Gene: ENSMUSG00000020053 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000020053
Transcript Identifier
ENSMUST00000062862
Gene Type
Coding gene
Location
10 : 87861371-87915441 : positive

Family Information

Homologous gene family
HOM03P037087
(2 genes in 2 species)
specific family

Descriptions

gene_descr
insulin-like growth factor 1

Identifiers

Type Value
UniprotQ8CAR0
MGI96432

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001775
ISO
IEA
Genome Projectcell activation
GO:0001932
IDA
Genome Projectregulation of protein phosphorylation
GO:0001974
IMP, IGI
Genome Projectblood vessel remodeling
GO:0007399
IMP
Genome Projectnervous system development
GO:0008283
ISO
IEA
Genome Projectcell proliferation
GO:0008284
IGI
ISO
IEA
Genome Projectpositive regulation of cell proliferation
GO:0008285
IMP, IGI
Genome Projectnegative regulation of cell proliferation
GO:0009408
ISO
IEA
Genome Projectresponse to heat
GO:0010001
IMP
Genome Projectglial cell differentiation
GO:0010468
ISO
IEA
Genome Projectregulation of gene expression
GO:0010560
ISO
Genome Projectpositive regulation of glycoprotein biosynthetic process
GO:0010613
ISO
IEA
Genome Projectpositive regulation of cardiac muscle hypertrophy
GO:0014065
ISO
Genome Projectphosphatidylinositol 3-kinase signaling
GO:0014068
IDA
ISO
IEA
Genome Projectpositive regulation of phosphatidylinositol 3-kinase signaling
GO:0014834
ISO
IEA
Genome Projectskeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
GO:0014896
ISO
IEA
Genome Projectmuscle hypertrophy
GO:0014904
ISO
IEA
Genome Projectmyotube cell development
GO:0014911
ISO
IEA
Genome Projectpositive regulation of smooth muscle cell migration
GO:0021940
IDA
Genome Projectpositive regulation of cerebellar granule cell precursor proliferation
GO:0030104
IGI
Genome Projectwater homeostasis
GO:0030166
ISO
IEA
Genome Projectproteoglycan biosynthetic process
GO:0030324
IGI
Genome Projectlung development
GO:0030335
ISO
Genome Projectpositive regulation of cell migration
GO:0030879
IMP
Genome Projectmammary gland development
GO:0031017
IMP
Genome Projectexocrine pancreas development
GO:0032878
IDA
Genome Projectregulation of establishment or maintenance of cell polarity
GO:0033160
ISO
IEA
Genome Projectpositive regulation of protein import into nucleus, translocation
GO:0034392
ISO
IEA
Genome Projectnegative regulation of smooth muscle cell apoptotic process
GO:0035264
IDA
Genome Projectmulticellular organism growth
GO:0035630
ISO
IEA
Genome Projectbone mineralization involved in bone maturation
GO:0040014
IEA
Genome Projectregulation of multicellular organism growth
GO:0042104
ISO
IEA
Genome Projectpositive regulation of activated T cell proliferation
GO:0042523
ISO
IEA
Genome Projectpositive regulation of tyrosine phosphorylation of Stat5 protein
GO:0043066
IDA
ISO
IEA
Genome Projectnegative regulation of apoptotic process
GO:0043388
ISO
IEA
Genome Projectpositive regulation of DNA binding
GO:0043410
ISO
IEA
Genome Projectpositive regulation of MAPK cascade
GO:0043491
ISO
Genome Projectprotein kinase B signaling
GO:0043568
ISO
IEA
Genome Projectpositive regulation of insulin-like growth factor receptor signaling pathway
GO:0045445
ISO
IEA
Genome Projectmyoblast differentiation
GO:0045669
ISO
IEA
Genome Projectpositive regulation of osteoblast differentiation
GO:0045725
ISO
IEA
Genome Projectpositive regulation of glycogen biosynthetic process
GO:0045740
ISO
Genome Projectpositive regulation of DNA replication
GO:0045821
ISO
IEA
Genome Projectpositive regulation of glycolytic process
GO:0045840
ISO
IEA
