Gene: ENSMUSG00000019969 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000019969
Transcript Identifier
ENSMUST00000101225
Gene Type
Coding gene
Location
12 : 83699565-83734071 : positive

Family Information

Homologous gene family
HOM03P001593
(48 genes in 34 species)
specific family
Orthologous gene family
ORTHO03P001201
(40 genes in 33 species)
specific family

Descriptions

gene_descr
presenilin 1

Identifiers

Type Value
UniprotP49769
UniprotQ3UYK2
MGI1202717

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000045
IMP
Genome Projectautophagosome assembly
GO:0000122
IMP
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0000186
IMP
Genome Projectactivation of MAPKK activity
GO:0001568
IMP
Genome Projectblood vessel development
GO:0001708
IGI
Genome Projectcell fate specification
GO:0001756
IMP, IGI
Genome Projectsomitogenesis
GO:0001764
IMP
Genome Projectneuron migration
GO:0001921
IMP
Genome Projectpositive regulation of receptor recycling
GO:0001933
IGI
Genome Projectnegative regulation of protein phosphorylation
GO:0001934
IMP
Genome Projectpositive regulation of protein phosphorylation
GO:0001947
IGI
Genome Projectheart looping
GO:0002244
IGI
Genome Projecthematopoietic progenitor cell differentiation
GO:0002286
IGI
Genome ProjectT cell activation involved in immune response
GO:0002573
IGI
Genome Projectmyeloid leukocyte differentiation
GO:0003407
IEA
Genome Projectneural retina development
GO:0006469
IMP
Genome Projectnegative regulation of protein kinase activity
GO:0006486
IMP
Genome Projectprotein glycosylation
GO:0006508
IEA
Genome Projectproteolysis
GO:0006509
ISS, ISO, IBA
IEA
Genome Projectmembrane protein ectodomain proteolysis
GO:0006816
IBA
Genome Projectcalcium ion transport
GO:0006839
IMP
Genome Projectmitochondrial transport
GO:0006874
IMP
Genome Projectcellular calcium ion homeostasis
GO:0006914
IMP
Genome Projectautophagy
GO:0006915
IEA
Genome Projectapoptotic process
GO:0006974
IMP
Genome Projectcellular response to DNA damage stimulus
GO:0006979
IMP, IGI
Genome Projectresponse to oxidative stress
GO:0007155
IEA
Genome Projectcell adhesion
GO:0007175
IMP
Genome Projectnegative regulation of epidermal growth factor-activated receptor activity
GO:0007176
IGI
Genome Projectregulation of epidermal growth factor-activated receptor activity
GO:0007219
IMP, IGI
IEA
Genome ProjectNotch signaling pathway
GO:0007220
IMP
Genome ProjectNotch receptor processing
GO:0007420
IMP
Genome Projectbrain development
GO:0007507
IMP
Genome Projectheart development
GO:0007611
IGI
Genome Projectlearning or memory
GO:0007613
IMP, IGI
Genome Projectmemory
GO:0009791
IMP
Genome Projectpost-embryonic development
GO:0015031
IGI
Genome Projectprotein transport
GO:0015813
IMP
Genome ProjectL-glutamate transport
GO:0015871
IMP
Genome Projectcholine transport
GO:0016080
IMP
Genome Projectsynaptic vesicle targeting
GO:0016337
ISO
IEA
Genome Projectsingle organismal cell-cell adhesion
GO:0016485
IMP
ISS, ISO
IEA
Genome Projectprotein processing
GO:0021795
IMP
Genome Projectcerebral cortex cell migration
GO:0021870
IMP
Genome ProjectCajal-Retzius cell differentiation
GO:0021904
IGI
Genome Projectdorsal/ventral neural tube patterning
GO:0021987
IMP
Genome Projectcerebral cortex development
GO:0022008
IMP
Genome Projectneurogenesis
GO:0030182
IMP
Genome Projectneuron differentiation
GO:0030326
IGI
Genome Projectembryonic limb morphogenesis
GO:0030900
IGI
Genome Projectforebrain development
GO:0032436
IMP
Genome Projectpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032469
IMP, IGI
ISO
IEA
Genome Projectendoplasmic reticulum calcium ion homeostasis
GO:0034205
IMP
Genome Projectbeta-amyloid formation
GO:0035282
IMP
Genome Projectsegmentation
GO:0035556
IEA
Genome Projectintracellular signal transduction
GO:0040011
IGI
Genome Projectlocomotion
GO:0042325
ISO
IEA
Genome Projectregulation of phosphorylation
GO:0042987
IMP
Genome Projectamyloid precursor protein catabolic process
GO:0043011
IMP
Genome Projectmyeloid dendritic cell differentiation
GO:0043065
IGI
Genome Projectpositive regulation of apoptotic process
GO:0043066
IDA
ISO
IEA
Genome Projectnegative regulation of apoptotic process
GO:0043085
ISS, ISO
IEA
Genome Projectpositive regulation of catalytic activity
GO:0043393
IGI
Genome Projectregulation of protein binding
GO:0043406
IMP
Genome Projectpositive regulation of MAP kinase activity
GO:0043524
IEA
