Gene: ENSMUSG00000018634 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000018634
Transcript Identifier
ENSMUST00000093925
Gene Type
Coding gene
Location
11 : 104133072-104174528 : positive

Family Information

Homologous gene family
HOM03P002772
(34 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P010002
(8 genes in 4 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
corticotropin releasing hormone receptor 1

Identifiers

Type Value
UniprotP35347
UniprotQ3ZAT0
MGI88498

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001666
IEA
Genome Projectresponse to hypoxia
GO:0007165
IEA
Genome Projectsignal transduction
GO:0007166
IEA
Genome Projectcell surface receptor signaling pathway
GO:0007186
IEA
Genome ProjectG-protein coupled receptor signaling pathway
GO:0007188
IEA
Genome Projectadenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007189
IEA
Genome Projectadenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007200
IEA
Genome Projectphospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204
IEA
Genome Projectpositive regulation of cytosolic calcium ion concentration
GO:0007218
IEA
Genome Projectneuropeptide signaling pathway
GO:0007613
IEA
Genome Projectmemory
GO:0007631
IEA
Genome Projectfeeding behavior
GO:0008542
IEA
Genome Projectvisual learning
GO:0009755
IEA
Genome Projecthormone-mediated signaling pathway
GO:0010578
ISO
IEA
Genome Projectregulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
GO:0010579
IMP
ISO
IEA
Genome Projectpositive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
GO:0021854
IEA
Genome Projecthypothalamus development
GO:0030325
IMP
Genome Projectadrenal gland development
GO:0030819
IEA
Genome Projectpositive regulation of cAMP biosynthetic process
GO:0030855
IEA
Genome Projectepithelial cell differentiation
GO:0032811
IEA
Genome Projectnegative regulation of epinephrine secretion
GO:0035641
IEA
Genome Projectlocomotory exploration behavior
GO:0035902
IEA
Genome Projectresponse to immobilization stress
GO:0042596
IMP
Genome Projectfear response
GO:0043306
IEA
Genome Projectpositive regulation of mast cell degranulation
GO:0048148
IEA
Genome Projectbehavioral response to cocaine
GO:0048149
IMP
Genome Projectbehavioral response to ethanol
GO:0048167
IEA
Genome Projectregulation of synaptic plasticity
GO:0048266
IEA
Genome Projectbehavioral response to pain
GO:0051458
IMP
Genome Projectcorticotropin secretion
GO:0051602
IEA
Genome Projectresponse to electrical stimulus
GO:0051867
IMP
Genome Projectgeneral adaptation syndrome, behavioral process
GO:0060291
IEA
Genome Projectlong-term synaptic potentiation
GO:0071376
IMP
ISO
IEA
Genome Projectcellular response to corticotropin-releasing hormone stimulus
GO:1901215
IEA
Genome Projectnegative regulation of neuron death
GO:1901386
ISO
IEA
Genome Projectnegative regulation of voltage-gated calcium channel activity
GO:2000252
IEA
Genome Projectnegative regulation of feeding behavior
GO:2000852
IMP
Genome Projectregulation of corticosterone secretion

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001965
IEA
Genome ProjectG-protein alpha-subunit binding
GO:0004871
IEA
Genome Projectsignal transducer activity
GO:0004888
IEA
Genome Projecttransmembrane signaling receptor activity
GO:0004930
IEA
Genome ProjectG-protein coupled receptor activity
GO:0015056
IMP
ISO
IEA
Genome Projectcorticotrophin-releasing factor receptor activity
GO:0032403
IEA
Genome Projectprotein complex binding
GO:0042277
IEA
Genome Projectpeptide binding
GO:0043404
IEA
Genome Projectcorticotropin-releasing hormone receptor activity
GO:0051424
IEA
Genome Projectcorticotropin-releasing hormone binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005768
IEA
Genome Projectendosome
GO:0005771
IEA
Genome Projectmultivesicular body
GO:0005802
IEA
Genome Projecttrans-Golgi network
GO:0005829
IEA
Genome Projectcytosol
GO:0005886
IEA
Genome Projectplasma membrane
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
ISO
IEA
Genome Projectintegral component of membrane
GO:0030425
IEA
Genome Projectdendrite
GO:0031226
ISS, ISO
IEA
Genome Projectintrinsic component of plasma membrane
GO:0031982
IEA
Genome Projectvesicle
GO:0043025
IEA
Genome Projectneuronal cell body
GO:0045177
IEA
Genome Projectapical part of cell

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000832GPCR, family 2, secretin-like
IPR001879GPCR, family 2, extracellular hormone receptor domain
IPR003051GPCR, family 2, corticotropin releasing factor receptor
IPR003052GPCR, family 2, corticotropin releasing factor receptor, type 1
IPR017981GPCR, family 2-like
IPR017983GPCR, family 2, secretin-like, conserved site

No MapMan annotations defined for this gene.