Genome Projectpositive regulation of mitotic nuclear division
GO:0045893
ISO
IEA
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045944
IDA, IMP, IGI
ISO
IEA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046326
ISO
IEA
Genome Projectpositive regulation of glucose import
GO:0046579
ISO
IEA
Genome Projectpositive regulation of Ras protein signal transduction
GO:0048009
IDA
Genome Projectinsulin-like growth factor receptor signaling pathway
GO:0048015
ISO
IEA
Genome Projectphosphatidylinositol-mediated signaling
GO:0048146
ISO
IEA
Genome Projectpositive regulation of fibroblast proliferation
GO:0048286
IMP, IGI
Genome Projectlung alveolus development
GO:0048468
IMP
Genome Projectcell development
GO:0048661
ISO
IEA
Genome Projectpositive regulation of smooth muscle cell proliferation
GO:0048754
IMP
Genome Projectbranching morphogenesis of an epithelial tube
GO:0048839
IDA
Genome Projectinner ear development
GO:0050650
IDA
Genome Projectchondroitin sulfate proteoglycan biosynthetic process
GO:0050679
ISO
IEA
Genome Projectpositive regulation of epithelial cell proliferation
GO:0050714
ISO
Genome Projectpositive regulation of protein secretion
GO:0050731
ISO
IEA
Genome Projectpositive regulation of peptidyl-tyrosine phosphorylation
GO:0050821
ISO
Genome Projectprotein stabilization
GO:0051246
IGI
Genome Projectregulation of protein metabolic process
GO:0051450
ISO
IEA
Genome Projectmyoblast proliferation
GO:0051897
IDA
Genome Projectpositive regulation of protein kinase B signaling
GO:0060283
ISO
IEA
Genome Projectnegative regulation of oocyte development
GO:0060426
IMP, IGI
Genome Projectlung vasculature development
GO:0060463
IMP, IGI
Genome Projectlung lobe morphogenesis
GO:0060509
IMP
Genome ProjectType I pneumocyte differentiation
GO:0060510
IMP
Genome ProjectType II pneumocyte differentiation
GO:0060527
IMP
Genome Projectprostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060736
IDA, IMP
Genome Projectprostate gland growth
GO:0060740
IMP
Genome Projectprostate gland epithelium morphogenesis
GO:0060741
IMP
Genome Projectprostate gland stromal morphogenesis
GO:0060766
IMP
Genome Projectnegative regulation of androgen receptor signaling pathway
GO:0070371
ISO
Genome ProjectERK1 and ERK2 cascade
GO:0070373
IGI
Genome Projectnegative regulation of ERK1 and ERK2 cascade
GO:0070886
ISO
IEA
Genome Projectpositive regulation of calcineurin-NFAT signaling cascade
GO:0097192
IDA
Genome Projectextrinsic apoptotic signaling pathway in absence of ligand
GO:1904075
ISO
Genome Projectpositive regulation of trophectodermal cell proliferation
GO:2000288
IMP
Genome Projectpositive regulation of myoblast proliferation
GO:2001237
ISO
IEA
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005158
ISO
IEA
Genome Projectinsulin receptor binding
GO:0005159
IPI
ISO
IEA
Genome Projectinsulin-like growth factor receptor binding
GO:0005178
ISO
IEA
Genome Projectintegrin binding
GO:0005179
ISO
IEA
Genome Projecthormone activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0008083
IEA
Genome Projectgrowth factor activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
IEA
Genome Projectextracellular region
GO:0005615
IDA
ISO
IEA
Genome Projectextracellular space
GO:0005622
ISO
IEA
Genome Projectintracellular
GO:0042567
ISO
Genome Projectinsulin-like growth factor ternary complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR016179Insulin-like
IPR022341Insulin-like growth factor I
IPR022350Insulin-like growth factor
IPR022352Insulin family
IPR022353Insulin, conserved site

No MapMan annotations defined for this gene.