Gene: ENSMUSG00000018166 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000018166
Transcript Identifier
ENSMUST00000082059
Gene Type
Coding gene
Location
10 : 128569368-128589501 : negative

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P009161
(9 genes in 4 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)

Identifiers

Type Value
UniprotQ61526
MGI95411

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0003197
IMP
Genome Projectendocardial cushion development
GO:0006468
IEA
Genome Projectprotein phosphorylation
GO:0007162
ISO
IEA
Genome Projectnegative regulation of cell adhesion
GO:0007165
ISO
IEA
Genome Projectsignal transduction
GO:0007169
ISO
IEA
Genome Projecttransmembrane receptor protein tyrosine kinase signaling pathway
GO:0007422
IMP
Genome Projectperipheral nervous system development
GO:0009968
ISO
IEA
Genome Projectnegative regulation of signal transduction
GO:0014037
IMP
Genome ProjectSchwann cell differentiation
GO:0014065
ISO
IEA
Genome Projectphosphatidylinositol 3-kinase signaling
GO:0016310
IEA
Genome Projectphosphorylation
GO:0021545
IMP
Genome Projectcranial nerve development
GO:0042127
ISO
IEA
Genome Projectregulation of cell proliferation
GO:0043524
IMP
Genome Projectnegative regulation of neuron apoptotic process
GO:0051048
ISO
IEA
Genome Projectnegative regulation of secretion
GO:0051402
ISO
IEA
Genome Projectneuron apoptotic process
GO:0061098
ISO
IEA
Genome Projectpositive regulation of protein tyrosine kinase activity
GO:0070886
IGI
Genome Projectpositive regulation of calcineurin-NFAT signaling cascade
GO:0097192
ISO
IEA
Genome Projectextrinsic apoptotic signaling pathway in absence of ligand

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
IEA
Genome Projectprotein kinase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0019838
ISO
IEA
Genome Projectgrowth factor binding
GO:0030296
ISO
IEA
Genome Projectprotein tyrosine kinase activator activity
GO:0042802
ISO
IEA
Genome Projectidentical protein binding
GO:0046982
ISO
IEA
Genome Projectprotein heterodimerization activity
GO:0004713
ISO
Genome Projectprotein tyrosine kinase activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005615
ISO
IEA
Genome Projectextracellular space
GO:0005622
ISO
Genome Projectintracellular
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0016323
ISO
IEA
Genome Projectbasolateral plasma membrane
GO:0016324
IDA
Genome Projectapical plasma membrane
GO:0016328
IDA
Genome Projectlateral plasma membrane
GO:0043235
ISO
IEA
Genome Projectreceptor complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000494Receptor L-domain
IPR000719Protein kinase domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR006211Furin-like cysteine-rich domain
IPR006212Furin-like repeat
IPR008266Tyrosine-protein kinase, active site
IPR009030Growth factor receptor cysteine-rich domain
IPR011009Protein kinase-like domain
IPR016245Tyrosine protein kinase, EGF/ERB/XmrK receptor
IPR020635Tyrosine-protein kinase, catalytic domain

No MapMan annotations defined for this gene.