Gene: ENSMUSG00000021408 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000021408
Transcript Identifier
ENSMUST00000167374
Gene Type
Coding gene
Location
13 : 34009657-34032782 : positive

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P068712
(2 genes in 2 species)
specific family

Descriptions

gene_descr
receptor (TNFRSF)-interacting serine-threonine kinase 1

Identifiers

Type Value
UniprotQ60855
MGI108212

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001934
ISS, ISO
IEA
Genome Projectpositive regulation of protein phosphorylation
GO:0006468
IEA
Genome Projectprotein phosphorylation
GO:0006915
ISS, ISO
IEA
Genome Projectapoptotic process
GO:0007165
IEA
Genome Projectsignal transduction
GO:0010942
IEA
Genome Projectpositive regulation of cell death
GO:0012501
IEA
Genome Projectprogrammed cell death
GO:0016032
IEA
Genome Projectviral process
GO:0016310
IEA
Genome Projectphosphorylation
GO:0032757
ISO
IEA
Genome Projectpositive regulation of interleukin-8 production
GO:0032760
ISO
IEA
Genome Projectpositive regulation of tumor necrosis factor production
GO:0034612
ISO
IEA
Genome Projectresponse to tumor necrosis factor
GO:0036289
ISS, ISO
IEA
Genome Projectpeptidyl-serine autophosphorylation
GO:0042327
IMP
Genome Projectpositive regulation of phosphorylation
GO:0043065
ISS, ISO
IEA
Genome Projectpositive regulation of apoptotic process
GO:0043068
ISO
IEA
Genome Projectpositive regulation of programmed cell death
GO:0043123
IMP
ISS, ISO
IEA
Genome Projectpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124
ISO
IEA
Genome Projectnegative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043410
IMP
Genome Projectpositive regulation of MAPK cascade
GO:0044257
ISS, ISO
IEA
Genome Projectcellular protein catabolic process
GO:0045651
ISO
IEA
Genome Projectpositive regulation of macrophage differentiation
GO:0045944
ISS, ISO
IEA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046330
IMP
ISO
IEA
Genome Projectpositive regulation of JNK cascade
GO:0046777
ISO
IEA
Genome Projectprotein autophosphorylation
GO:0051092
IMP
ISO
IEA
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0051260
ISS, ISO
IEA
Genome Projectprotein homooligomerization
GO:0051291
ISS, ISO
IEA
Genome Projectprotein heterooligomerization
GO:0060545
ISO
IEA
Genome Projectpositive regulation of necroptotic process
GO:0070231
IMP
Genome ProjectT cell apoptotic process
GO:0070266
IGI
ISO
IEA
Genome Projectnecroptotic process
GO:0070926
ISO
IEA
Genome Projectregulation of ATP:ADP antiporter activity
GO:0071356
ISS, ISO
IEA
Genome Projectcellular response to tumor necrosis factor
GO:0071363
IMP
Genome Projectcellular response to growth factor stimulus
GO:0097191
ISO
IEA
Genome Projectextrinsic apoptotic signaling pathway
GO:0097343
ISS, ISO
IEA
Genome Projectripoptosome assembly
GO:0097527
IMP
ISO
Genome Projectnecroptotic signaling pathway
GO:1901026
IGI
Genome Projectripoptosome assembly involved in necroptotic process
GO:1990000
ISS, ISO
IEA
Genome Projectamyloid fibril formation
GO:2000377
IMP
Genome Projectregulation of reactive oxygen species metabolic process
GO:2001237
IGI
ISO
IEA
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway
GO:2001238
IGI
ISO
IEA
Genome Projectpositive regulation of extrinsic apoptotic signaling pathway
GO:2001240
IMP
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
ISS, ISO
IEA
Genome Projectprotein kinase activity
GO:0004674
ISS, ISO
IEA
Genome Projectprotein serine/threonine kinase activity
GO:0005123
ISO
IEA
Genome Projectdeath receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0031625
ISO
IEA
Genome Projectubiquitin protein ligase binding
GO:0032403
ISO
IEA
Genome Projectprotein complex binding
GO:0042802
ISO
IEA
Genome Projectidentical protein binding
GO:0070513
ISO
IEA
Genome Projectdeath domain binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
ISO
IEA
Genome Projectcytoplasm
GO:0005739
ISO
IEA
Genome Projectmitochondrion
GO:0005886
IEA
Genome Projectplasma membrane
GO:0016020
IEA
Genome Projectmembrane
GO:0031264
ISO
IEA
Genome Projectdeath-inducing signaling complex
GO:0043234
IEA
Genome Projectprotein complex
GO:0043235
ISO
IEA
Genome Projectreceptor complex
GO:0045121
IEA
Genome Projectmembrane raft
GO:0097342
IDA
ISO
IEA
Genome Projectripoptosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000488Death domain
IPR000719Protein kinase domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR008271Serine/threonine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR011029Death-like domain
IPR025735RHIM domain

No MapMan annotations defined for this gene.