Gene: ENSMUSG00000022105 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000022105
Transcript Identifier
ENSMUST00000022701
Gene Type
Coding gene
Location
14 : 73197211-73325641 : negative

Family Information

Homologous gene family
HOM03P002379
(38 genes in 27 species)
specific family
Orthologous gene family
ORTHO03P004461
(19 genes in 17 species)
specific family

Descriptions

gene_descr
retinoblastoma 1

Identifiers

Type Value
UniprotP13405
MGI97874

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000082
IMP
Genome ProjectG1/S transition of mitotic cell cycle
GO:0000122
IDA, IGI
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0006351
IEA
Genome Projecttranscription, DNA-templated
GO:0006355
IEA
Genome Projectregulation of transcription, DNA-templated
GO:0006357
IEA
Genome Projectregulation of transcription from RNA polymerase II promoter
GO:0006469
ISS, ISO
IEA
Genome Projectnegative regulation of protein kinase activity
GO:0007049
IEA
Genome Projectcell cycle
GO:0007050
IMP
Genome Projectcell cycle arrest
GO:0007265
IEA
Genome ProjectRas protein signal transduction
GO:0007346
ISO
IEA
Genome Projectregulation of mitotic cell cycle
GO:0008285
IMP, IGI
Genome Projectnegative regulation of cell proliferation
GO:0016568
IEA
Genome Projectchromatin modification
GO:0030182
IMP
Genome Projectneuron differentiation
GO:0031134
ISO
IEA
Genome Projectsister chromatid biorientation
GO:0031175
IMP
Genome Projectneuron projection development
GO:0034088
ISO
IEA
Genome Projectmaintenance of mitotic sister chromatid cohesion
GO:0034349
IMP
Genome Projectglial cell apoptotic process
GO:0035914
IMP
Genome Projectskeletal muscle cell differentiation
GO:0042551
IMP
Genome Projectneuron maturation
GO:0043353
IGI
Genome Projectenucleate erythrocyte differentiation
GO:0043550
ISS, ISO
IEA
Genome Projectregulation of lipid kinase activity
GO:0045445
ISS, ISO
IEA
Genome Projectmyoblast differentiation
GO:0045651
IGI
Genome Projectpositive regulation of macrophage differentiation
GO:0045786
IMP
Genome Projectnegative regulation of cell cycle
GO:0045842
ISO
IEA
Genome Projectpositive regulation of mitotic metaphase/anaphase transition
GO:0045879
IMP
Genome Projectnegative regulation of smoothened signaling pathway
GO:0045892
IDA
ISO
IEA
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045930
IGI
Genome Projectnegative regulation of mitotic cell cycle
GO:0045944
IDA, IMP, IGI
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0048565
IMP
Genome Projectdigestive tract development
GO:0048667
IMP
Genome Projectcell morphogenesis involved in neuron differentiation
GO:0050680
IMP
Genome Projectnegative regulation of epithelial cell proliferation
GO:0051146
IGI
Genome Projectstriated muscle cell differentiation
GO:0051301
IMP
Genome Projectcell division
GO:0051402
IMP
Genome Projectneuron apoptotic process
GO:0051726
IMP
IEA
Genome Projectregulation of cell cycle
GO:0071459
ISO
IEA
Genome Projectprotein localization to chromosome, centromeric region
GO:0071466
IMP
Genome Projectcellular response to xenobiotic stimulus
GO:0071922
ISO
IEA
Genome Projectregulation of cohesin localization to chromatin
GO:0071930
IGI
Genome Projectnegative regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0097284
IMP
Genome Projecthepatocyte apoptotic process
GO:2000134
IMP
Genome Projectnegative regulation of G1/S transition of mitotic cell cycle

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001047
ISO
IEA
Genome Projectcore promoter binding
GO:0001102
IPI
Genome ProjectRNA polymerase II activating transcription factor binding
GO:0003677
IEA
Genome ProjectDNA binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008134
IPI
ISS, ISO
IEA
Genome Projecttranscription factor binding
GO:0019899
IPI
Genome Projectenzyme binding
GO:0019900
ISS, ISO
IEA
Genome Projectkinase binding
GO:0031625
ISO
IEA
Genome Projectubiquitin protein ligase binding
GO:0042802
ISO
IEA
Genome Projectidentical protein binding
GO:0051219
ISO
IEA
Genome Projectphosphoprotein binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
ISS, ISO
IEA
Genome Projectnucleus
GO:0005667
IDA
Genome Projecttranscription factor complex
GO:0005819
IDA
Genome Projectspindle
GO:0016605
ISS, ISO
IEA
Genome ProjectPML body
GO:0035189
IDA
Genome ProjectRb-E2F complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR002719Retinoblastoma-associated protein, B-box
IPR002720Retinoblastoma-associated protein, A-box
IPR013763Cyclin-like
IPR015030Retinoblastoma-associated protein, C-terminal
IPR024599Retinoblastoma-associated protein, N-terminal
IPR028309Retinoblastoma protein family

No MapMan annotations defined for this gene.