Gene: ENSMUSG00000020063 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000020063
Transcript Identifier
ENSMUST00000020257
Gene Type
Coding gene
Location
10 : 63320636-63338970 : negative

Family Information

Homologous gene family
HOM03P000910
(65 genes in 31 species)
specific family
Orthologous gene family
ORTHO03P006811
(12 genes in 11 species)
specific family

Descriptions

gene_descr
sirtuin 1

Identifiers

Type Value
UniprotQ923E4
UniprotQ53Z05
MGI2135607

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000012
ISS, ISO
IEA
Genome Projectsingle strand break repair
GO:0000122
IDA, IMP
ISS, ISO
IEA
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0000183
ISO
IEA
Genome Projectchromatin silencing at rDNA
GO:0000720
IMP
ISO
IEA
Genome Projectpyrimidine dimer repair by nucleotide-excision repair
GO:0001525
ISS, ISO
IEA
Genome Projectangiogenesis
GO:0001542
IMP
Genome Projectovulation from ovarian follicle
GO:0002821
ISS, ISO
IEA
Genome Projectpositive regulation of adaptive immune response
GO:0006325
ISO
IEA
Genome Projectchromatin organization
GO:0006343
ISO
IEA
Genome Projectestablishment of chromatin silencing
GO:0006344
ISO
IEA
Genome Projectmaintenance of chromatin silencing
GO:0006476
IDA, IMP
ISO
IEA
Genome Projectprotein deacetylation
GO:0006974
ISO
IEA
Genome Projectcellular response to DNA damage stimulus
GO:0006979
ISO
IEA
Genome Projectresponse to oxidative stress
GO:0007283
IMP
Genome Projectspermatogenesis
GO:0007346
ISS, ISO
IEA
Genome Projectregulation of mitotic cell cycle
GO:0008284
ISS, ISO
IEA
Genome Projectpositive regulation of cell proliferation
GO:0010629
ISO
IEA
Genome Projectnegative regulation of gene expression
GO:0016239
IDA
ISO
IEA
Genome Projectpositive regulation of macroautophagy
GO:0016567
ISS, ISO
IEA
Genome Projectprotein ubiquitination
GO:0016575
IDA, IGI
ISS, ISO
IEA
Genome Projecthistone deacetylation
GO:0018394
ISO
IEA
Genome Projectpeptidyl-lysine acetylation
GO:0030308
ISO
IEA
Genome Projectnegative regulation of cell growth
GO:0031648
IDA
ISO
Genome Projectprotein destabilization
GO:0031937
ISO
IEA
Genome Projectpositive regulation of chromatin silencing
GO:0032007
IMP
ISO
IEA
Genome Projectnegative regulation of TOR signaling
GO:0032071
ISS, ISO
IEA
Genome Projectregulation of endodeoxyribonuclease activity
GO:0032088
ISS, ISO
IEA
Genome Projectnegative regulation of NF-kappaB transcription factor activity
GO:0032922
IMP
ISO
Genome Projectcircadian regulation of gene expression
GO:0033158
ISO
IEA
Genome Projectregulation of protein import into nucleus, translocation
GO:0034983
ISO
IEA
Genome Projectpeptidyl-lysine deacetylation
GO:0042127
ISO
IEA
Genome Projectregulation of cell proliferation
GO:0042326
IMP
ISO
IEA
Genome Projectnegative regulation of phosphorylation
GO:0042542
ISS, ISO
IEA
Genome Projectresponse to hydrogen peroxide
GO:0042595
IMP
Genome Projectbehavioral response to starvation
GO:0042771
ISS, ISO
IEA
Genome Projectintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043065
ISS, ISO
IEA
Genome Projectpositive regulation of apoptotic process
GO:0043066
ISS, ISO
IEA
Genome Projectnegative regulation of apoptotic process
GO:0043124
ISS, ISO
IEA
Genome Projectnegative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161
ISS, ISO
IEA
Genome Projectproteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043280
ISO
IEA
Genome Projectpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043433
IMP
ISO
IEA
Genome Projectnegative regulation of sequence-specific DNA binding transcription factor activity
GO:0043518
ISO
IEA
Genome Projectnegative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045348
ISO
IEA
Genome Projectpositive regulation of MHC class II biosynthetic process
GO:0045739
ISS, ISO
IEA
Genome Projectpositive regulation of DNA repair
GO:0045892
IDA
ISO
IEA
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045944
IDA
ISS, ISO
IEA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046628
ISS, ISO
IEA
