Gene: ENSMUSG00000021835 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000021835
Transcript Identifier
ENSMUST00000100676
Gene Type
Coding gene
Location
14 : 46383859-46386087 : negative

Family Information

Homologous gene family
HOM03P001000
(62 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P063641
(2 genes in 2 species)
specific family

Descriptions

gene_descr
bone morphogenetic protein 4

Identifiers

Type Value
UniprotP21275
UniprotQ3ULR1
MGI88180

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000122
IDA
ISO
IEA
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0000186
ISS, ISO
IEA
Genome Projectactivation of MAPKK activity
GO:0001501
IDA, IMP
Genome Projectskeletal system development
GO:0001503
IEA
Genome Projectossification
GO:0001525
IMP
Genome Projectangiogenesis
GO:0001541
IEA
Genome Projectovarian follicle development
GO:0001568
IDA
Genome Projectblood vessel development
GO:0001649
IDA
ISS, ISO
IEA
Genome Projectosteoblast differentiation
GO:0001656
IDA, IMP
Genome Projectmetanephros development
GO:0001657
IDA, IMP
ISO
IEA
Genome Projectureteric bud development
GO:0001658
IGI
ISS, ISO
IEA
Genome Projectbranching involved in ureteric bud morphogenesis
GO:0001707
IDA
Genome Projectmesoderm formation
GO:0001759
IMP
Genome Projectorgan induction
GO:0001822
IMP, IGI
ISS, ISO
IEA
Genome Projectkidney development
GO:0001823
ISS
IEA
Genome Projectmesonephros development
GO:0001843
IDA
Genome Projectneural tube closure
GO:0001934
IMP
ISO
IEA
Genome Projectpositive regulation of protein phosphorylation
GO:0001936
TAS
Genome Projectregulation of endothelial cell proliferation
GO:0001938
IDA
ISS, ISO
IEA
Genome Projectpositive regulation of endothelial cell proliferation
GO:0001944
IMP
Genome Projectvasculature development
GO:0001958
IMP
Genome Projectendochondral ossification
GO:0002043
ISS, ISO
IEA
Genome Projectblood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:0002062
IMP
Genome Projectchondrocyte differentiation
GO:0002244
IDA
ISS, ISO
IEA
Genome Projecthematopoietic progenitor cell differentiation
GO:0002320
ISS, ISO
IEA
Genome Projectlymphoid progenitor cell differentiation
GO:0003014
IMP
Genome Projectrenal system process
GO:0003130
ISS, ISO
IEA
Genome ProjectBMP signaling pathway involved in heart induction
GO:0003139
ISS, ISO
IEA
Genome Projectsecondary heart field specification
GO:0003323
ISS, ISO
IEA
Genome Projecttype B pancreatic cell development
GO:0003337
ISS, ISO
IEA
Genome Projectmesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0007182
ISS, ISO
IEA
Genome Projectcommon-partner SMAD protein phosphorylation
GO:0007224
IEA
Genome Projectsmoothened signaling pathway
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0007281
IMP
Genome Projectgerm cell development
GO:0007420
IEA
Genome Projectbrain development
GO:0007500
IMP
Genome Projectmesodermal cell fate determination
GO:0007507
IMP
Genome Projectheart development
GO:0008284
IMP
IEA
Genome Projectpositive regulation of cell proliferation
GO:0008285
IGI
ISO
IEA
Genome Projectnegative regulation of cell proliferation
GO:0009612
IEA
Genome Projectresponse to mechanical stimulus
GO:0009791
IMP
ISO
IEA
Genome Projectpost-embryonic development
GO:0009888
IGI
Genome Projecttissue development
GO:0009948
IGI
Genome Projectanterior/posterior axis specification
GO:0010159
IMP
Genome Projectspecification of organ position
GO:0010453
ISS, ISO
IEA
Genome Projectregulation of cell fate commitment
GO:0010468
IDA, IMP
Genome Projectregulation of gene expression
GO:0010524
IEA
Genome Projectpositive regulation of calcium ion transport into cytosol
GO:0010595
ISS, ISO
TAS, IEA
Genome Projectpositive regulation of endothelial cell migration
GO:0010628
IDA, IMP
Genome Projectpositive regulation of gene expression
GO:0010629
IDA
Genome Projectnegative regulation of gene expression
GO:0010862
ISS, ISO, IBA
IEA
Genome Projectpositive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010942
ISO
IEA
Genome Projectpositive regulation of cell death
GO:0010976
IEA
Genome Projectpositive regulation of neuron projection development
GO:0014070
IEA
