Gene: ENSMUSG00000022607 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000022607
Transcript Identifier
ENSMUST00000110036
Gene Type
Coding gene
Location
15 : 73206048-73343327 : negative

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P015372
(6 genes in 4 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
PTK2 protein tyrosine kinase 2

Identifiers

Type Value
UniprotP34152
MGI95481

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000226
IDA
Genome Projectmicrotubule cytoskeleton organization
GO:0001525
IMP
IEA
Genome Projectangiogenesis
GO:0001568
IMP
Genome Projectblood vessel development
GO:0001570
IMP
Genome Projectvasculogenesis
GO:0001764
IDA, IMP
Genome Projectneuron migration
GO:0001932
ISO
Genome Projectregulation of protein phosphorylation
GO:0001934
ISS, ISO
IEA
Genome Projectpositive regulation of protein phosphorylation
GO:0006468
IEA
Genome Projectprotein phosphorylation
GO:0007155
IBA
Genome Projectcell adhesion
GO:0007172
IEA
Genome Projectsignal complex assembly
GO:0007173
IBA
Genome Projectepidermal growth factor receptor signaling pathway
GO:0007179
ISO
IEA
Genome Projecttransforming growth factor beta receptor signaling pathway
GO:0007229
ISS, ISO
TAS, IEA
Genome Projectintegrin-mediated signaling pathway
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0008284
IMP
Genome Projectpositive regulation of cell proliferation
GO:0008360
ISS, ISO
IEA
Genome Projectregulation of cell shape
GO:0010632
ISO
Genome Projectregulation of epithelial cell migration
GO:0014068
ISS, ISO
IEA
Genome Projectpositive regulation of phosphatidylinositol 3-kinase signaling
GO:0016310
IEA
Genome Projectphosphorylation
GO:0018108
IDA
ISS, ISO
Genome Projectpeptidyl-tyrosine phosphorylation
GO:0021955
IMP
Genome Projectcentral nervous system neuron axonogenesis
GO:0022408
ISO
IEA
Genome Projectnegative regulation of cell-cell adhesion
GO:0030155
IBA
Genome Projectregulation of cell adhesion
GO:0030198
IMP
Genome Projectextracellular matrix organization
GO:0030335
ISS, ISO
IEA
Genome Projectpositive regulation of cell migration
GO:0033628
ISS, ISO
IEA
Genome Projectregulation of cell adhesion mediated by integrin
GO:0038083
IBA
Genome Projectpeptidyl-tyrosine autophosphorylation
GO:0040023
IDA
Genome Projectestablishment of nucleus localization
GO:0042127
ISS, ISO
IEA
Genome Projectregulation of cell proliferation
GO:0043066
ISS, ISO, IBA
IEA
Genome Projectnegative regulation of apoptotic process
GO:0043542
IMP
Genome Projectendothelial cell migration
GO:0045087
IBA
Genome Projectinnate immune response
GO:0045667
ISS, ISO
IEA
Genome Projectregulation of osteoblast differentiation
GO:0045860
ISS, ISO
IEA
Genome Projectpositive regulation of protein kinase activity
GO:0046621
IGI
Genome Projectnegative regulation of organ growth
GO:0046777
IDA, IMP
ISO
IEA
Genome Projectprotein autophosphorylation
GO:0048013
ISS, ISO
IEA
Genome Projectephrin receptor signaling pathway
GO:0050771
IMP
Genome Projectnegative regulation of axonogenesis
GO:0051893
ISO
Genome Projectregulation of focal adhesion assembly
GO:0051897
ISS, ISO
IEA
Genome Projectpositive regulation of protein kinase B signaling
GO:0051964
IMP
Genome Projectnegative regulation of synapse assembly
GO:0060396
ISO
IEA
Genome Projectgrowth hormone receptor signaling pathway
GO:0071560
IDA
Genome Projectcellular response to transforming growth factor beta stimulus
GO:1900024
ISO
Genome Projectregulation of substrate adhesion-dependent cell spreading
GO:2000060
IMP
Genome Projectpositive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000811
ISO
IEA
Genome Projectnegative regulation of anoikis

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0003779
ISO
IEA
Genome Projectactin binding
GO:0004672
IEA
Genome Projectprotein kinase activity
GO:0004713
EXP, IDA
ISS, ISO
IEA
Genome Projectprotein tyrosine kinase activity
GO:0004715
ISS, ISO, IBA
IEA
Genome Projectnon-membrane spanning protein tyrosine kinase activity
GO:0004871
IEA
Genome Projectsignal transducer activity
GO:0005102
IBA
Genome Projectreceptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0008432
ISO
IEA
Genome ProjectJUN kinase binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0019901
ISO
IEA
Genome Projectprotein kinase binding
GO:0042169
ISO
IEA
Genome ProjectSH2 domain binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001725
ISO
IEA
Genome Projectstress fiber
GO:0005634
IDA
ISO
IEA
Genome Projectnucleus
GO:0005737
ISO
IEA
Genome Projectcytoplasm
GO:0005815
IEA
Genome Projectmicrotubule organizing center
GO:0005829
ISO
TAS, IEA
Genome Projectcytosol
GO:0005856
IEA
Genome Projectcytoskeleton
GO:0005886
ISO
IEA
Genome Projectplasma membrane
GO:0005925
IDA
ISO
IEA
Genome Projectfocal adhesion
GO:0016020
IEA
Genome Projectmembrane
GO:0016324
IDA
Genome Projectapical plasma membrane
GO:0030027
IDA
Genome Projectlamellipodium
GO:0030054
IEA
Genome Projectcell junction
GO:0031234
IBA
Genome Projectextrinsic component of cytoplasmic side of plasma membrane
GO:0048471
IEA
Genome Projectperinuclear region of cytoplasm

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000299FERM domain
IPR000719Protein kinase domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR005189Focal adhesion kinase, targeting (FAT) domain
IPR008266Tyrosine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR017441Protein kinase, ATP binding site
IPR019748FERM central domain
IPR019749Band 4.1 domain
IPR020635Tyrosine-protein kinase, catalytic domain
IPR029071Ubiquitin-related domain

No MapMan annotations defined for this gene.