Gene: ENSMUSG00000020122 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000020122
Transcript Identifier
ENSMUST00000020329
Gene Type
Coding gene
Location
11 : 16752483-16911855 : positive

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P009161
(9 genes in 4 species)
specific family

Descriptions

gene_descr
epidermal growth factor receptor

Identifiers

Type Value
UniprotQ01279
MGI95294

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000902
IGI
Genome Projectcell morphogenesis
GO:0001892
IMP
Genome Projectembryonic placenta development
GO:0001934
ISS, ISO
IEA
Genome Projectpositive regulation of protein phosphorylation
GO:0001942
IMP
Genome Projecthair follicle development
GO:0006468
IEA
Genome Projectprotein phosphorylation
GO:0007165
IDA
ISO
IEA
Genome Projectsignal transduction
GO:0007166
ISO
IEA
Genome Projectcell surface receptor signaling pathway
GO:0007169
IEA
Genome Projecttransmembrane receptor protein tyrosine kinase signaling pathway
GO:0007173
IDA, IMP, IGI
ISO
IEA
Genome Projectepidermal growth factor receptor signaling pathway
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0007435
IMP
Genome Projectsalivary gland morphogenesis
GO:0007611
IEA
Genome Projectlearning or memory
GO:0008283
ISO
IEA
Genome Projectcell proliferation
GO:0008284
IDA, IGI
ISO
IEA
Genome Projectpositive regulation of cell proliferation
GO:0008544
IMP
Genome Projectepidermis development
GO:0016310
IEA
Genome Projectphosphorylation
GO:0016337
ISO
IEA
Genome Projectsingle organismal cell-cell adhesion
GO:0018108
ISO
Genome Projectpeptidyl-tyrosine phosphorylation
GO:0021795
IMP
Genome Projectcerebral cortex cell migration
GO:0023014
IEA
Genome Projectsignal transduction by protein phosphorylation
GO:0030335
ISO
IEA
Genome Projectpositive regulation of cell migration
GO:0031659
ISO
IEA
Genome Projectpositive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
GO:0035413
ISO
IEA
Genome Projectpositive regulation of catenin import into nucleus
GO:0042127
IGI
Genome Projectregulation of cell proliferation
GO:0042177
ISO
IEA
Genome Projectnegative regulation of protein catabolic process
GO:0042327
ISO
IEA
Genome Projectpositive regulation of phosphorylation
GO:0043066
ISO
IEA
Genome Projectnegative regulation of apoptotic process
GO:0043406
ISO
IEA
Genome Projectpositive regulation of MAP kinase activity
GO:0045429
ISO
IEA
Genome Projectpositive regulation of nitric oxide biosynthetic process
GO:0045739
ISO
IEA
Genome Projectpositive regulation of DNA repair
GO:0045740
ISO
IEA
Genome Projectpositive regulation of DNA replication
GO:0045944
ISS, ISO
IEA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046777
IDA
ISO
IEA
Genome Projectprotein autophosphorylation
GO:0048146
IMP
Genome Projectpositive regulation of fibroblast proliferation
GO:0048546
IMP
Genome Projectdigestive tract morphogenesis
GO:0050679
IMP
ISO
IEA
Genome Projectpositive regulation of epithelial cell proliferation
GO:0050730
IMP
ISO
IEA
Genome Projectregulation of peptidyl-tyrosine phosphorylation
GO:0050999
ISO
IEA
Genome Projectregulation of nitric-oxide synthase activity
GO:0051897
ISO
IEA
Genome Projectpositive regulation of protein kinase B signaling
GO:0060571
IMP
Genome Projectmorphogenesis of an epithelial fold
GO:0070141
ISO
IEA
Genome Projectresponse to UV-A
GO:0070374
ISS, ISO
IEA
Genome Projectpositive regulation of ERK1 and ERK2 cascade
GO:0071230
IDA
Genome Projectcellular response to amino acid stimulus
GO:0071364
IEA
Genome Projectcellular response to epidermal growth factor stimulus
GO:0071392
ISS, ISO
IEA
Genome Projectcellular response to estradiol stimulus

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0003682
ISS, ISO
IEA
Genome Projectchromatin binding
GO:0004672
IEA
Genome Projectprotein kinase activity
GO:0004713
ISS, ISO
IEA
Genome Projectprotein tyrosine kinase activity
GO:0004714
IEA
Genome Projecttransmembrane receptor protein tyrosine kinase activity
GO:0004716
IEA
Genome Projectreceptor signaling protein tyrosine kinase activity
GO:0004871
IDA
Genome Projectsignal transducer activity
GO:0004888
ISO
IEA
Genome Projecttransmembrane signaling receptor activity
GO:0005006
IDA
ISO
IEA
Genome Projectepidermal growth factor-activated receptor activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
IDA
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0019899
ISO
IEA
Genome Projectenzyme binding
GO:0019903
ISO
IEA
Genome Projectprotein phosphatase binding
GO:0030235
ISO
IEA
Genome Projectnitric-oxide synthase regulator activity
GO:0031625
ISO
IEA
Genome Projectubiquitin protein ligase binding
GO:0042802
ISO
IEA
Genome Projectidentical protein binding
GO:0046982
ISO
IEA
Genome Projectprotein heterodimerization activity
GO:0051015
ISO
IEA
Genome Projectactin filament binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000139
IEA
Genome ProjectGolgi membrane
GO:0005622
IDA
Genome Projectintracellular
GO:0005634
IDA
ISO
IEA
Genome Projectnucleus
GO:0005737
ISO
IEA
Genome Projectcytoplasm
GO:0005768
ISS, ISO
IEA
Genome Projectendosome
GO:0005783
IEA
Genome Projectendoplasmic reticulum
GO:0005789
IEA
Genome Projectendoplasmic reticulum membrane
GO:0005794
IEA
Genome ProjectGolgi apparatus
GO:0005886
IDA
ISO
IEA
Genome Projectplasma membrane
GO:0005925
ISO
IEA
Genome Projectfocal adhesion
GO:0009986
IDA
ISO
Genome Projectcell surface
GO:0010008
ISO
IEA
Genome Projectendosome membrane
GO:0016020
ISO
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0016323
IDA
ISO
IEA
Genome Projectbasolateral plasma membrane
GO:0030139
IDA
Genome Projectendocytic vesicle
GO:0031901
ISO
IEA
Genome Projectearly endosome membrane
GO:0031965
IEA
Genome Projectnuclear membrane
GO:0043235
ISO
IEA
Genome Projectreceptor complex
GO:0045121
ISO
IEA
Genome Projectmembrane raft
GO:0048471
IDA
Genome Projectperinuclear region of cytoplasm
GO:0097489
ISO
IEA
Genome Projectmultivesicular body, internal vesicle lumen

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000494Receptor L-domain
IPR000719Protein kinase domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR006211Furin-like cysteine-rich domain
IPR006212Furin-like repeat
IPR008266Tyrosine-protein kinase, active site
IPR009030Growth factor receptor cysteine-rich domain
IPR011009Protein kinase-like domain
IPR016245Tyrosine protein kinase, EGF/ERB/XmrK receptor
IPR017441Protein kinase, ATP binding site
IPR020635Tyrosine-protein kinase, catalytic domain

No MapMan annotations defined for this gene.