Gene: ENSMUSG00000010609 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000010609
Transcript Identifier
ENSMUST00000111105
Gene Type
Coding gene
Location
1 : 180227573-180245754 : negative

Family Information

Homologous gene family
HOM03P001593
(48 genes in 34 species)
specific family
Orthologous gene family
ORTHO03P001201
(40 genes in 33 species)
specific family

Descriptions

gene_descr
presenilin 2

Identifiers

Type Value
UniprotQ3U4P5
MGI109284

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001708
IGI
Genome Projectcell fate specification
GO:0001756
IGI
Genome Projectsomitogenesis
GO:0001933
IGI
Genome Projectnegative regulation of protein phosphorylation
GO:0001942
IGI
Genome Projecthair follicle development
GO:0002244
IGI
Genome Projecthematopoietic progenitor cell differentiation
GO:0002286
IGI
Genome ProjectT cell activation involved in immune response
GO:0002573
IGI
Genome Projectmyeloid leukocyte differentiation
GO:0006508
IEA
Genome Projectproteolysis
GO:0006509
ISO, IBA
IEA
Genome Projectmembrane protein ectodomain proteolysis
GO:0007176
IGI
Genome Projectregulation of epidermal growth factor-activated receptor activity
GO:0007219
IGI
IEA
Genome ProjectNotch signaling pathway
GO:0007220
IBA
Genome ProjectNotch receptor processing
GO:0007611
IGI
Genome Projectlearning or memory
GO:0007613
IGI
Genome Projectmemory
GO:0015031
IGI
Genome Projectprotein transport
GO:0016485
IGI
ISO
IEA
Genome Projectprotein processing
GO:0021904
IGI
Genome Projectdorsal/ventral neural tube patterning
GO:0030326
IGI
Genome Projectembryonic limb morphogenesis
GO:0030900
IGI
Genome Projectforebrain development
GO:0031333
IDA
Genome Projectnegative regulation of protein complex assembly
GO:0032091
IDA
Genome Projectnegative regulation of protein binding
GO:0032469
IGI
Genome Projectendoplasmic reticulum calcium ion homeostasis
GO:0035556
IEA
Genome Projectintracellular signal transduction
GO:0040011
IGI
Genome Projectlocomotion
GO:0042987
IBA
Genome Projectamyloid precursor protein catabolic process
GO:0043065
IGI
Genome Projectpositive regulation of apoptotic process
GO:0043085
ISO
IEA
Genome Projectpositive regulation of catalytic activity
GO:0043393
IGI
Genome Projectregulation of protein binding
GO:0044267
IGI
Genome Projectcellular protein metabolic process
GO:0048167
IGI
Genome Projectregulation of synaptic plasticity
GO:0048286
IMP
Genome Projectlung alveolus development
GO:0048538
IGI
Genome Projectthymus development
GO:0048854
IGI
Genome Projectbrain morphogenesis
GO:0050435
IDA, IMP
Genome Projectbeta-amyloid metabolic process
GO:0050820
IMP
Genome Projectpositive regulation of coagulation
GO:0050852
IGI
Genome ProjectT cell receptor signaling pathway
GO:0051604
IGI
Genome Projectprotein maturation
GO:0060048
IMP
Genome Projectcardiac muscle contraction
GO:1902042
IDA
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001234
IGI
Genome Projectnegative regulation of apoptotic signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004175
IMP, IGI
Genome Projectendopeptidase activity
GO:0004190
IEA
Genome Projectaspartic-type endopeptidase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0008233
IEA
Genome Projectpeptidase activity
GO:0016787
IEA
Genome Projecthydrolase activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000139
IEA
Genome ProjectGolgi membrane
GO:0000776
ISO
IEA
Genome Projectkinetochore
GO:0005634
IBA
Genome Projectnucleus
GO:0005637
ISO
IEA
Genome Projectnuclear inner membrane
GO:0005743
IBA
Genome Projectmitochondrial inner membrane
GO:0005765
IBA
Genome Projectlysosomal membrane
GO:0005783
IDA
ISO
IEA
Genome Projectendoplasmic reticulum
GO:0005789
IEA
Genome Projectendoplasmic reticulum membrane
GO:0005794
ISO
IEA
Genome ProjectGolgi apparatus
GO:0005813
ISO
IEA
Genome Projectcentrosome
GO:0005829
IDA
Genome Projectcytosol
GO:0005887
ISO, IBA
IEA
Genome Projectintegral component of plasma membrane
GO:0005938
IBA
Genome Projectcell cortex
GO:0009986
IBA
Genome Projectcell surface
GO:0016020
IDA
ISO
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0016324
IBA
Genome Projectapical plasma membrane
GO:0030018
IDA
Genome ProjectZ disc
GO:0030424
IBA
Genome Projectaxon
GO:0030426
IBA
Genome Projectgrowth cone
GO:0031594
IBA
Genome Projectneuromuscular junction
GO:0035253
IBA
Genome Projectciliary rootlet
GO:0036064
IDA
Genome Projectciliary basal body
GO:0043025
IDA
Genome Projectneuronal cell body
GO:0043198
IBA
Genome Projectdendritic shaft
GO:0043234
ISO
IEA
Genome Projectprotein complex
GO:0045121
IBA
Genome Projectmembrane raft
GO:0048471
IBA
Genome Projectperinuclear region of cytoplasm

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001108Peptidase A22A, presenilin
IPR001493Peptidase A22A, presenilin 2
IPR006639Presenilin/signal peptide peptidase

No MapMan annotations defined for this gene.