Gene: ENSMUSG00000021253 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000021253
Transcript Identifier
ENSMUST00000003687
Gene Type
Coding gene
Location
12 : 86057780-86077932 : negative

Family Information

Homologous gene family
HOM03P019048
(4 genes in 2 species)
specific family
Orthologous gene family
ORTHO03P067390
(2 genes in 2 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
transforming growth factor, beta 3

Identifiers

Type Value
UniprotQ91YU7
MGI98727

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000187
IEA
Genome Projectactivation of MAPK activity
GO:0001666
ISS, ISO
IEA
Genome Projectresponse to hypoxia
GO:0001701
IMP
Genome Projectin utero embryonic development
GO:0007179
ISS, ISO, IBA
IEA
Genome Projecttransforming growth factor beta receptor signaling pathway
GO:0007184
IEA
Genome ProjectSMAD protein import into nucleus
GO:0007435
ISS
IEA
Genome Projectsalivary gland morphogenesis
GO:0007565
IEA
Genome Projectfemale pregnancy
GO:0007568
IEA
Genome Projectaging
GO:0008156
ISS, ISO
IEA
Genome Projectnegative regulation of DNA replication
GO:0008285
IDA
IEA
Genome Projectnegative regulation of cell proliferation
GO:0009887
IMP
Genome Projectorgan morphogenesis
GO:0010718
ISS, ISO
Genome Projectpositive regulation of epithelial to mesenchymal transition
GO:0010936
ISS, ISO
IEA
Genome Projectnegative regulation of macrophage cytokine production
GO:0016049
IEA
Genome Projectcell growth
GO:0030501
ISS
IEA
Genome Projectpositive regulation of bone mineralization
GO:0030512
IEA
Genome Projectnegative regulation of transforming growth factor beta receptor signaling pathway
GO:0030879
IDA
Genome Projectmammary gland development
GO:0032570
ISS, ISO
IEA
Genome Projectresponse to progesterone
GO:0032967
ISS, ISO
IEA
Genome Projectpositive regulation of collagen biosynthetic process
GO:0034616
IEA
Genome Projectresponse to laminar fluid shear stress
GO:0040007
IEA
Genome Projectgrowth
GO:0042060
IEA
Genome Projectwound healing
GO:0043065
IMP
IEA
Genome Projectpositive regulation of apoptotic process
GO:0043408
IBA
Genome Projectregulation of MAPK cascade
GO:0043524
IMP
Genome Projectnegative regulation of neuron apoptotic process
GO:0043627
IEA
Genome Projectresponse to estrogen
GO:0043932
ISS
IEA
Genome Projectossification involved in bone remodeling
GO:0045216
ISS, ISO
IEA
Genome Projectcell-cell junction organization
GO:0045740
ISS, ISO
IEA
Genome Projectpositive regulation of DNA replication
GO:0045893
ISS, ISO
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045944
IGI
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0048468
IBA
Genome Projectcell development
GO:0048565
IEA
Genome Projectdigestive tract development
GO:0048702
IEA
Genome Projectembryonic neurocranium morphogenesis
GO:0048839
IEA
Genome Projectinner ear development
GO:0050714
ISO
IEA
Genome Projectpositive regulation of protein secretion
GO:0051491
IMP
Genome Projectpositive regulation of filopodium assembly
GO:0060325
ISS, ISO
IEA
Genome Projectface morphogenesis
GO:0060364
IEA
Genome Projectfrontal suture morphogenesis
GO:0060395
IBA
Genome ProjectSMAD protein signal transduction
GO:0070483
ISS, ISO
IEA
Genome Projectdetection of hypoxia
GO:0071363
IDA
Genome Projectcellular response to growth factor stimulus

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005114
ISS, ISO, IBA
IEA
Genome Projecttype II transforming growth factor beta receptor binding
GO:0005125
IBA
Genome Projectcytokine activity
GO:0005160
IEA
Genome Projecttransforming growth factor beta receptor binding
GO:0008083
IEA
Genome Projectgrowth factor activity
GO:0034713
ISS, ISO
IEA
Genome Projecttype I transforming growth factor beta receptor binding
GO:0034714
ISS, ISO
IEA
Genome Projecttype III transforming growth factor beta receptor binding
GO:0042802
ISS, ISO
IEA
Genome Projectidentical protein binding
GO:0046982
IEA
Genome Projectprotein heterodimerization activity
GO:0050431
ISS, ISO
IEA
Genome Projecttransforming growth factor beta binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
IEA
Genome Projectextracellular region
GO:0005578
IDA
Genome Projectproteinaceous extracellular matrix
GO:0005615
IBA
IEA
Genome Projectextracellular space
GO:0005634
IEA
Genome Projectnucleus
GO:0005737
IEA
Genome Projectcytoplasm
GO:0009986
IEA
Genome Projectcell surface
GO:0030141
IEA
Genome Projectsecretory granule
GO:0030315
IEA
Genome ProjectT-tubule
GO:0031012
ISO
IEA
Genome Projectextracellular matrix
GO:0043025
IEA
Genome Projectneuronal cell body

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001111Transforming growth factor-beta, N-terminal
IPR001839Transforming growth factor-beta, C-terminal
IPR015615Transforming growth factor-beta-related
IPR015618Transforming growth factor beta-3
IPR016319Transforming growth factor-beta
IPR017948Transforming growth factor beta, conserved site
IPR029034Cystine-knot cytokine

No MapMan annotations defined for this gene.