Gene: ENSMUSG00000023067 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000023067
Transcript Identifier
ENSMUST00000122348
Gene Type
Coding gene
Location
17 : 29098408-29099393 : positive

Family Information

Homologous gene family
HOM03P029825
(3 genes in 2 species)
specific family

Descriptions

gene_descr
cyclin-dependent kinase inhibitor 1A (P21)

Identifiers

Type Value
UniprotP39689
UniprotQ564P6
MGI104556

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000079
IMP
Genome Projectregulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082
ISO
IEA
Genome ProjectG1/S transition of mitotic cell cycle
GO:0000086
ISO
IEA
Genome ProjectG2/M transition of mitotic cell cycle
GO:0006468
ISO
IEA
Genome Projectprotein phosphorylation
GO:0006974
IMP
ISO
IEA
Genome Projectcellular response to DNA damage stimulus
GO:0006977
ISO
IEA
Genome ProjectDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007049
IEA
Genome Projectcell cycle
GO:0007050
IDA, IMP
ISO
IEA
Genome Projectcell cycle arrest
GO:0007265
IEA
Genome ProjectRas protein signal transduction
GO:0007346
IMP
IEA
Genome Projectregulation of mitotic cell cycle
GO:0008285
IMP
ISO
IEA
Genome Projectnegative regulation of cell proliferation
GO:0009411
IMP
Genome Projectresponse to UV
GO:0009636
IEA
Genome Projectresponse to toxic substance
GO:0010033
IEA
Genome Projectresponse to organic substance
GO:0010165
IEA
Genome Projectresponse to X-ray
GO:0010243
IEA
Genome Projectresponse to organonitrogen compound
GO:0010629
IMP
Genome Projectnegative regulation of gene expression
GO:0014070
IEA
Genome Projectresponse to organic cyclic compound
GO:0030308
ISO
IEA
Genome Projectnegative regulation of cell growth
GO:0030890
IGI
Genome Projectpositive regulation of B cell proliferation
GO:0031100
IEA
Genome Projectorgan regeneration
GO:0031668
ISO
IEA
Genome Projectcellular response to extracellular stimulus
GO:0032147
ISO
Genome Projectactivation of protein kinase activity
GO:0033158
IMP
Genome Projectregulation of protein import into nucleus, translocation
GO:0034605
IEA
Genome Projectcellular response to heat
GO:0042326
ISO
IEA
Genome Projectnegative regulation of phosphorylation
GO:0042493
IEA
Genome Projectresponse to drug
GO:0042771
IMP
Genome Projectintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043066
IEA
Genome Projectnegative regulation of apoptotic process
GO:0043068
IMP
Genome Projectpositive regulation of programmed cell death
GO:0045736
IDA
Genome Projectnegative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045860
IEA
Genome Projectpositive regulation of protein kinase activity
GO:0046685
IEA
Genome Projectresponse to arsenic-containing substance
GO:0048146
ISO
IEA
Genome Projectpositive regulation of fibroblast proliferation
GO:0051384
IEA
Genome Projectresponse to glucocorticoid
GO:0051412
IEA
Genome Projectresponse to corticosterone
GO:0051726
IDA
Genome Projectregulation of cell cycle
GO:0055093
IEA
Genome Projectresponse to hyperoxia
GO:0060574
IEA
Genome Projectintestinal epithelial cell maturation
GO:0071479
IMP
ISO
IEA
Genome Projectcellular response to ionizing radiation
GO:0071493
IDA
Genome Projectcellular response to UV-B
GO:0071850
IDA
Genome Projectmitotic cell cycle arrest
GO:0072331
IEA
Genome Projectsignal transduction by p53 class mediator
GO:0090398
ISO
IEA
Genome Projectcellular senescence
GO:1904031
ISO
IEA
Genome Projectpositive regulation of cyclin-dependent protein kinase activity
GO:2000134
ISO
IEA
Genome Projectnegative regulation of G1/S transition of mitotic cell cycle
GO:2000278
IMP
Genome Projectregulation of DNA biosynthetic process
GO:2000379
IMP
ISO
IEA
Genome Projectpositive regulation of reactive oxygen species metabolic process
GO:0016310
IEA
Genome Projectphosphorylation
GO:0090399
IMP
Genome Projectreplicative senescence

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004860
IEA
Genome Projectprotein kinase inhibitor activity
GO:0004861
IDA
IEA
Genome Projectcyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0019912
ISO
IEA
Genome Projectcyclin-dependent protein kinase activating kinase activity
GO:0030332
IDA
Genome Projectcyclin binding
GO:0031625
ISO
IEA
Genome Projectubiquitin protein ligase binding
GO:0032403
IEA
Genome Projectprotein complex binding
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0016301
IEA
Genome Projectkinase activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000307
IPI
ISO
IEA
Genome Projectcyclin-dependent protein kinase holoenzyme complex
GO:0005634
IDA
ISO
IEA
Genome Projectnucleus
GO:0005654
ISO
IEA
Genome Projectnucleoplasm
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005829
IDA
Genome Projectcytosol
GO:0043231
ISO
IEA
Genome Projectintracellular membrane-bounded organelle
GO:0048471
IEA
Genome Projectperinuclear region of cytoplasm
GO:0070557
ISS, ISO
IEA
Genome ProjectPCNA-p21 complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR003175Cyclin-dependent kinase inhibitor
IPR029841Cyclin-dependent kinase inhibitor 1, vertebrate

No MapMan annotations defined for this gene.