Gene: ENSMUSG00000021994 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000021994
Transcript Identifier
ENSMUST00000063465
Gene Type
Coding gene
Location
14 : 28506109-28522940 : positive

Family Information

Homologous gene family
HOM03P001537
(49 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P024443
(4 genes in 3 species)
specific family

Descriptions

gene_descr
wingless-type MMTV integration site family, member 5A

Identifiers

Type Value
UniprotP22725
MGI98958

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000187
ISO
IEA
Genome Projectactivation of MAPK activity
GO:0001667
IMP
Genome Projectameboidal-type cell migration
GO:0001736
IMP
Genome Projectestablishment of planar polarity
GO:0001756
IGI
Genome Projectsomitogenesis
GO:0001819
IDA
Genome Projectpositive regulation of cytokine production
GO:0001837
IEA
Genome Projectepithelial to mesenchymal transition
GO:0001843
IGI
Genome Projectneural tube closure
GO:0001934
IDA
Genome Projectpositive regulation of protein phosphorylation
GO:0001938
ISO
IEA
Genome Projectpositive regulation of endothelial cell proliferation
GO:0001947
IGI
Genome Projectheart looping
GO:0002009
IMP
Genome Projectmorphogenesis of an epithelium
GO:0002053
IMP
Genome Projectpositive regulation of mesenchymal cell proliferation
GO:0002741
ISO
IEA
Genome Projectpositive regulation of cytokine secretion involved in immune response
GO:0003323
IMP
Genome Projecttype B pancreatic cell development
GO:0003344
IGI
Genome Projectpericardium morphogenesis
GO:0003401
IMP
Genome Projectaxis elongation
GO:0003402
IMP, IGI
Genome Projectplanar cell polarity pathway involved in axis elongation
GO:0006468
IGI
Genome Projectprotein phosphorylation
GO:0007165
TAS
Genome Projectsignal transduction
GO:0007223
IDA, IMP
ISO
IEA
Genome ProjectWnt signaling pathway, calcium modulating pathway
GO:0007254
IDA
Genome ProjectJNK cascade
GO:0007257
ISO
IEA
Genome Projectactivation of JUN kinase activity
GO:0007267
TAS
Genome Projectcell-cell signaling
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0007368
IMP
Genome Projectdetermination of left/right symmetry
GO:0007411
IDA
Genome Projectaxon guidance
GO:0007442
IMP
Genome Projecthindgut morphogenesis
GO:0007494
IMP
Genome Projectmidgut development
GO:0008284
IDA, IMP
Genome Projectpositive regulation of cell proliferation
GO:0008584
IMP
IEA
Genome Projectmale gonad development
GO:0008595
IDA
Genome Projectanterior/posterior axis specification, embryo
GO:0009887
TAS
Genome Projectorgan morphogenesis
GO:0009952
IMP
Genome Projectanterior/posterior pattern specification
GO:0010033
IEA
Genome Projectresponse to organic substance
GO:0010595
ISO
IEA
Genome Projectpositive regulation of endothelial cell migration
GO:0010800
IGI
Genome Projectpositive regulation of peptidyl-threonine phosphorylation
GO:0010820
ISO
IEA
Genome Projectpositive regulation of T cell chemotaxis
GO:0010976
IDA
Genome Projectpositive regulation of neuron projection development
GO:0016055
IGI
ISO
IEA
Genome ProjectWnt signaling pathway
GO:0016477
IMP, IGI
Genome Projectcell migration
GO:0021891
IMP
Genome Projectolfactory bulb interneuron development
GO:0021915
IGI
Genome Projectneural tube development
GO:0030154
IEA
Genome Projectcell differentiation
GO:0030216
IEA
Genome Projectkeratinocyte differentiation
GO:0030324
IMP
Genome Projectlung development
GO:0030326
IMP
Genome Projectembryonic limb morphogenesis
GO:0030514
IMP
Genome Projectnegative regulation of BMP signaling pathway
GO:0030825
ISO
IEA
Genome Projectpositive regulation of cGMP metabolic process
GO:0030901
IGI
Genome Projectmidbrain development
GO:0032148
ISO
IEA
Genome Projectactivation of protein kinase B activity
GO:0032729
IMP
Genome Projectpositive regulation of interferon-gamma production
GO:0032755
IDA
ISO
IEA
Genome Projectpositive regulation of interleukin-6 production
GO:0032880
IDA
Genome Projectregulation of protein localization
GO:0033138
IGI
Genome Projectpositive regulation of peptidyl-serine phosphorylation
