Gene: ENSMUSG00000021466 (Mus musculus)

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Gene Identifier
ENSMUSG00000021466
Transcript Identifier
ENSMUST00000021921
Gene Type
Coding gene
Location
13 : 63511533-63565520 : negative

Family Information

Homologous gene family
HOM03P000381
(116 genes in 33 species)
specific family
Orthologous gene family
ORTHO03P010307
(8 genes in 4 species)
specific family

Descriptions

gene_descr
patched homolog 1

Identifiers

Type Value
UniprotQ61115
MGI105373

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000122
ISO
IEA
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0001658
IMP
Genome Projectbranching involved in ureteric bud morphogenesis
GO:0001701
IGI
Genome Projectin utero embryonic development
GO:0001709
IGI
Genome Projectcell fate determination
GO:0001841
IDA
Genome Projectneural tube formation
GO:0001843
IMP
Genome Projectneural tube closure
GO:0003007
IMP
Genome Projectheart morphogenesis
GO:0007165
IDA
Genome Projectsignal transduction
GO:0007224
IDA, IGI
Genome Projectsmoothened signaling pathway
GO:0007346
IMP
Genome Projectregulation of mitotic cell cycle
GO:0007389
IMP
Genome Projectpattern specification process
GO:0007420
IMP
Genome Projectbrain development
GO:0008285
IMP
Genome Projectnegative regulation of cell proliferation
GO:0008544
IMP
Genome Projectepidermis development
GO:0008589
IMP, IGI
Genome Projectregulation of smoothened signaling pathway
GO:0009612
IEA
Genome Projectresponse to mechanical stimulus
GO:0009887
IMP
Genome Projectorgan morphogenesis
GO:0009953
IGI
Genome Projectdorsal/ventral pattern formation
GO:0009957
IGI
Genome Projectepidermal cell fate specification
GO:0010157
IDA
Genome Projectresponse to chlorate
GO:0010875
ISO
IEA
Genome Projectpositive regulation of cholesterol efflux
GO:0014070
IEA
Genome Projectresponse to organic cyclic compound
GO:0016485
IMP
Genome Projectprotein processing
GO:0021522
IGI
Genome Projectspinal cord motor neuron differentiation
GO:0021532
ISO
IEA
Genome Projectneural tube patterning
GO:0021904
IMP
Genome Projectdorsal/ventral neural tube patterning
GO:0021997
IMP
Genome Projectneural plate axis specification
GO:0030326
IMP, IGI
Genome Projectembryonic limb morphogenesis
GO:0030879
IMP
Genome Projectmammary gland development
GO:0032355
IEA
Genome Projectresponse to estradiol
GO:0032526
IEA
Genome Projectresponse to retinoic acid
GO:0032880
IDA, IMP
Genome Projectregulation of protein localization
GO:0035108
ISO
IEA
Genome Projectlimb morphogenesis
GO:0035137
IMP
Genome Projecthindlimb morphogenesis
GO:0040008
IMP
Genome Projectregulation of growth
GO:0040015
IMP
Genome Projectnegative regulation of multicellular organism growth
GO:0042127
IMP
Genome Projectregulation of cell proliferation
GO:0042493
IEA
Genome Projectresponse to drug
GO:0042593
IMP
Genome Projectglucose homeostasis
GO:0043433
ISO
IEA
Genome Projectnegative regulation of sequence-specific DNA binding transcription factor activity
GO:0043616
IMP
Genome Projectkeratinocyte proliferation
GO:0045606
IGI
Genome Projectpositive regulation of epidermal cell differentiation
GO:0045668
ISO
IEA
Genome Projectnegative regulation of osteoblast differentiation
GO:0045879
IMP, IGI
NAS
Genome Projectnegative regulation of smoothened signaling pathway
GO:0045892
IMP
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045893
IMP
Genome Projectpositive regulation of transcription, DNA-templated
GO:0048568
IGI
Genome Projectembryonic organ development
GO:0050680
IMP
Genome Projectnegative regulation of epithelial cell proliferation
GO:0051782
IMP
Genome Projectnegative regulation of cell division
GO:0060037
ISO
IEA
Genome Projectpharyngeal system development
GO:0060603
IMP
Genome Projectmammary gland duct morphogenesis
GO:0060644
IMP
Genome Projectmammary gland epithelial cell differentiation
GO:0060831
IMP
Genome Projectsmoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:0061005
IGI
Genome Projectcell differentiation involved in kidney development
GO:0061053
IMP
ISO
IEA
Genome Projectsomite development
GO:0071397
IEP
ISO
Genome Projectcellular response to cholesterol
GO:0072001
IEA
Genome Projectrenal system development
GO:0072203
IMP
Genome Projectcell proliferation involved in metanephros development
GO:0072661
ISO
IEA
Genome Projectprotein targeting to plasma membrane

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005113
IDA
Genome Projectpatched binding
GO:0005119
ISO
IEA
Genome Projectsmoothened binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008158
TAS, IEA
Genome Projecthedgehog receptor activity
GO:0008201
IDA
Genome Projectheparin binding
GO:0008270
NAS
Genome Projectzinc ion binding
GO:0015485
ISO
TAS, IEA
Genome Projectcholesterol binding
GO:0030332
IPI
ISO
IEA
Genome Projectcyclin binding
GO:0032403
IDA
Genome Projectprotein complex binding
GO:0097108
ISO
IEA
Genome Projecthedgehog family protein binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
TAS
Genome Projectextracellular region
GO:0005794
ISO
IEA
Genome ProjectGolgi apparatus
GO:0005886
IDA
ISO
TAS, IEA
Genome Projectplasma membrane
GO:0005887
TAS
Genome Projectintegral component of plasma membrane
GO:0005901
ISO
IEA
Genome Projectcaveola
GO:0014069
IEA
Genome Projectpostsynaptic density
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0030496
IDA
Genome Projectmidbody
GO:0043231
ISO
IEA
Genome Projectintracellular membrane-bounded organelle
GO:0044294
IEA
Genome Projectdendritic growth cone
GO:0044295
IEA
Genome Projectaxonal growth cone
GO:0048471
ISO
IEA
Genome Projectperinuclear region of cytoplasm
GO:0072372
IDA
Genome Projectprimary cilium

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000731Sterol-sensing domain
IPR003392Patched
IPR004766Transmembrane receptor, patched

No MapMan annotations defined for this gene.