Gene: ENSMUSG00000007613 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000007613
Transcript Identifier
ENSMUST00000007757
Gene Type
Coding gene
Location
4 : 47353312-47410777 : positive

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P010260
(8 genes in 4 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
transforming growth factor, beta receptor I

Identifiers

Type Value
UniprotQ64729
UniprotQ4FJL1
MGI98728

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000186
ISO
IEA
Genome Projectactivation of MAPKK activity
GO:0001501
IGI
Genome Projectskeletal system development
GO:0001525
IMP
Genome Projectangiogenesis
GO:0001701
IMP
Genome Projectin utero embryonic development
GO:0001822
IGI
Genome Projectkidney development
GO:0001824
IDA
Genome Projectblastocyst development
GO:0001837
ISO
IEA
Genome Projectepithelial to mesenchymal transition
GO:0001937
IGI
Genome Projectnegative regulation of endothelial cell proliferation
GO:0001938
ISS
Genome Projectpositive regulation of endothelial cell proliferation
GO:0002088
IMP
Genome Projectlens development in camera-type eye
GO:0006355
ISO
IEA
Genome Projectregulation of transcription, DNA-templated
GO:0006468
ISO
IEA
Genome Projectprotein phosphorylation
GO:0007165
ISO
IEA
Genome Projectsignal transduction
GO:0007178
IEA
Genome Projecttransmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007179
IDA, IMP
ISS, ISO
Genome Projecttransforming growth factor beta receptor signaling pathway
GO:0007507
IMP
ISS
Genome Projectheart development
GO:0008284
ISO
IEA
Genome Projectpositive regulation of cell proliferation
GO:0008354
IMP
Genome Projectgerm cell migration
GO:0008584
IMP
Genome Projectmale gonad development
GO:0009791
IMP
Genome Projectpost-embryonic development
GO:0009952
IGI
Genome Projectanterior/posterior pattern specification
GO:0010468
IMP
ISS
Genome Projectregulation of gene expression
GO:0010628
ISS
Genome Projectpositive regulation of gene expression
GO:0010717
ISS
Genome Projectregulation of epithelial to mesenchymal transition
GO:0010862
ISO
IEA
Genome Projectpositive regulation of pathway-restricted SMAD protein phosphorylation
GO:0016310
IEA
Genome Projectphosphorylation
GO:0018105
ISO
IEA
Genome Projectpeptidyl-serine phosphorylation
GO:0018107
ISO
IEA
Genome Projectpeptidyl-threonine phosphorylation
GO:0023014
IEA
Genome Projectsignal transduction by protein phosphorylation
GO:0030199
IMP
Genome Projectcollagen fibril organization
GO:0030307
ISO
IEA
Genome Projectpositive regulation of cell growth
GO:0031396
ISO
IEA
Genome Projectregulation of protein ubiquitination
GO:0032924
ISS
Genome Projectactivin receptor signaling pathway
GO:0035556
ISS
Genome Projectintracellular signal transduction
GO:0042118
ISS
Genome Projectendothelial cell activation
GO:0043066
IMP
Genome Projectnegative regulation of apoptotic process
GO:0043393
IMP
Genome Projectregulation of protein binding
GO:0043542
IMP
Genome Projectendothelial cell migration
GO:0045893
ISS, ISO
Genome Projectpositive regulation of transcription, DNA-templated
GO:0048538
IMP
Genome Projectthymus development
GO:0048663
IMP
Genome Projectneuron fate commitment
GO:0048701
IMP
Genome Projectembryonic cranial skeleton morphogenesis
GO:0048705
IGI
Genome Projectskeletal system morphogenesis
GO:0048762
ISS
Genome Projectmesenchymal cell differentiation
GO:0048844
IMP
Genome Projectartery morphogenesis
GO:0048870
ISO
IEA
Genome Projectcell motility
GO:0051272
ISO
IEA
Genome Projectpositive regulation of cellular component movement
GO:0051491
IMP
Genome Projectpositive regulation of filopodium assembly
GO:0051897
ISO
IEA
Genome Projectpositive regulation of protein kinase B signaling
GO:0060017
IMP
Genome Projectparathyroid gland development
GO:0060021
IMP, IGI
Genome Projectpalate development
GO:0060037
IMP
Genome Projectpharyngeal system development
GO:0060317
ISS
Genome Projectcardiac epithelial to mesenchymal transition
GO:0060389
ISO
IEA
Genome Projectpathway-restricted SMAD protein phosphorylation
GO:0060391
ISO
IEA
Genome Projectpositive regulation of SMAD protein import into nucleus
GO:0070723
IDA
ISO
IEA
Genome Projectresponse to cholesterol
GO:0071560
IDA
ISO
IEA
Genome Projectcellular response to transforming growth factor beta stimulus
GO:2001235
ISO
IEA
Genome Projectpositive regulation of apoptotic signaling pathway
GO:2001237
ISO
IEA
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway
GO:0006915
IEA
Genome Projectapoptotic process
GO:0030154
IEA
Genome Projectcell differentiation
GO:0032331
IMP
Genome Projectnegative regulation of chondrocyte differentiation
GO:0040008
IEA
Genome Projectregulation of growth

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
ISO
IEA
Genome Projectprotein kinase activity
GO:0004674
ISO
IEA
Genome Projectprotein serine/threonine kinase activity
GO:0004675
IEA
Genome Projecttransmembrane receptor protein serine/threonine kinase activity
GO:0004702
IEA
Genome Projectreceptor signaling protein serine/threonine kinase activity
GO:0005024
IDA, IGI
ISO
IEA
Genome Projecttransforming growth factor beta-activated receptor activity
GO:0005025
ISS, ISO
Genome Projecttransforming growth factor beta receptor activity, type I
GO:0005057
ISS
Genome Projectreceptor signaling protein activity
GO:0005114
ISO
IEA
Genome Projecttype II transforming growth factor beta receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
ISO
IEA
Genome ProjectATP binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0019838
ISO
IEA
Genome Projectgrowth factor binding
GO:0046332
IDA
ISO
IEA
Genome ProjectSMAD binding
GO:0050431
IPI
ISS, ISO
Genome Projecttransforming growth factor beta binding
GO:0070411
ISO
IEA
Genome ProjectI-SMAD binding
GO:0046872
IEA
Genome Projectmetal ion binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005622
ISS
Genome Projectintracellular
GO:0005623
ISS
Genome Projectcell
GO:0005886
ISO
IEA
Genome Projectplasma membrane
GO:0005901
ISO
Genome Projectcaveola
GO:0005923
ISO
IEA
Genome Projectbicellular tight junction
GO:0016020
ISS
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0043235
ISO
IEA
Genome Projectreceptor complex
GO:0045121
ISO
Genome Projectmembrane raft
GO:0005768
IDA
Genome Projectendosome
GO:0030054
IEA
Genome Projectcell junction

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000333Ser/Thr protein kinase, TGFB receptor
IPR000472Activin types I and II receptor domain
IPR000719Protein kinase domain
IPR003605GS domain
IPR008271Serine/threonine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR017441Protein kinase, ATP binding site

No MapMan annotations defined for this gene.