GO:0034613
IMP
ISO
IEA
Genome Projectcellular protein localization
GO:0035108
IMP
Genome Projectlimb morphogenesis
GO:0035567
IDA
Genome Projectnon-canonical Wnt signaling pathway
GO:0036342
IMP, IGI
Genome Projectpost-anal tail morphogenesis
GO:0038031
IMP
Genome Projectnon-canonical Wnt signaling pathway via JNK cascade
GO:0040037
IMP
Genome Projectnegative regulation of fibroblast growth factor receptor signaling pathway
GO:0042060
ISO
IEA
Genome Projectwound healing
GO:0042472
IDA, IMP
Genome Projectinner ear morphogenesis
GO:0042733
IMP
Genome Projectembryonic digit morphogenesis
GO:0043032
ISO
IEA
Genome Projectpositive regulation of macrophage activation
GO:0043066
ISO
IEA
Genome Projectnegative regulation of apoptotic process
GO:0043507
IDA, IMP
Genome Projectpositive regulation of JUN kinase activity
GO:0045080
ISO
IEA
Genome Projectpositive regulation of chemokine biosynthetic process
GO:0045165
IBA
Genome Projectcell fate commitment
GO:0045198
IGI
Genome Projectestablishment of epithelial cell apical/basal polarity
GO:0045599
ISO
IEA
Genome Projectnegative regulation of fat cell differentiation
GO:0045732
ISO
IEA
Genome Projectpositive regulation of protein catabolic process
GO:0045766
ISO
IEA
Genome Projectpositive regulation of angiogenesis
GO:0045778
ISO
IEA
Genome Projectpositive regulation of ossification
GO:0045807
IDA
Genome Projectpositive regulation of endocytosis
GO:0045836
IGI
Genome Projectpositive regulation of meiotic nuclear division
GO:0045892
ISO
IEA
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045893
IDA
ISO
IEA
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045944
ISO
IEA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046330
IMP
Genome Projectpositive regulation of JNK cascade
GO:0046546
IMP
Genome Projectdevelopment of primary male sexual characteristics
GO:0048022
IDA
Genome Projectnegative regulation of melanin biosynthetic process
GO:0048146
ISO
IEA
Genome Projectpositive regulation of fibroblast proliferation
GO:0048341
IGI
Genome Projectparaxial mesoderm formation
GO:0048546
IMP
Genome Projectdigestive tract morphogenesis
GO:0048570
IGI
Genome Projectnotochord morphogenesis
GO:0048706
ISO
IEA
Genome Projectembryonic skeletal system development
GO:0048806
ISO
IEA
Genome Projectgenitalia development
GO:0048812
IDA
Genome Projectneuron projection morphogenesis
GO:0048843
IGI
Genome Projectnegative regulation of axon extension involved in axon guidance
GO:0048850
IMP
Genome Projecthypophysis morphogenesis
GO:0050679
IMP
Genome Projectpositive regulation of epithelial cell proliferation
GO:0050680
IDA, IMP
Genome Projectnegative regulation of epithelial cell proliferation
GO:0050718
IDA
ISO
IEA
Genome Projectpositive regulation of interleukin-1 beta secretion
GO:0050729
ISO
IEA
Genome Projectpositive regulation of inflammatory response
GO:0050919
IGI
Genome Projectnegative chemotaxis
GO:0051092
ISO
IEA
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0051216
IEA
Genome Projectcartilage development
GO:0051964
IDA
Genome Projectnegative regulation of synapse assembly
GO:0060021
ISO
IEA
Genome Projectpalate development
GO:0060026
IMP
Genome Projectconvergent extension
GO:0060028
IMP, IGI
Genome Projectconvergent extension involved in axis elongation
GO:0060029
IGI
Genome Projectconvergent extension involved in organogenesis
GO:0060065
IMP
Genome Projectuterus development
GO:0060067
IMP
Genome Projectcervix development
GO:0060068
IMP
Genome Projectvagina development
GO:0060070
IDA, IMP, IGI
Genome Projectcanonical Wnt signaling pathway
GO:0060071
IDA, IMP, IGI
ISO
Genome ProjectWnt signaling pathway, planar cell polarity pathway
GO:0060157
IMP
Genome Projecturinary bladder development
GO:0060324
ISO
IEA
Genome Projectface development
GO:0060340
ISO
IEA
Genome Projectpositive regulation of type I interferon-mediated signaling pathway
GO:0060599
IDA
Genome Projectlateral sprouting involved in mammary gland duct morphogenesis
GO:0060606
IMP
Genome Projecttube closure
GO:0060638
