Gene: ENSMUSG00000019789 (Mus musculus)

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Gene Identifier
ENSMUSG00000019789
Transcript Identifier
ENSMUST00000019924
Gene Type
Coding gene
Location
10 : 30833736-30842648 : negative

Family Information

Homologous gene family
HOM03P009552
(8 genes in 3 species)
specific family
Orthologous gene family
ORTHO03P065801
(2 genes in 2 species)
specific family

Descriptions

gene_descr
hairy/enhancer-of-split related with YRPW motif 2

Identifiers

Type Value
UniprotQ9QUS4
UniprotQ0VGJ1
MGI1341884

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000122
IDA, IMP, IGI
ISO
IEA
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0001568
IGI
Genome Projectblood vessel development
GO:0001570
IGI
Genome Projectvasculogenesis
GO:0003171
IMP
Genome Projectatrioventricular valve development
GO:0003195
IMP
Genome Projecttricuspid valve formation
GO:0003199
IGI
Genome Projectendocardial cushion to mesenchymal transition involved in heart valve formation
GO:0003222
IGI
Genome Projectventricular trabecula myocardium morphogenesis
GO:0003300
IMP
Genome Projectcardiac muscle hypertrophy
GO:0006351
IEA
Genome Projecttranscription, DNA-templated
GO:0006355
IEA
Genome Projectregulation of transcription, DNA-templated
GO:0006357
ISS
Genome Projectregulation of transcription from RNA polymerase II promoter
GO:0007219
IDA
IEA
Genome ProjectNotch signaling pathway
GO:0007389
IMP, IGI
Genome Projectpattern specification process
GO:0007507
IEA
Genome Projectheart development
GO:0009948
IGI
Genome Projectanterior/posterior axis specification
GO:0010460
IMP
Genome Projectpositive regulation of heart rate
GO:0010468
IMP
Genome Projectregulation of gene expression
GO:0010629
IMP
Genome Projectnegative regulation of gene expression
GO:0010667
IMP
Genome Projectnegative regulation of cardiac muscle cell apoptotic process
GO:0014898
IDA
Genome Projectcardiac muscle hypertrophy in response to stress
GO:0045165
IMP
Genome Projectcell fate commitment
GO:0045607
IGI
Genome Projectregulation of auditory receptor cell differentiation
GO:0045892
IDA, IMP
ISO
IEA
Genome Projectnegative regulation of transcription, DNA-templated
GO:0060045
IMP
Genome Projectpositive regulation of cardiac muscle cell proliferation
GO:0060633
ISO
IEA
Genome Projectnegative regulation of transcription initiation from RNA polymerase II promoter
GO:0060840
IGI
Genome Projectartery development
GO:0060948
IMP
Genome Projectcardiac vascular smooth muscle cell development
GO:0060977
IMP
Genome Projectcoronary vasculature morphogenesis
GO:0065004
IDA
Genome Projectprotein-DNA complex assembly
GO:0090102
IMP, IGI
Genome Projectcochlea development
GO:0097084
IEA
Genome Projectvascular smooth muscle cell development
GO:2000678
IDA
ISO
IEA
Genome Projectnegative regulation of transcription regulatory region DNA binding
GO:0003150
IMP
Genome Projectmuscular septum morphogenesis
GO:0003151
IMP
Genome Projectoutflow tract morphogenesis
GO:0003184
IMP
Genome Projectpulmonary valve morphogenesis
GO:0003186
IMP
Genome Projecttricuspid valve morphogenesis
GO:0003208
IMP
Genome Projectcardiac ventricle morphogenesis
GO:0003214
IMP
Genome Projectcardiac left ventricle morphogenesis
GO:0003215
IMP
Genome Projectcardiac right ventricle morphogenesis
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0014031
IMP
Genome Projectmesenchymal cell development
GO:0035910
IMP
Genome Projectascending aorta morphogenesis
GO:0035912
IGI
Genome Projectdorsal aorta morphogenesis
GO:0036304
IGI
Genome Projectumbilical cord morphogenesis
GO:0045746
IDA, IMP
Genome Projectnegative regulation of Notch signaling pathway
GO:0045944
IMP
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0055015
IMP
Genome Projectventricular cardiac muscle cell development
GO:0060317
IMP
Genome Projectcardiac epithelial to mesenchymal transition
GO:0060347
IMP
Genome Projectheart trabecula formation
GO:0060411
IMP
Genome Projectcardiac septum morphogenesis
GO:0060412
IMP
Genome Projectventricular septum morphogenesis
GO:0060413
IMP
Genome Projectatrial septum morphogenesis
GO:0060716
IGI
Genome Projectlabyrinthine layer blood vessel development
GO:0060842
IGI
Genome Projectarterial endothelial cell differentiation
GO:0061156
IMP
Genome Projectpulmonary artery morphogenesis
GO:0061314
IC
Genome ProjectNotch signaling involved in heart development
GO:2000820
IDA
Genome Projectnegative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation
GO:2001212
IGI
Genome Projectregulation of vasculogenesis

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000988
IEA
Genome Projecttranscription factor activity, protein binding
GO:0001102
ISO
IEA
Genome ProjectRNA polymerase II activating transcription factor binding
GO:0003677
IMP
IEA
Genome ProjectDNA binding
GO:0003700
IDA
ISS, ISO
IEA
Genome Projecttranscription factor activity, sequence-specific DNA binding
GO:0008134
IPI
Genome Projecttranscription factor binding
GO:0035939
IDA
ISO
IEA
Genome Projectmicrosatellite binding
GO:0042826
ISO
IEA
Genome Projecthistone deacetylase binding
GO:0043565
IDA
ISO
IEA
Genome Projectsequence-specific DNA binding
GO:0046983
IEA
Genome Projectprotein dimerization activity
GO:0000983
IDA
Genome Projecttranscription factor activity, RNA polymerase II core promoter sequence-specific
GO:0005515
IPI
Genome Projectprotein binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005667
ISS
Genome Projecttranscription factor complex
GO:0016580
ISO
IEA
Genome ProjectSin3 complex
GO:0017053
ISO
IEA
Genome Projecttranscriptional repressor complex
GO:0005654
TAS
Genome Projectnucleoplasm
GO:0005737
IDA
Genome Projectcytoplasm

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR003650Orange domain
IPR011598Myc-type, basic helix-loop-helix (bHLH) domain

No MapMan annotations defined for this gene.