Gene: ENSMUSG00000020227 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000020227
Transcript Identifier
ENSMUST00000020448
Gene Type
Coding gene
Location
10 : 120142715-120201459 : negative

Family Information

Homologous gene family
HOM03P000002
(4173 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P066996
(2 genes in 2 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
interleukin-1 receptor-associated kinase 3

Identifiers

Type Value
UniprotQ8K4B2
UniprotQ0VB14
MGI1921164

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0002224
IBA
Genome Projecttoll-like receptor signaling pathway
GO:0006468
IDA
ISO
IEA
Genome Projectprotein phosphorylation
GO:0006915
RCA
Genome Projectapoptotic process
GO:0007165
IEA
Genome Projectsignal transduction
GO:0016310
IEA
Genome Projectphosphorylation
GO:0032088
ISO
IEA
Genome Projectnegative regulation of NF-kappaB transcription factor activity
GO:0032695
IMP
ISO
Genome Projectnegative regulation of interleukin-12 production
GO:0032715
IMP
ISO
Genome Projectnegative regulation of interleukin-6 production
GO:0032720
IMP
ISO
IEA
Genome Projectnegative regulation of tumor necrosis factor production
GO:0035556
IBA
Genome Projectintracellular signal transduction
GO:0042177
IMP
ISO
IEA
Genome Projectnegative regulation of protein catabolic process
GO:0042981
RCA
Genome Projectregulation of apoptotic process
GO:0043242
ISO
IEA
Genome Projectnegative regulation of protein complex disassembly
GO:0043407
IMP
ISO
IEA
Genome Projectnegative regulation of MAP kinase activity
GO:0046777
IDA
Genome Projectprotein autophosphorylation
GO:0051092
IDA
ISO
IEA
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0070498
IDA
ISO
IEA
Genome Projectinterleukin-1-mediated signaling pathway
GO:0070555
ISO
IEA
Genome Projectresponse to interleukin-1
GO:0001960
IC
Genome Projectnegative regulation of cytokine-mediated signaling pathway
GO:0009615
IC
Genome Projectresponse to virus
GO:0010933
IMP
Genome Projectpositive regulation of macrophage tolerance induction
GO:0010936
IMP
Genome Projectnegative regulation of macrophage cytokine production
GO:0019221
IDA
Genome Projectcytokine-mediated signaling pathway
GO:0032494
IMP
Genome Projectresponse to peptidoglycan
GO:0032496
IMP
Genome Projectresponse to lipopolysaccharide
GO:0034122
IMP
Genome Projectnegative regulation of toll-like receptor signaling pathway
GO:0043244
IDA
Genome Projectregulation of protein complex disassembly
GO:0043330
IMP
Genome Projectresponse to exogenous dsRNA
GO:0045824
IMP
Genome Projectnegative regulation of innate immune response

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000287
IDA
ISO
IEA
Genome Projectmagnesium ion binding
GO:0004672
IDA
IEA
Genome Projectprotein kinase activity
GO:0004674
IDA
ISO
IEA
Genome Projectprotein serine/threonine kinase activity
GO:0005524
IDA
ISO
IEA
Genome ProjectATP binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0042803
ISO
IEA
Genome Projectprotein homodimerization activity
GO:0046982
ISO
IEA
Genome Projectprotein heterodimerization activity
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0016740
IEA
Genome Projecttransferase activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
ISO
IEA
Genome Projectnucleus
GO:0005737
IDA
ISO
IEA
Genome Projectcytoplasm
GO:0005886
IBA
Genome Projectplasma membrane

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000488Death domain
IPR000719Protein kinase domain
IPR011009Protein kinase-like domain
IPR011029Death-like domain

No MapMan annotations defined for this gene.