Genome Projectpositive regulation of insulin receptor signaling pathway
GO:0051097
ISO
IEA
Genome Projectnegative regulation of helicase activity
GO:0051574
ISO
IEA
Genome Projectpositive regulation of histone H3-K9 methylation
GO:0051898
IMP
ISO
IEA
Genome Projectnegative regulation of protein kinase B signaling
GO:0060766
ISO
IEA
Genome Projectnegative regulation of androgen receptor signaling pathway
GO:0070301
ISO
IEA
Genome Projectcellular response to hydrogen peroxide
GO:0070914
ISO
IEA
Genome ProjectUV-damage excision repair
GO:0070932
ISO
IEA
Genome Projecthistone H3 deacetylation
GO:0071356
ISS, ISO
IEA
Genome Projectcellular response to tumor necrosis factor
GO:0071441
ISO
IEA
Genome Projectnegative regulation of histone H3-K14 acetylation
GO:0071456
ISS, ISO
IEA
Genome Projectcellular response to hypoxia
GO:0090400
ISO
IEA
Genome Projectstress-induced premature senescence
GO:1901215
IGI
Genome Projectnegative regulation of neuron death
GO:1901984
ISO
IEA
Genome Projectnegative regulation of protein acetylation
GO:1902176
ISO
IEA
Genome Projectnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:2000480
ISS, ISO
IEA
Genome Projectnegative regulation of cAMP-dependent protein kinase activity
GO:2000481
IDA
ISO
IEA
Genome Projectpositive regulation of cAMP-dependent protein kinase activity
GO:2000619
ISO
IEA
Genome Projectnegative regulation of histone H4-K16 acetylation
GO:2000655
ISO
IEA
Genome Projectnegative regulation of cellular response to testosterone stimulus
GO:2000757
ISS, ISO
IEA
Genome Projectnegative regulation of peptidyl-lysine acetylation
GO:2000773
ISS, ISO
IEA
Genome Projectnegative regulation of cellular senescence
GO:2000774
ISS, ISO
IEA
Genome Projectpositive regulation of cellular senescence
GO:0000731
IMP
Genome ProjectDNA synthesis involved in DNA repair
GO:0001678
IMP
Genome Projectcellular glucose homeostasis
GO:0001934
IMP
Genome Projectpositive regulation of protein phosphorylation
GO:0006351
IEA
Genome Projecttranscription, DNA-templated
GO:0006355
IEA
Genome Projectregulation of transcription, DNA-templated
GO:0006364
IEA
Genome ProjectrRNA processing
GO:0006642
IMP
Genome Projecttriglyceride mobilization
GO:0006915
IEA
Genome Projectapoptotic process
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0007517
IEA
Genome Projectmuscle organ development
GO:0007623
IEP
Genome Projectcircadian rhythm
GO:0008630
IDA
Genome Projectintrinsic apoptotic signaling pathway in response to DNA damage
GO:0009267
IMP
Genome Projectcellular response to starvation
GO:0010875
IMP
Genome Projectpositive regulation of cholesterol efflux
GO:0010906
IMP
Genome Projectregulation of glucose metabolic process
GO:0030154
IEA
Genome Projectcell differentiation
GO:0030512
IDA
Genome Projectnegative regulation of transforming growth factor beta receptor signaling pathway
GO:0031393
IMP
Genome Projectnegative regulation of prostaglandin biosynthetic process
GO:0032868
IDA
Genome Projectresponse to insulin
GO:0034391
IDA
Genome Projectregulation of smooth muscle cell apoptotic process
GO:0035356
IMP
Genome Projectcellular triglyceride homeostasis
GO:0035358
IMP
Genome Projectregulation of peroxisome proliferator activated receptor signaling pathway
GO:0042632
IMP
Genome Projectcholesterol homeostasis
GO:0045599
IMP
Genome Projectnegative regulation of fat cell differentiation
GO:0048511
IEA
Genome Projectrhythmic process
GO:0050872
IMP
Genome Projectwhite fat cell differentiation
GO:0055089
IMP
Genome Projectfatty acid homeostasis
GO:0061647
IDA
Genome Projecthistone H3-K9 modification
GO:0070857
IMP
Genome Projectregulation of bile acid biosynthetic process
GO:0071479
IMP
Genome Projectcellular response to ionizing radiation
GO:1902166
IMP
Genome Projectnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:1902237
IMP
Genome Projectpositive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1990619
IDA
Genome Projecthistone H3-K9 deacetylation
GO:2000111
IMP
Genome Projectpositive regulation of macrophage apoptotic process