Genome Projectresponse to organic cyclic compound
GO:0021537
ISO
IEA
Genome Projecttelencephalon development
GO:0021904
IDA
Genome Projectdorsal/ventral neural tube patterning
GO:0021978
IDA, IGI
Genome Projecttelencephalon regionalization
GO:0021983
IMP
Genome Projectpituitary gland development
GO:0030154
IEA
Genome Projectcell differentiation
GO:0030218
IDA
Genome Projecterythrocyte differentiation
GO:0030224
ISO
IEA
Genome Projectmonocyte differentiation
GO:0030225
ISO
IEA
Genome Projectmacrophage differentiation
GO:0030324
IMP
Genome Projectlung development
GO:0030326
IMP, IGI
Genome Projectembryonic limb morphogenesis
GO:0030335
IMP
Genome Projectpositive regulation of cell migration
GO:0030501
ISS, ISO
IEA
Genome Projectpositive regulation of bone mineralization
GO:0030509
IDA, IGI
ISS, ISO
IEA
Genome ProjectBMP signaling pathway
GO:0030513
IDA
Genome Projectpositive regulation of BMP signaling pathway
GO:0030900
IMP, IGI
Genome Projectforebrain development
GO:0030949
TAS
Genome Projectpositive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032092
ISO
IEA
Genome Projectpositive regulation of protein binding
GO:0032331
IDA
Genome Projectnegative regulation of chondrocyte differentiation
GO:0032355
IEA
Genome Projectresponse to estradiol
GO:0032526
IEA
Genome Projectresponse to retinoic acid
GO:0032967
ISS, ISO
IEA
Genome Projectpositive regulation of collagen biosynthetic process
GO:0033085
ISO
IEA
Genome Projectnegative regulation of T cell differentiation in thymus
GO:0033088
ISS, ISO
IEA
Genome Projectnegative regulation of immature T cell proliferation in thymus
GO:0033574
IEA
Genome Projectresponse to testosterone
GO:0034504
ISS, ISO
IEA
Genome Projectprotein localization to nucleus
GO:0034599
IEA
Genome Projectcellular response to oxidative stress
GO:0035116
IGI
Genome Projectembryonic hindlimb morphogenesis
GO:0035990
IMP
Genome Projecttendon cell differentiation
GO:0035993
IMP
Genome Projectdeltoid tuberosity development
GO:0040007
IEA
Genome Projectgrowth
GO:0042060
IEA
Genome Projectwound healing
GO:0042306
ISO
IEA
Genome Projectregulation of protein import into nucleus
GO:0042326
ISS, ISO
IEA
Genome Projectnegative regulation of phosphorylation
GO:0042475
IDA, IGI
Genome Projectodontogenesis of dentin-containing tooth
GO:0042476
ISS, ISO
IEA
Genome Projectodontogenesis
GO:0042487
IGI
Genome Projectregulation of odontogenesis of dentin-containing tooth
GO:0042733
IGI
Genome Projectembryonic digit morphogenesis
GO:0043010
IMP, IGI
Genome Projectcamera-type eye development
GO:0043065
ISS, ISO
IEA
Genome Projectpositive regulation of apoptotic process
GO:0043066
IMP
ISS, ISO
IEA
Genome Projectnegative regulation of apoptotic process
GO:0043401
ISS, ISO
IEA
Genome Projectsteroid hormone mediated signaling pathway
GO:0043407
ISS, ISO
IEA
Genome Projectnegative regulation of MAP kinase activity
GO:0043587
IEA
Genome Projecttongue morphogenesis
GO:0045165
IDA
Genome Projectcell fate commitment
GO:0045595
IGI
IEA
Genome Projectregulation of cell differentiation
GO:0045597
IDA
Genome Projectpositive regulation of cell differentiation
GO:0045603
IDA
Genome Projectpositive regulation of endothelial cell differentiation
GO:0045606
ISS, ISO
IEA
Genome Projectpositive regulation of epidermal cell differentiation
GO:0045662
ISO
IEA
Genome Projectnegative regulation of myoblast differentiation
GO:0045666
IDA
IEA
Genome Projectpositive regulation of neuron differentiation
GO:0045669
ISS, ISO
IEA
Genome Projectpositive regulation of osteoblast differentiation
GO:0045778
IDA
ISO
IEA
Genome Projectpositive regulation of ossification
GO:0045786
ISS, ISO
IEA
Genome Projectnegative regulation of cell cycle
GO:0045839
ISS, ISO
IEA
Genome Projectnegative regulation of mitotic nuclear division
GO:0045843
ISO
IEA
Genome Projectnegative regulation of striated muscle tissue development
GO:0045892
ISS, ISO
IEA
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045893
ISS, ISO
TAS, IEA
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045944
IDA, IMP, IGI
ISO
IEA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0048286
ISO
IEA
Genome Projectlung alveolus development