IMP
Genome Projectmesenchymal-epithelial cell signaling
GO:0060686
IMP
Genome Projectnegative regulation of prostatic bud formation
GO:0060744
IDA
Genome Projectmammary gland branching involved in thelarche
GO:0060750
IDA
Genome Projectepithelial cell proliferation involved in mammary gland duct elongation
GO:0060760
ISO
IEA
Genome Projectpositive regulation of response to cytokine stimulus
GO:0060762
IDA, IGI
Genome Projectregulation of branching involved in mammary gland duct morphogenesis
GO:0060775
IGI
Genome Projectplanar cell polarity pathway involved in gastrula mediolateral intercalation
GO:0060809
IGI
Genome Projectmesodermal to mesenchymal transition involved in gastrulation
GO:0060907
ISO
IEA
Genome Projectpositive regulation of macrophage cytokine production
GO:0061036
IDA, IMP
Genome Projectpositive regulation of cartilage development
GO:0061053
IGI
Genome Projectsomite development
GO:0061347
IMP
Genome Projectplanar cell polarity pathway involved in outflow tract morphogenesis
GO:0061348
IMP
Genome Projectplanar cell polarity pathway involved in ventricular septum morphogenesis
GO:0061349
IMP
Genome Projectplanar cell polarity pathway involved in cardiac right atrium morphogenesis
GO:0061350
IMP
Genome Projectplanar cell polarity pathway involved in cardiac muscle tissue morphogenesis
GO:0061354
IMP
Genome Projectplanar cell polarity pathway involved in pericardium morphogenesis
GO:0070245
IMP
Genome Projectpositive regulation of thymocyte apoptotic process
GO:0071219
IDA
Genome Projectcellular response to molecule of bacterial origin
GO:0071222
IEA
Genome Projectcellular response to lipopolysaccharide
GO:0071277
IEA
Genome Projectcellular response to calcium ion
GO:0071346
IEA
Genome Projectcellular response to interferon-gamma
GO:0071425
IDA, IMP
ISO
IEA
Genome Projecthematopoietic stem cell proliferation
GO:0071542
IDA, IMP, IGI
Genome Projectdopaminergic neuron differentiation
GO:0071560
IEA
Genome Projectcellular response to transforming growth factor beta stimulus
GO:0072201
ISO
IEA
Genome Projectnegative regulation of mesenchymal cell proliferation
GO:0090009
IGI
Genome Projectprimitive streak formation
GO:0090037
ISO
IEA
Genome Projectpositive regulation of protein kinase C signaling
GO:0090090
IDA, IMP, IGI
ISO
IEA
Genome Projectnegative regulation of canonical Wnt signaling pathway
GO:0090103
IMP, IGI
Genome Projectcochlea morphogenesis
GO:0090179
IMP
Genome Projectplanar cell polarity pathway involved in neural tube closure
GO:0097325
IDA
Genome Projectmelanocyte proliferation
GO:1900020
ISO
IEA
Genome Projectpositive regulation of protein kinase C activity
GO:2000049
IDA
Genome Projectpositive regulation of cell-cell adhesion mediated by cadherin
GO:2000052
IDA
Genome Projectpositive regulation of non-canonical Wnt signaling pathway
GO:2000484
IDA
Genome Projectpositive regulation of interleukin-8 secretion

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0003700
ISS, ISO
IEA
Genome Projecttranscription factor activity, sequence-specific DNA binding
GO:0005102
IPI
TAS, IEA
Genome Projectreceptor binding
GO:0005109
IPI
ISO
IEA
Genome Projectfrizzled binding
GO:0005110
IDA
Genome Projectfrizzled-2 binding
GO:0005115
ISO
IEA
Genome Projectreceptor tyrosine kinase-like orphan receptor binding
GO:0005125
IDA
Genome Projectcytokine activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0019904
IPI
Genome Projectprotein domain specific binding
GO:0044212
ISO
IEA
Genome Projecttranscription regulatory region DNA binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
TAS, IEA
Genome Projectextracellular region
GO:0005578
IDA
IEA
Genome Projectproteinaceous extracellular matrix
GO:0005615
ISO, IBA
IEA
Genome Projectextracellular space
GO:0005788
TAS
Genome Projectendoplasmic reticulum lumen
GO:0009986
IDA
Genome Projectcell surface

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR005817Wnt
IPR018161Wnt protein, conserved site
IPR026538Wnt-5a protein

No MapMan annotations defined for this gene.