Gene: ENSMUSG00000020716 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000020716
Transcript Identifier
ENSMUST00000071325
Gene Type
Coding gene
Location
11 : 79340000-79578396 : positive

Family Information

Homologous gene family
HOM03P013079
(6 genes in 5 species)
specific family

Descriptions

gene_descr
neurofibromatosis 1

Identifiers

Type Value
UniprotQ04690
MGI97306

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000165
IMP
Genome ProjectMAPK cascade
GO:0001649
IMP
Genome Projectosteoblast differentiation
GO:0001656
IMP
Genome Projectmetanephros development
GO:0001666
IMP
Genome Projectresponse to hypoxia
GO:0001889
IMP
Genome Projectliver development
GO:0001937
IMP
ISO
IEA
Genome Projectnegative regulation of endothelial cell proliferation
GO:0001938
IGI
Genome Projectpositive regulation of endothelial cell proliferation
GO:0001952
IMP
Genome Projectregulation of cell-matrix adhesion
GO:0001953
IGI
Genome Projectnegative regulation of cell-matrix adhesion
GO:0006469
IMP, IGI
Genome Projectnegative regulation of protein kinase activity
GO:0007154
IMP
Genome Projectcell communication
GO:0007165
IEA
Genome Projectsignal transduction
GO:0007265
IMP, IGI
Genome ProjectRas protein signal transduction
GO:0007406
IMP
Genome Projectnegative regulation of neuroblast proliferation
GO:0007420
IMP
Genome Projectbrain development
GO:0007422
IMP
Genome Projectperipheral nervous system development
GO:0007507
IMP
Genome Projectheart development
GO:0007519
IMP
Genome Projectskeletal muscle tissue development
GO:0008285
IMP, IGI
Genome Projectnegative regulation of cell proliferation
GO:0008542
IMP, IGI
Genome Projectvisual learning
GO:0008625
IGI
Genome Projectextrinsic apoptotic signaling pathway via death domain receptors
GO:0010468
IGI
Genome Projectregulation of gene expression
GO:0014044
IMP
Genome ProjectSchwann cell development
GO:0014065
IMP
Genome Projectphosphatidylinositol 3-kinase signaling
GO:0016525
IGI
Genome Projectnegative regulation of angiogenesis
GO:0021510
IMP
Genome Projectspinal cord development
GO:0021764
IGI
Genome Projectamygdala development
GO:0021897
IMP
Genome Projectforebrain astrocyte development
GO:0021915
IGI
Genome Projectneural tube development
GO:0021987
IMP
Genome Projectcerebral cortex development
GO:0022011
IMP
Genome Projectmyelination in peripheral nervous system
GO:0030036
IMP, IGI
Genome Projectactin cytoskeleton organization
GO:0030198
IMP
Genome Projectextracellular matrix organization
GO:0030199
IMP
Genome Projectcollagen fibril organization
GO:0030325
IMP
Genome Projectadrenal gland development
GO:0030336
IMP, IGI
ISO
IEA
Genome Projectnegative regulation of cell migration
GO:0032228
IGI
Genome Projectregulation of synaptic transmission, GABAergic
GO:0034605
IDA
Genome Projectcellular response to heat
GO:0035021
IGI
Genome Projectnegative regulation of Rac protein signal transduction
GO:0042060
IMP
Genome Projectwound healing
GO:0042127
IGI
Genome Projectregulation of cell proliferation
GO:0042992
IMP
Genome Projectnegative regulation of transcription factor import into nucleus
GO:0043065
IMP, IGI
Genome Projectpositive regulation of apoptotic process
GO:0043087
ISO
IEA
Genome Projectregulation of GTPase activity
GO:0043407
IMP, IGI
Genome Projectnegative regulation of MAP kinase activity
GO:0043408
IGI
Genome Projectregulation of MAPK cascade
GO:0043409
IMP
ISO
Genome Projectnegative regulation of MAPK cascade
GO:0043473
IMP, IGI
Genome Projectpigmentation
GO:0043525
IMP, IGI
Genome Projectpositive regulation of neuron apoptotic process
GO:0043535
ISO
IEA
Genome Projectregulation of blood vessel endothelial cell migration
GO:0043547
IMP
ISO
IEA
Genome Projectpositive regulation of GTPase activity
GO:0045124
IMP
Genome Projectregulation of bone resorption
GO:0045671
IGI
Genome Projectnegative regulation of osteoclast differentiation
GO:0045685
IMP
Genome Projectregulation of glial cell differentiation
GO:0045762
IMP
Genome Projectpositive regulation of adenylate cyclase activity
GO:0045765
IMP
ISO
IEA
Genome Projectregulation of angiogenesis
GO:0046580
IMP, IGI
Genome Projectnegative regulation of Ras protein signal transduction
GO:0046929
IMP, IGI
Genome Projectnegative regulation of neurotransmitter secretion
GO:0048147
IMP
Genome Projectnegative regulation of fibroblast proliferation
GO:0048169
IMP, IGI
Genome Projectregulation of long-term neuronal synaptic plasticity
GO:0048485
IMP
Genome Projectsympathetic nervous system development
GO:0048593
IMP
Genome Projectcamera-type eye morphogenesis
GO:0048712
IMP
Genome Projectnegative regulation of astrocyte differentiation
GO:0048715
IMP
Genome Projectnegative regulation of oligodendrocyte differentiation
GO:0048745
IMP
Genome Projectsmooth muscle tissue development
GO:0048844
IMP
Genome Projectartery morphogenesis
GO:0048853
IMP
Genome Projectforebrain morphogenesis
GO:0050890
ISO
IEA
Genome Projectcognition
GO:0061534
IGI
Genome Projectgamma-aminobutyric acid secretion, neurotransmission
GO:0061535
IGI
Genome Projectglutamate secretion, neurotransmission
GO:0098597
IGI
Genome Projectobservational learning
GO:1900271
IGI
Genome Projectregulation of long-term synaptic potentiation
GO:1902043
IMP
Genome Projectpositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001241
IMP
Genome Projectpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005096
IMP, IGI
ISO
IEA
Genome ProjectGTPase activator activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0008017
ISO
Genome Projectmicrotubule binding
GO:0008289
IEA
Genome Projectlipid binding
GO:0008429
ISS, ISO
IEA
Genome Projectphosphatidylethanolamine binding
GO:0031210
ISS, ISO
IEA
Genome Projectphosphatidylcholine binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IEA
Genome Projectnucleus
GO:0005730
IEA
Genome Projectnucleolus
GO:0005737
IDA
Genome Projectcytoplasm
GO:0016020
ISO
IEA
Genome Projectmembrane
GO:0030424
ISO
IEA
Genome Projectaxon
GO:0030425
ISO
IEA
Genome Projectdendrite
GO:0031235
IBA
Genome Projectintrinsic component of the cytoplasmic side of the plasma membrane

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001251CRAL-TRIO lipid binding domain
IPR001936Ras GTPase-activating protein
IPR008936Rho GTPase activation protein
IPR011989Armadillo-like helical
IPR016024Armadillo-type fold
IPR023152Ras GTPase-activating protein, conserved site
IPR028553Neurofibromin

No MapMan annotations defined for this gene.