding
GO:1990444
ISO
IEA
Genome ProjectF-box domain binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000151
ISO
IEA
Genome Projectubiquitin ligase complex
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005737
IDA
ISS, ISO
IEA
Genome Projectcytoplasm
GO:0005739
IDA
ISS, ISO
IEA
Genome Projectmitochondrion
GO:0005783
ISO
IEA
Genome Projectendoplasmic reticulum
GO:0005794
ISO
IEA
Genome ProjectGolgi apparatus
GO:0005829
ISS, ISO
IEA
Genome Projectcytosol
GO:0005886
IEA
Genome Projectplasma membrane
GO:0014069
IEA
Genome Projectpostsynaptic density
GO:0016020
IEA
Genome Projectmembrane
GO:0016235
ISO
IEA
Genome Projectaggresome
GO:0030054
IEA
Genome Projectcell junction
GO:0030425
IEA
Genome Projectdendrite
GO:0042995
IEA
Genome Projectcell projection
GO:0043005
IDA
Genome Projectneuron projection
GO:0043234
IDA
Genome Projectprotein complex
GO:0045202
IEA
Genome Projectsynapse
GO:0045211
IEA
Genome Projectpostsynaptic membrane
GO:0048471
ISO
IEA
Genome Projectperinuclear region of cytoplasm
GO:0071797
ISO
IEA
Genome ProjectLUBAC complex
GO:1990452
ISO
IEA
Genome ProjectParkin-FBXW7-Cul1 ubiquitin ligase complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000626Ubiquitin domain
IPR002867IBR domain
IPR003977E3 ubiquitin-protein ligase parkin
IPR029071Ubiquitin-related domain
IPR031127E3 ubiquitin ligase RBR family

No MapMan annotations defined for this gene.