GO:0048333
IDA
Genome Projectmesodermal cell differentiation
GO:0048392
ISS, ISO
IEA
Genome Projectintermediate mesodermal cell differentiation
GO:0048593
IMP
Genome Projectcamera-type eye morphogenesis
GO:0048598
IMP
Genome Projectembryonic morphogenesis
GO:0048646
IGI
Genome Projectanatomical structure formation involved in morphogenesis
GO:0048660
IDA
Genome Projectregulation of smooth muscle cell proliferation
GO:0048661
ISS, ISO
IEA
Genome Projectpositive regulation of smooth muscle cell proliferation
GO:0048663
IDA, IMP
Genome Projectneuron fate commitment
GO:0048701
IMP
Genome Projectembryonic cranial skeleton morphogenesis
GO:0048704
IMP
Genome Projectembryonic skeletal system morphogenesis
GO:0048706
IMP
Genome Projectembryonic skeletal system development
GO:0048715
IEA
Genome Projectnegative regulation of oligodendrocyte differentiation
GO:0048745
IMP
Genome Projectsmooth muscle tissue development
GO:0048754
ISS, ISO
IEA
Genome Projectbranching morphogenesis of an epithelial tube
GO:0050679
ISS, ISO
IEA
Genome Projectpositive regulation of epithelial cell proliferation
GO:0050680
IMP
Genome Projectnegative regulation of epithelial cell proliferation
GO:0050918
ISS, ISO
IEA
Genome Projectpositive chemotaxis
GO:0051145
IDA
Genome Projectsmooth muscle cell differentiation
GO:0051150
IDA, IGI
Genome Projectregulation of smooth muscle cell differentiation
GO:0051216
IEA
Genome Projectcartilage development
GO:0051384
IEA
Genome Projectresponse to glucocorticoid
GO:0055007
NAS
Genome Projectcardiac muscle cell differentiation
GO:0055020
ISS, ISO
IEA
Genome Projectpositive regulation of cardiac muscle fiber development
GO:0060033
IEA
Genome Projectanatomical structure regression
GO:0060113
IGI
Genome Projectinner ear receptor cell differentiation
GO:0060197
IEP
Genome Projectcloacal septation
GO:0060235
IMP
Genome Projectlens induction in camera-type eye
GO:0060272
IMP, IGI
Genome Projectembryonic skeletal joint morphogenesis
GO:0060348
IDA
Genome Projectbone development
GO:0060363
IDA
Genome Projectcranial suture morphogenesis
GO:0060391
ISS, ISO
IEA
Genome Projectpositive regulation of SMAD protein import into nucleus
GO:0060393
ISS, ISO
IEA
Genome Projectregulation of pathway-restricted SMAD protein phosphorylation
GO:0060395
IDA
ISS, ISO
IEA
Genome ProjectSMAD protein signal transduction
GO:0060425
ISO
IEA
Genome Projectlung morphogenesis
GO:0060429
IDA
Genome Projectepithelium development
GO:0060433
ISO
IEA
Genome Projectbronchus development
GO:0060438
ISO
IEA
Genome Projecttrachea development
GO:0060440
IMP
Genome Projecttrachea formation
GO:0060441
ISO
IEA
Genome Projectepithelial tube branching involved in lung morphogenesis
GO:0060442
IMP
Genome Projectbranching involved in prostate gland morphogenesis
GO:0060449
IDA
Genome Projectbud elongation involved in lung branching
GO:0060462
IEA
Genome Projectlung lobe development
GO:0060502
ISO
IEA
Genome Projectepithelial cell proliferation involved in lung morphogenesis
GO:0060503
ISO
IEA
Genome Projectbud dilation involved in lung branching
GO:0060512
IMP
Genome Projectprostate gland morphogenesis
GO:0060548
ISS, ISO
IEA
Genome Projectnegative regulation of cell death
GO:0060592
IMP
Genome Projectmammary gland formation
GO:0060684
IDA
Genome Projectepithelial-mesenchymal cell signaling
GO:0060686
IDA, IMP
Genome Projectnegative regulation of prostatic bud formation
GO:0060687
IMP
Genome Projectregulation of branching involved in prostate gland morphogenesis
GO:0060688
IMP
Genome Projectregulation of morphogenesis of a branching structure
GO:0061035
IDA
Genome Projectregulation of cartilage development
GO:0061036
ISO
IEA
Genome Projectpositive regulation of cartilage development
GO:0061047
IMP
Genome Projectpositive regulation of branching involved in lung morphogenesis
GO:0061149
IDA
Genome ProjectBMP signaling pathway involved in ureter morphogenesis
GO:0061151
IMP
Genome ProjectBMP signaling pathway involved in renal system segmentation
GO:0061155
ISS, ISO
IEA
Genome Projectpulmonary artery endothelial tube morphogenesis
GO:0070244
ISS, ISO
IEA
Genome Projectnegative regulation of thymocyte apoptotic process
