Gene: ENSMUSG00000021109 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000021109
Transcript Identifier
ENSMUST00000021530
Gene Type
Coding gene
Location
12 : 73908290-73945703 : positive

Family Information

Homologous gene family
HOM03P004831
(19 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P024249
(4 genes in 2 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
hypoxia inducible factor 1, alpha subunit

Identifiers

Type Value
UniprotQ61221
MGI106918

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001525
IMP
Genome Projectangiogenesis
GO:0001568
IMP
Genome Projectblood vessel development
GO:0001666
IDA, IMP, IGI
ISS, ISO
IEA
Genome Projectresponse to hypoxia
GO:0001755
IMP
Genome Projectneural crest cell migration
GO:0001837
IMP
Genome Projectepithelial to mesenchymal transition
GO:0001892
IMP, IGI
Genome Projectembryonic placenta development
GO:0001922
IMP
Genome ProjectB-1 B cell homeostasis
GO:0001944
IGI
Genome Projectvasculature development
GO:0001947
IMP
Genome Projectheart looping
GO:0002052
IGI
Genome Projectpositive regulation of neuroblast proliferation
GO:0002248
IMP
Genome Projectconnective tissue replacement involved in inflammatory response wound healing
GO:0003151
IMP
Genome Projectoutflow tract morphogenesis
GO:0003208
IMP
Genome Projectcardiac ventricle morphogenesis
GO:0006089
IMP
Genome Projectlactate metabolic process
GO:0006110
IGI
Genome Projectregulation of glycolytic process
GO:0006351
IEA
Genome Projecttranscription, DNA-templated
GO:0006355
IDA
ISS, ISO
IEA
Genome Projectregulation of transcription, DNA-templated
GO:0006366
IDA
Genome Projecttranscription from RNA polymerase II promoter
GO:0006879
IMP
Genome Projectcellular iron ion homeostasis
GO:0007165
ISO
Genome Projectsignal transduction
GO:0007595
IMP
Genome Projectlactation
GO:0008542
IMP
Genome Projectvisual learning
GO:0010468
IMP
ISO
IEA
Genome Projectregulation of gene expression
GO:0010508
IMP
Genome Projectpositive regulation of autophagy
GO:0010573
ISO
IEA
Genome Projectvascular endothelial growth factor production
GO:0010575
ISS, ISO
IEA
Genome Projectpositive regulation of vascular endothelial growth factor production
GO:0010634
IMP
Genome Projectpositive regulation of epithelial cell migration
GO:0010870
ISO
IEA
Genome Projectpositive regulation of receptor biosynthetic process
GO:0014850
IMP
Genome Projectresponse to muscle activity
GO:0019896
ISS, ISO
IEA
Genome Projectaxon transport of mitochondrion
GO:0021502
IMP
Genome Projectneural fold elevation formation
GO:0021987
IMP
Genome Projectcerebral cortex development
GO:0030154
IMP, IGI
Genome Projectcell differentiation
GO:0030279
IMP
Genome Projectnegative regulation of ossification
GO:0030502
IMP
Genome Projectnegative regulation of bone mineralization
GO:0030949
IMP
Genome Projectpositive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032007
IMP
Genome Projectnegative regulation of TOR signaling
GO:0032364
IMP
ISO
IEA
Genome Projectoxygen homeostasis
GO:0032909
ISO
IEA
Genome Projectregulation of transforming growth factor beta2 production
GO:0032963
IMP
Genome Projectcollagen metabolic process
GO:0035162
IMP
Genome Projectembryonic hemopoiesis
GO:0035774
IMP
Genome Projectpositive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0042127
IMP
Genome Projectregulation of cell proliferation
GO:0042541
IMP
Genome Projecthemoglobin biosynthetic process
GO:0042593
IMP
Genome Projectglucose homeostasis
GO:0043066
IMP
Genome Projectnegative regulation of apoptotic process
GO:0043524
IMP
Genome Projectnegative regulation of neuron apoptotic process
GO:0043619
IMP
ISO
IEA
Genome Projectregulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0045648
IMP
Genome Projectpositive regulation of erythrocyte differentiation
GO:0045893
ISS, ISO
IEA
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045926
IMP
Genome Projectnegative regulation of growth
GO:0045944
IDA, IMP, IGI
ISO
IEA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046716
IMP
Genome Projectmuscle cell cellular homeostasis
GO:0046886
ISO
IEA
Genome Projectpositive regulation of hormone biosynthetic process
GO:0048514
IMP
Genome Projectblood vessel morphogenesis
GO:0048546
IMP
Genome Projectdigestive tract morphogenesis
GO:0050790
IMP
Genome Projectregulation of catalytic activity
GO:0051216
IMP
Genome Projectcartilage development
GO:0051541
IMP
Genome Projectelastin metabolic process
GO:0060574
IMP
Genome Projectintestinal epithelial cell maturation
GO:0061030
IMP
Genome Projectepithelial cell differentiation involved in mammary gland alveolus development
GO:0061298
IMP
Genome Projectretina vasculature development in camera-type eye
GO:0061419
ISS, ISO
IEA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070243
IGI
Genome Projectregulation of thymocyte apoptotic process
GO:0070244
IMP
Genome Projectnegative regulation of thymocyte apoptotic process
GO:0071347
IEA
Genome Projectcellular response to interleukin-1
GO:0071456
IGI
ISS, ISO
IEA
Genome Projectcellular response to hypoxia
GO:0071542
IMP, IGI
Genome Projectdopaminergic neuron differentiation
GO:0097411
IDA
Genome Projecthypoxia-inducible factor-1alpha signaling pathway
GO:1903377
ISO
IEA
Genome Projectnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903599
IMP
Genome Projectpositive regulation of mitophagy
GO:1903715
IMP
Genome Projectregulation of aerobic respiration
GO:2000378
IMP
Genome Projectnegative regulation of reactive oxygen species metabolic process
GO:2001054
IMP
Genome Projectnegative regulation of mesenchymal cell apoptotic process

