Gene: ENSMUSG00000021313 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000021313
Transcript Identifier
ENSMUST00000170156
Gene Type
Coding gene
Location
13 : 11554516-12106446 : negative

Family Information

Homologous gene family
HOM03P001263
(54 genes in 8 species)
specific family
Orthologous gene family
ORTHO03P012152
(7 genes in 4 species)
specific family

Descriptions

gene_descr
ryanodine receptor 2, cardiac

Identifiers

Type Value
UniprotF6U7V1
MGI99685

Toolbox

Explore

Create

View

Browse

 

Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0002027
ISO
Genome Projectregulation of heart rate
GO:0003220
IMP
Genome Projectleft ventricular cardiac muscle tissue morphogenesis
GO:0003300
IMP
Genome Projectcardiac muscle hypertrophy
GO:0005513
ISO
Genome Projectdetection of calcium ion
GO:0006810
IEA
Genome Projecttransport
GO:0006811
IEA
Genome Projection transport
GO:0006816
IDA, IPI
ISO
Genome Projectcalcium ion transport
GO:0006874
IEA
Genome Projectcellular calcium ion homeostasis
GO:0010460
IMP
Genome Projectpositive regulation of heart rate
GO:0010882
ISO
Genome Projectregulation of cardiac muscle contraction by calcium ion signaling
GO:0014808
IMP
ISO
Genome Projectrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0014850
ISO
Genome Projectresponse to muscle activity
GO:0030509
IDA
Genome ProjectBMP signaling pathway
GO:0031000
IDA
ISO
Genome Projectresponse to caffeine
GO:0035584
ISO
Genome Projectcalcium-mediated signaling using intracellular calcium source
GO:0035994
ISO
Genome Projectresponse to muscle stretch
GO:0051209
ISO
Genome Projectrelease of sequestered calcium ion into cytosol
GO:0051284
ISO
Genome Projectpositive regulation of sequestering of calcium ion
GO:0051775
ISO
Genome Projectresponse to redox state
GO:0055085
IEA
Genome Projecttransmembrane transport
GO:0055117
ISO
Genome Projectregulation of cardiac muscle contraction
GO:0060048
ISO
Genome Projectcardiac muscle contraction
GO:0060070
IDA
Genome Projectcanonical Wnt signaling pathway
GO:0060401
IMP
Genome Projectcytosolic calcium ion transport
GO:0060402
ISO
Genome Projectcalcium ion transport into cytosol
GO:0070588
IMP
IEA
Genome Projectcalcium ion transmembrane transport
GO:0071313
IDA
ISO
Genome Projectcellular response to caffeine
GO:0072599
ISO
Genome Projectestablishment of protein localization to endoplasmic reticulum
GO:0097050
ISO
Genome Projecttype B pancreatic cell apoptotic process
GO:0098735
ISO
Genome Projectpositive regulation of the force of heart contraction
GO:0098904
ISO
Genome Projectregulation of AV node cell action potential
GO:0098907
ISO
Genome Projectregulation of SA node cell action potential
GO:0098910
ISO
Genome Projectregulation of atrial cardiac muscle cell action potential
GO:0098911
ISO
Genome Projectregulation of ventricular cardiac muscle cell action potential
GO:1901896
ISO
Genome Projectpositive regulation of calcium-transporting ATPase activity

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005216
IEA
Genome Projection channel activity
GO:0005219
IDA
ISO
IEA
Genome Projectryanodine-sensitive calcium-release channel activity
GO:0005262
IEA
Genome Projectcalcium channel activity
GO:0005509
IEA
Genome Projectcalcium ion binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005516
IDA
ISO
Genome Projectcalmodulin binding
GO:0015278
ISO
Genome Projectcalcium-release channel activity
GO:0019899
ISO
Genome Projectenzyme binding
GO:0034236
ISO
Genome Projectprotein kinase A catalytic subunit binding
GO:0034237
ISO
Genome Projectprotein kinase A regulatory subunit binding
GO:0042802
ISO
Genome Projectidentical protein binding
GO:0043924
ISO
Genome Projectsuramin binding
GO:0048763
ISO
Genome Projectcalcium-induced calcium release activity
GO:0097159
IPI
Genome Projectorganic cyclic compound binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005790
IDA
Genome Projectsmooth endoplasmic reticulum
GO:0016020
IDA
ISO
IEA
Genome Projectmembrane
GO:0016021
IC, IEA
Genome Projectintegral component of membrane
GO:0016529
IDA
ISO
Genome Projectsarcoplasmic reticulum
GO:0030018
IDA
Genome ProjectZ disc
GO:0033017
IDA
Genome Projectsarcoplasmic reticulum membrane
GO:0034704
ISO
Genome Projectcalcium channel complex
GO:0043234
ISO
Genome Projectprotein complex
GO:0070062
ISO
Genome Projectextracellular exosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000699RIH (RyR and IP3R Homology) domain
IPR001870B30.2/SPRY domain
IPR002048EF-hand domain
IPR003032Ryanodine receptor Ryr
IPR003877SPRY domain
IPR005821Ion transport domain
IPR009460Ryanodine Receptor TM 4-6
IPR011992EF-hand domain pair
IPR013320Concanavalin A-like lectin/glucanase domain
IPR013333Ryanodine receptor
IPR013662RyR/IP3R Homology associated domain
IPR014821Inositol 1,4,5-trisphosphate/ryanodine receptor
IPR015925Ryanodine receptor-related
IPR016093MIR motif

No MapMan annotations defined for this gene.