Genome Projectnegative regulation of neuron apoptotic process
GO:0043589
IMP
Genome Projectskin morphogenesis
GO:0044267
IDA, IMP, IGI
Genome Projectcellular protein metabolic process
GO:0045860
IDA
Genome Projectpositive regulation of protein kinase activity
GO:0045893
ISO
IEA
Genome Projectpositive regulation of transcription, DNA-templated
GO:0048167
IMP, IGI
Genome Projectregulation of synaptic plasticity
GO:0048538
IMP, IGI
Genome Projectthymus development
GO:0048666
IMP
Genome Projectneuron development
GO:0048705
IMP
Genome Projectskeletal system morphogenesis
GO:0048854
IGI
Genome Projectbrain morphogenesis
GO:0050435
IMP
Genome Projectbeta-amyloid metabolic process
GO:0050673
IGI
Genome Projectepithelial cell proliferation
GO:0050771
IMP
Genome Projectnegative regulation of axonogenesis
GO:0050820
IMP
Genome Projectpositive regulation of coagulation
GO:0050852
IGI
Genome ProjectT cell receptor signaling pathway
GO:0051402
IGI
Genome Projectneuron apoptotic process
GO:0051444
IMP
Genome Projectnegative regulation of ubiquitin-protein transferase activity
GO:0051563
IGI
Genome Projectsmooth endoplasmic reticulum calcium ion homeostasis
GO:0051604
IGI
Genome Projectprotein maturation
GO:0051966
IMP
Genome Projectregulation of synaptic transmission, glutamatergic
GO:0060070
IBA
Genome Projectcanonical Wnt signaling pathway
GO:0060075
IMP
Genome Projectregulation of resting membrane potential
GO:0060999
ISO
IEA
Genome Projectpositive regulation of dendritic spine development
GO:0070588
ISO
IEA
Genome Projectcalcium ion transmembrane transport
GO:2000059
IMP
Genome Projectnegative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2001234
IGI
Genome Projectnegative regulation of apoptotic signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004175
IMP, IGI
ISO
IEA
Genome Projectendopeptidase activity
GO:0004190
IEA
Genome Projectaspartic-type endopeptidase activity
GO:0005262
ISO
IEA
Genome Projectcalcium channel activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0008013
ISO, IBA
IEA
Genome Projectbeta-catenin binding
GO:0008233
IEA
Genome Projectpeptidase activity
GO:0016787
IEA
Genome Projecthydrolase activity
GO:0030165
ISO
IEA
Genome ProjectPDZ domain binding
GO:0045296
IPI
Genome Projectcadherin binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000139
IEA
Genome ProjectGolgi membrane
GO:0000776
ISO
IEA
Genome Projectkinetochore
GO:0005622
IDA
Genome Projectintracellular
GO:0005634
IDA
Genome Projectnucleus
GO:0005640
ISO
IEA
Genome Projectnuclear outer membrane
GO:0005739
ISS, ISO
IEA
Genome Projectmitochondrion
GO:0005743
IBA
IEA
Genome Projectmitochondrial inner membrane
GO:0005765
IBA
IEA
Genome Projectlysosomal membrane
GO:0005783
IDA
ISS, ISO
IEA
Genome Projectendoplasmic reticulum
GO:0005789
IEA
Genome Projectendoplasmic reticulum membrane
GO:0005790
ISO
IEA
Genome Projectsmooth endoplasmic reticulum
GO:0005791
ISO
IEA
Genome Projectrough endoplasmic reticulum
GO:0005794
IDA
ISS, ISO
IEA
Genome ProjectGolgi apparatus
GO:0005813
ISO
IEA
Genome Projectcentrosome
GO:0005886
IDA
ISO
TAS, IEA
Genome Projectplasma membrane
GO:0005887
ISS, ISO, IBA
IEA
Genome Projectintegral component of plasma membrane
GO:0005938
IBA
Genome Projectcell cortex
GO:0009986
IBA
IEA
Genome Projectcell surface
GO:0016020
IDA
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0016235
ISS, ISO
Genome Projectaggresome
GO:0016324
IBA
Genome Projectapical plasma membrane
GO:0030018
IBA
Genome ProjectZ disc
GO:0030424
IDA
Genome Projectaxon
GO:0030425
IDA
Genome Projectdendrite
GO:0030426
IDA
Genome Projectgrowth cone
GO:0031410
IDA
Genome Projectcytoplasmic vesicle
GO:0031594
IBA
IEA
Genome Projectneuromuscular junction
GO:0031965
ISO
IEA
Genome Projectnuclear membrane
GO:0035253
IDA
Genome Projectciliary rootlet
GO:0043005
IEA
Genome Projectneuron projection
GO:0043025
IDA
Genome Projectneuronal cell body
GO:0043198
IDA
Genome Projectdendritic shaft
GO:0043227
IDA
Genome Projectmembrane-bounded organelle
GO:0043234
IEA
Genome Projectprotein complex
GO:0045121
ISO, IBA
IEA
Genome Projectmembrane raft
GO:0048471
IBA
Genome Projectperinuclear region of cytoplasm
GO:0070765
ISO
IEA
Genome Projectgamma-secretase complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001108Peptidase A22A, presenilin
IPR002031Peptidase A22A, presenilin 1
IPR006639Presenilin/signal peptide peptidase

No MapMan annotations defined for this gene.