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000981
IDA
Genome ProjectRNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0000989
ISO
IEA
Genome Projecttranscription factor activity, transcription factor binding
GO:0001076
IPI
Genome Projecttranscription factor activity, RNA polymerase II transcription factor binding
GO:0001077
IDA
Genome Projecttranscriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003677
IDA, IGI
IEA
Genome ProjectDNA binding
GO:0003700
IDA
ISO
IEA
Genome Projecttranscription factor activity, sequence-specific DNA binding
GO:0003705
ISO
IEA
Genome Projecttranscription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008134
ISO
IEA
Genome Projecttranscription factor binding
GO:0019899
ISO
IEA
Genome Projectenzyme binding
GO:0019901
ISO
IEA
Genome Projectprotein kinase binding
GO:0031625
ISO
IEA
Genome Projectubiquitin protein ligase binding
GO:0035035
ISS, ISO
IEA
Genome Projecthistone acetyltransferase binding
GO:0035257
ISO
IEA
Genome Projectnuclear hormone receptor binding
GO:0042826
IPI
Genome Projecthistone deacetylase binding
GO:0043565
IDA
ISO
IEA
Genome Projectsequence-specific DNA binding
GO:0046982
ISS, ISO
IEA
Genome Projectprotein heterodimerization activity
GO:0046983
IEA
Genome Projectprotein dimerization activity
GO:0051879
ISO
IEA
Genome ProjectHsp90 protein binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
ISS, ISO
IEA
Genome Projectnucleus
GO:0005667
ISO
IEA
Genome Projecttranscription factor complex
GO:0005730
ISO
IEA
Genome Projectnucleolus
GO:0005737
ISO
IEA
Genome Projectcytoplasm
GO:0005829
ISS, ISO
IEA
Genome Projectcytosol
GO:0016607
IDA
IEA
Genome Projectnuclear speck
GO:0031514
IDA
Genome Projectmotile cilium
GO:0090575
ISO
IEA
Genome ProjectRNA polymerase II transcription factor complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000014PAS domain
IPR001321Hypoxia-inducible factor-1 alpha
IPR001610PAC motif
IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
IPR013655PAS fold-3
IPR013767PAS fold
IPR014887HIF-1 alpha, transactivation domain, C-terminal
IPR021537Hypoxia-inducible factor, alpha subunit

No MapMan annotations defined for this gene.