Gene: ENSMUSG00000021048 (Mus musculus)

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Gene Identifier
ENSMUSG00000021048
Transcript Identifier
ENSMUST00000021443
Gene Type
Coding gene
Location
12 : 76255504-76317696 : positive

Family Information

Homologous gene family
HOM03P001580
(48 genes in 38 species)
specific family
Orthologous gene family
ORTHO03P000944
(42 genes in 38 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
methylenetetrahydrofolate dehydrogenase (NADP dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase

Identifiers

Type Value
UniprotQ922D8
MGI1342005

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000105
IEA
Genome Projecthistidine biosynthetic process
GO:0001780
IMP
Genome Projectneutrophil homeostasis
GO:0001843
IMP
Genome Projectneural tube closure
GO:0006164
IMP
IEA
Genome Projectpurine nucleotide biosynthetic process
GO:0006555
IMP
Genome Projectmethionine metabolic process
GO:0006730
ISO, IBA
IEA
Genome Projectone-carbon metabolic process
GO:0007507
IMP
Genome Projectheart development
GO:0008152
IEA
Genome Projectmetabolic process
GO:0008652
IEA
Genome Projectcellular amino acid biosynthetic process
GO:0009069
IMP
Genome Projectserine family amino acid metabolic process
GO:0009070
ISO
Genome Projectserine family amino acid biosynthetic process
GO:0009086
ISO
IEA
Genome Projectmethionine biosynthetic process
GO:0009257
IMP
Genome Project10-formyltetrahydrofolate biosynthetic process
GO:0009396
IEA
Genome Projectfolic acid-containing compound biosynthetic process
GO:0019346
IMP
Genome Projecttranssulfuration
GO:0035999
IMP
IEA
Genome Projecttetrahydrofolate interconversion
GO:0055114
IEA
Genome Projectoxidation-reduction process
GO:0061053
IMP
Genome Projectsomite development

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0003824
IEA
Genome Projectcatalytic activity
GO:0004329
IMP
IBA
IEA
Genome Projectformate-tetrahydrofolate ligase activity
GO:0004477
IBA
IEA
Genome Projectmethenyltetrahydrofolate cyclohydrolase activity
GO:0004487
IDA
Genome Projectmethylenetetrahydrofolate dehydrogenase (NAD+) activity
GO:0004488
IBA
IEA
Genome Projectmethylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0005524
IEA
Genome ProjectATP binding
GO:0016491
IEA
Genome Projectoxidoreductase activity
GO:0016787
IEA
Genome Projecthydrolase activity
GO:0016874
IEA
Genome Projectligase activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
IEA
Genome Projectcytoplasm
GO:0005739
IDA
Genome Projectmitochondrion
GO:0005829
IBA
Genome Projectcytosol
GO:0016020
ISO
IEA
Genome Projectmembrane
GO:0070062
ISO
IEA
Genome Projectextracellular exosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000559Formate-tetrahydrofolate ligase, FTHFS
IPR000672Tetrahydrofolate dehydrogenase/cyclohydrolase
IPR016040NAD(P)-binding domain
IPR020628Formate-tetrahydrofolate ligase, FTHFS, conserved site
IPR020630Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
IPR020631Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
IPR020867Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site
IPR027417P-loop containing nucleoside triphosphate hydrolase

No MapMan annotations defined for this gene.