GO:0070368
IEA
Genome Projectpositive regulation of hepatocyte differentiation
GO:0070372
IEA
Genome Projectregulation of ERK1 and ERK2 cascade
GO:0070374
IDA
Genome Projectpositive regulation of ERK1 and ERK2 cascade
GO:0071260
IEA
Genome Projectcellular response to mechanical stimulus
GO:0071363
IDA
Genome Projectcellular response to growth factor stimulus
GO:0071731
IEA
Genome Projectresponse to nitric oxide
GO:0071773
ISO
IEA
Genome Projectcellular response to BMP stimulus
GO:0071893
ISS, ISO
IEA
Genome ProjectBMP signaling pathway involved in nephric duct formation
GO:0072001
IGI
IEA
Genome Projectrenal system development
GO:0072015
IEP
Genome Projectglomerular visceral epithelial cell development
GO:0072097
ISS, ISO
IEA
Genome Projectnegative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway
GO:0072101
ISS, ISO
IEA
Genome Projectspecification of ureteric bud anterior/posterior symmetry by BMP signaling pathway
GO:0072104
IMP
Genome Projectglomerular capillary formation
GO:0072125
ISS, ISO
IEA
Genome Projectnegative regulation of glomerular mesangial cell proliferation
GO:0072138
IEP
Genome Projectmesenchymal cell proliferation involved in ureteric bud development
GO:0072161
IMP
Genome Projectmesenchymal cell differentiation involved in kidney development
GO:0072192
IMP
Genome Projectureter epithelial cell differentiation
GO:0072193
IMP
Genome Projectureter smooth muscle cell differentiation
GO:0072198
IEP
Genome Projectmesenchymal cell proliferation involved in ureter development
GO:0072200
ISS, ISO
IEA
Genome Projectnegative regulation of mesenchymal cell proliferation involved in ureter development
GO:0072205
IMP
Genome Projectmetanephric collecting duct development
GO:0090184
ISS, ISO
IEA
Genome Projectpositive regulation of kidney development
GO:0090191
IDA
ISS, ISO
IEA
Genome Projectnegative regulation of branching involved in ureteric bud morphogenesis
GO:0090194
ISS, ISO
IEA
Genome Projectnegative regulation of glomerulus development
GO:0097067
IEA
Genome Projectcellular response to thyroid hormone stimulus
GO:1901341
IEA
Genome Projectpositive regulation of store-operated calcium channel activity
GO:1902462
IEA
Genome Projectpositive regulation of mesenchymal stem cell proliferation
GO:2000005
ISS, ISO
IEA
Genome Projectnegative regulation of metanephric S-shaped body morphogenesis
GO:2000007
ISS, ISO
IEA
Genome Projectnegative regulation of metanephric comma-shaped body morphogenesis
GO:2000105
ISS, ISO
IEA
Genome Projectpositive regulation of DNA-dependent DNA replication
GO:2000137
ISS, ISO
IEA
Genome Projectnegative regulation of cell proliferation involved in heart morphogenesis
GO:2000353
IEA
Genome Projectpositive regulation of endothelial cell apoptotic process
GO:2001012
IMP
Genome Projectmesenchymal cell differentiation involved in renal system development
GO:0001654
IGI
Genome Projecteye development
GO:0060041
IEA
Genome Projectretina development in camera-type eye

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005125
ISO, IBA
IEA
Genome Projectcytokine activity
GO:0005160
IBA
Genome Projecttransforming growth factor beta receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008083
IEA
Genome Projectgrowth factor activity
GO:0008201
IDA
Genome Projectheparin binding
GO:0039706
ISO
Genome Projectco-receptor binding
GO:0042056
ISS, ISO
IEA
Genome Projectchemoattractant activity
GO:0042803
IEA
Genome Projectprotein homodimerization activity
GO:0070700
ISS, ISO, IBA
IEA
Genome ProjectBMP receptor binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
IDA
IEA
Genome Projectextracellular region
GO:0005578
IEA
Genome Projectproteinaceous extracellular matrix
GO:0005615
IDA
ISO
IEA
Genome Projectextracellular space
GO:0005737
IEA
Genome Projectcytoplasm
GO:0031988
IEA
Genome Projectmembrane-bounded vesicle

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001111Transforming growth factor-beta, N-terminal
IPR001839Transforming growth factor-beta, C-terminal
IPR017948Transforming growth factor beta, conserved site
IPR029034Cystine-knot cytokine

No MapMan annotations defined for this gene.