Gene: ENSMUSG00000022892 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000022892
Transcript Identifier
ENSMUST00000005406
Gene Type
Coding gene
Location
16 : 84955331-85173558 : negative

Family Information

Homologous gene family
HOM03P008668
(9 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P063640
(2 genes in 2 species)
specific family

Descriptions

gene_descr
amyloid beta (A4) precursor protein

Identifiers

Type Value
UniprotP12023
UniprotQ6GR78
MGI88059

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001967
IGI
Genome Projectsuckling behavior
GO:0006378
IDA
Genome ProjectmRNA polyadenylation
GO:0006417
IDA
Genome Projectregulation of translation
GO:0006468
IMP
Genome Projectprotein phosphorylation
GO:0006878
IMP, IGI
Genome Projectcellular copper ion homeostasis
GO:0006897
IMP
IEA
Genome Projectendocytosis
GO:0006915
IEA
Genome Projectapoptotic process
GO:0006979
IGI
Genome Projectresponse to oxidative stress
GO:0007155
IEA
Genome Projectcell adhesion
GO:0007176
IGI
Genome Projectregulation of epidermal growth factor-activated receptor activity
GO:0007219
IEA
Genome ProjectNotch signaling pathway
GO:0007399
IEA
Genome Projectnervous system development
GO:0007409
IMP
Genome Projectaxonogenesis
GO:0007617
IGI
Genome Projectmating behavior
GO:0007626
IGI
Genome Projectlocomotory behavior
GO:0008088
IMP, IGI
Genome Projectaxon cargo transport
GO:0008203
IMP, IGI
Genome Projectcholesterol metabolic process
GO:0008344
IMP
Genome Projectadult locomotory behavior
GO:0008542
IMP
Genome Projectvisual learning
GO:0010466
IEA
Genome Projectnegative regulation of peptidase activity
GO:0010468
IDA
Genome Projectregulation of gene expression
GO:0010951
ISO
Genome Projectnegative regulation of endopeptidase activity
GO:0010952
IEA
Genome Projectpositive regulation of peptidase activity
GO:0010971
IMP
Genome Projectpositive regulation of G2/M transition of mitotic cell cycle
GO:0016199
IMP
Genome Projectaxon midline choice point recognition
GO:0016322
IMP
Genome Projectneuron remodeling
GO:0016358
IMP, IGI
Genome Projectdendrite development
GO:0030198
IGI
Genome Projectextracellular matrix organization
GO:0030900
IMP
Genome Projectforebrain development
GO:0031175
IDA
Genome Projectneuron projection development
GO:0035235
IMP
Genome Projectionotropic glutamate receptor signaling pathway
GO:0040014
IMP
Genome Projectregulation of multicellular organism growth
GO:0043393
IMP, IGI
Genome Projectregulation of protein binding
GO:0045665
IDA, IGI
Genome Projectnegative regulation of neuron differentiation
GO:0045931
IMP
Genome Projectpositive regulation of mitotic cell cycle
GO:0045944
IDA, IGI
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0048669
IGI
Genome Projectcollateral sprouting in absence of injury
GO:0050803
IMP
Genome Projectregulation of synapse structure or activity
GO:0050885
IGI
Genome Projectneuromuscular process controlling balance
GO:0051124
IGI
Genome Projectsynaptic growth at neuromuscular junction
GO:0051260
ISO
Genome Projectprotein homooligomerization
GO:0051402
IGI
ISO
IEA
Genome Projectneuron apoptotic process
GO:0051563
IGI
Genome Projectsmooth endoplasmic reticulum calcium ion homeostasis

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0003677
IDA
Genome ProjectDNA binding
GO:0004867
ISO
IEA
Genome Projectserine-type endopeptidase inhibitor activity
GO:0005102
ISO
IEA
Genome Projectreceptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008201
IEA
Genome Projectheparin binding
GO:0016504
IEA
Genome Projectpeptidase activator activity
GO:0019899
ISO
IEA
Genome Projectenzyme binding
GO:0030414
IEA
Genome Projectpeptidase inhibitor activity
GO:0033130
ISO
IEA
Genome Projectacetylcholine receptor binding
GO:0042802
ISO
IEA
Genome Projectidentical protein binding
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0046914
IEA
Genome Projecttransition metal ion binding
GO:0051425
ISO
IEA
Genome ProjectPTB domain binding
GO:0070851
IEA
Genome Projectgrowth factor receptor binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005615
ISO
IEA
Genome Projectextracellular space
GO:0005641
ISO
IEA
Genome Projectnuclear envelope lumen
GO:0005737
IDA
ISO
Genome Projectcytoplasm
GO:0005768
ISO
IEA
Genome Projectendosome
GO:0005790
IGI
Genome Projectsmooth endoplasmic reticulum
GO:0005794
IDA
ISO
Genome ProjectGolgi apparatus
GO:0005886
IDA
ISO
IEA
Genome Projectplasma membrane
GO:0005905
IEA
Genome Projectcoated pit
GO:0005911
IDA
Genome Projectcell-cell junction
GO:0009986
ISO
IEA
Genome Projectcell surface
GO:0016020
IDA
TAS, IEA
Genome Projectmembrane
GO:0016021
IDA
IEA
Genome Projectintegral component of membrane
GO:0030134
IDA
Genome ProjectER to Golgi transport vesicle
GO:0030424
IDA
Genome Projectaxon
GO:0031410
IDA
Genome Projectcytoplasmic vesicle
GO:0031594
IDA
Genome Projectneuromuscular junction
GO:0035253
IDA
Genome Projectciliary rootlet
GO:0043005
IDA
IEA
Genome Projectneuron projection
GO:0043195
IEA
Genome Projectterminal bouton
GO:0043197
IEA
Genome Projectdendritic spine
GO:0043198
IEA
Genome Projectdendritic shaft
GO:0043231
ISO
IEA
Genome Projectintracellular membrane-bounded organelle
GO:0043235
ISO
IEA
Genome Projectreceptor complex
GO:0045121
ISO
IEA
Genome Projectmembrane raft
GO:0045177
IDA
Genome Projectapical part of cell
GO:0045202
IEA
Genome Projectsynapse
GO:0048471
IDA
ISO
IEA
Genome Projectperinuclear region of cytoplasm
GO:0051233
IDA
Genome Projectspindle midzone
GO:0070062
ISO
IEA
Genome Projectextracellular exosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR002223Pancreatic trypsin inhibitor Kunitz domain
IPR008154Amyloidogenic glycoprotein, extracellular
IPR008155Amyloidogenic glycoprotein
IPR011178Amyloidogenic glycoprotein, copper-binding
IPR013803Amyloidogenic glycoprotein, amyloid-beta peptide
IPR015849Amyloidogenic glycoprotein, heparin-binding
IPR019543Beta-amyloid precursor protein C-terminal
IPR019744Amyloidogenic glycoprotein, extracellular domain conserved site
IPR019745Amyloidogenic glycoprotein, intracellular domain, conserved site
IPR020901Proteinase inhibitor I2, Kunitz, conserved site
IPR024329Amyloidogenic glycoprotein, E2 domain
IPR028866Amyloid beta A4 protein

No MapMan annotations defined for this gene.