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0002039
IPI
ISO
IEA
Genome Projectp53 binding
GO:0003714
IMP
ISO
Genome Projecttranscription corepressor activity
GO:0004407
ISO
IEA
Genome Projecthistone deacetylase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0008022
ISO
IEA
Genome Projectprotein C-terminus binding
GO:0008134
ISO
IEA
Genome Projecttranscription factor binding
GO:0017136
IDA
ISO, ISA
IEA
Genome ProjectNAD-dependent histone deacetylase activity
GO:0019213
IMP
ISO
IEA
Genome Projectdeacetylase activity
GO:0019899
IPI
ISO
IEA
Genome Projectenzyme binding
GO:0033558
IDA, IMP
ISO
IEA
Genome Projectprotein deacetylase activity
GO:0034979
IDA
ISO
IEA
Genome ProjectNAD-dependent protein deacetylase activity
GO:0035257
ISO
Genome Projectnuclear hormone receptor binding
GO:0042393
ISO
IEA
Genome Projecthistone binding
GO:0042802
ISO
IEA
Genome Projectidentical protein binding
GO:0043398
ISO
IEA
Genome ProjectHLH domain binding
GO:0043425
ISS, ISO
IEA
Genome ProjectbHLH transcription factor binding
GO:0051019
ISO
IEA
Genome Projectmitogen-activated protein kinase binding
GO:0070403
IEA
Genome ProjectNAD+ binding
GO:1990254
ISO
IEA
Genome Projectkeratin filament binding
GO:0001046
IDA
Genome Projectcore promoter sequence-specific DNA binding
GO:0016787
IEA
Genome Projecthydrolase activity
GO:0019904
IPI
Genome Projectprotein domain specific binding
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0046969
IDA
Genome ProjectNAD-dependent histone deacetylase activity (H3-K9 specific)

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000790
ISO
IEA
Genome Projectnuclear chromatin
GO:0005634
IDA
ISO
IEA
Genome Projectnucleus
GO:0005635
ISO
IEA
Genome Projectnuclear envelope
GO:0005637
ISS, ISO
IEA
Genome Projectnuclear inner membrane
GO:0005654
ISS, ISO
TAS, IEA
Genome Projectnucleoplasm
GO:0005677
ISO
IEA
Genome Projectchromatin silencing complex
GO:0005719
ISS, ISO
IEA
Genome Projectnuclear euchromatin
GO:0005720
IDA
ISO
IEA
Genome Projectnuclear heterochromatin
GO:0005730
IEA
Genome Projectnucleolus
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005739
ISO
IEA
Genome Projectmitochondrion
GO:0016605
ISO
IEA
Genome ProjectPML body
GO:0033553
ISO
IEA
Genome ProjectrDNA heterochromatin
GO:0035098
ISS, ISO
IEA
Genome ProjectESC/E(Z) complex
GO:0000785
IDA
Genome Projectchromatin

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR003000Sirtuin family
IPR026590Sirtuin family, catalytic core domain
IPR026591Sirtuin family, catalytic core small domain
IPR029035DHS-like NAD/FAD-binding domain

No MapMan annotations defined for this gene.