Gene: ENSMUSG00000021756 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000021756
Transcript Identifier
ENSMUST00000070731
Gene Type
Coding gene
Location
13 : 112475046-112504445 : positive

Family Information

Homologous gene family
HOM03P010213
(8 genes in 2 species)
specific family
Orthologous gene family
ORTHO03P076275
(2 genes in 2 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
interleukin 6 signal transducer

Identifiers

Type Value
UniprotQ00560
MGI96560

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005977
IMP
Genome Projectglycogen metabolic process
GO:0007165
IDA
Genome Projectsignal transduction
GO:0008284
IGI
ISO
IEA
Genome Projectpositive regulation of cell proliferation
GO:0008593
IDA
Genome Projectregulation of Notch signaling pathway
GO:0019221
IDA
ISO
IEA
Genome Projectcytokine-mediated signaling pathway
GO:0034097
ISO
IEA
Genome Projectresponse to cytokine
GO:0038154
IDA
Genome Projectinterleukin-11-mediated signaling pathway
GO:0038165
ISO
IEA
Genome Projectoncostatin-M-mediated signaling pathway
GO:0042102
ISO
IEA
Genome Projectpositive regulation of T cell proliferation
GO:0042511
ISO
IEA
Genome Projectpositive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517
ISO
IEA
Genome Projectpositive regulation of tyrosine phosphorylation of Stat3 protein
GO:0045669
ISO
IEA
Genome Projectpositive regulation of osteoblast differentiation
GO:0048711
IMP
Genome Projectpositive regulation of astrocyte differentiation
GO:0048861
ISO
IEA
Genome Projectleukemia inhibitory factor signaling pathway
GO:0070102
ISO
IEA
Genome Projectinterleukin-6-mediated signaling pathway
GO:0070104
ISO
IEA
Genome Projectnegative regulation of interleukin-6-mediated signaling pathway
GO:0070106
ISO
IEA
Genome Projectinterleukin-27-mediated signaling pathway
GO:0070120
ISO
IEA
Genome Projectciliary neurotrophic factor-mediated signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004896
IEA
Genome Projectcytokine receptor activity
GO:0004897
ISO
IEA
Genome Projectciliary neurotrophic factor receptor activity
GO:0004915
ISO
IEA
Genome Projectinterleukin-6 receptor activity
GO:0004923
ISO
IEA
Genome Projectleukemia inhibitory factor receptor activity
GO:0004924
ISO
IEA
Genome Projectoncostatin-M receptor activity
GO:0005127
ISO
IEA
Genome Projectciliary neurotrophic factor receptor binding
GO:0005138
ISO
IEA
Genome Projectinterleukin-6 receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0019838
ISO
IEA
Genome Projectgrowth factor binding
GO:0019981
ISO
IEA
Genome Projectinterleukin-6 binding
GO:0004921
IDA
Genome Projectinterleukin-11 receptor activity
GO:0019970
IDA
Genome Projectinterleukin-11 binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005615
ISO
IEA
Genome Projectextracellular space
GO:0005896
ISO
IEA
Genome Projectinterleukin-6 receptor complex
GO:0005900
ISO
IEA
Genome Projectoncostatin-M receptor complex
GO:0009897
IDA
Genome Projectexternal side of plasma membrane
GO:0016020
ISO
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0030425
IDA
Genome Projectdendrite
GO:0043025
IDA
Genome Projectneuronal cell body
GO:0044297
IDA
Genome Projectcell body
GO:0070062
ISO
IEA
Genome Projectextracellular exosome
GO:0070110
ISO
IEA
Genome Projectciliary neurotrophic factor receptor complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR003529Long hematopoietin receptor, Gp130 family 2, conserved site
IPR003961Fibronectin type III
IPR010457Immunoglobulin C2-set-like, ligand-binding
IPR013783Immunoglobulin-like fold
IPR015321Type I cytokine receptor, cytokine-binding domain

No MapMan annotations defined for this gene.