Gene: ENSMUSG00000006818 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000006818
Transcript Identifier
ENSMUST00000007012
Gene Type
Coding gene
Location
17 : 13008046-13015171 : positive

Family Information

Homologous gene family
HOM03P000403
(111 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P001387
(38 genes in 37 species)
specific family

Descriptions

gene_descr
superoxide dismutase 2, mitochondrial

Identifiers

Type Value
UniprotP09671
UniprotQ4FJX9
MGI98352

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000302
IMP
Genome Projectresponse to reactive oxygen species
GO:0000303
IMP
ISO
Genome Projectresponse to superoxide
GO:0001306
IMP
Genome Projectage-dependent response to oxidative stress
GO:0001315
ISS, ISO
Genome Projectage-dependent response to reactive oxygen species
GO:0001666
IEA
Genome Projectresponse to hypoxia
GO:0001836
IMP
Genome Projectrelease of cytochrome c from mitochondria
GO:0001889
IMP
Genome Projectliver development
GO:0003032
IMP
Genome Projectdetection of oxygen
GO:0003069
IMP
Genome Projectvasodilation by acetylcholine involved in regulation of systemic arterial blood pressure
GO:0006357
IDA
ISS, ISO
Genome Projectregulation of transcription from RNA polymerase II promoter
GO:0006749
IMP
Genome Projectglutathione metabolic process
GO:0006801
IMP
ISS, ISO
IEA
Genome Projectsuperoxide metabolic process
GO:0006979
IMP, IGI
IEA
Genome Projectresponse to oxidative stress
GO:0007005
IMP
Genome Projectmitochondrion organization
GO:0007507
IMP
Genome Projectheart development
GO:0007568
IEA
Genome Projectaging
GO:0007626
IMP
Genome Projectlocomotory behavior
GO:0008217
IMP
Genome Projectregulation of blood pressure
GO:0008285
ISO
Genome Projectnegative regulation of cell proliferation
GO:0008630
IMP
Genome Projectintrinsic apoptotic signaling pathway in response to DNA damage
GO:0008631
IMP
Genome Projectintrinsic apoptotic signaling pathway in response to oxidative stress
GO:0008637
IMP
Genome Projectapoptotic mitochondrial changes
GO:0009314
IEA
Genome Projectresponse to radiation
GO:0009409
IEA
Genome Projectresponse to cold
GO:0009791
IMP
Genome Projectpost-embryonic development
GO:0010042
IEA
Genome Projectresponse to manganese ion
GO:0010043
IEA
Genome Projectresponse to zinc ion
GO:0010269
IEA
Genome Projectresponse to selenium ion
GO:0010332
IGI
Genome Projectresponse to gamma radiation
GO:0014823
IMP
IEA
Genome Projectresponse to activity
GO:0019430
IMP
ISO
IEA
Genome Projectremoval of superoxide radicals
GO:0022904
IMP
Genome Projectrespiratory electron transport chain
GO:0030097
IMP
Genome Projecthemopoiesis
GO:0031667
IEA
Genome Projectresponse to nutrient levels
GO:0032364
ISO
Genome Projectoxygen homeostasis
GO:0032496
IEA
Genome Projectresponse to lipopolysaccharide
GO:0033591
IEA
Genome Projectresponse to L-ascorbic acid
GO:0034021
IEA
Genome Projectresponse to silicon dioxide
GO:0035900
IEA
Genome Projectresponse to isolation stress
GO:0035902
IEA
Genome Projectresponse to immobilization stress
GO:0042311
IMP
Genome Projectvasodilation
GO:0042493
IEA
Genome Projectresponse to drug
GO:0042542
IMP
IEA
Genome Projectresponse to hydrogen peroxide
GO:0042554
IMP
Genome Projectsuperoxide anion generation
GO:0042743
IEA
Genome Projecthydrogen peroxide metabolic process
GO:0043066
IEA
Genome Projectnegative regulation of apoptotic process
GO:0043524
ISO
Genome Projectnegative regulation of neuron apoptotic process
GO:0045429
IMP
Genome Projectpositive regulation of nitric oxide biosynthetic process
GO:0045599
IMP
Genome Projectnegative regulation of fat cell differentiation
GO:0046686
IEA
Genome Projectresponse to cadmium ion
GO:0048147
IDA
Genome Projectnegative regulation of fibroblast proliferation
GO:0048666
IMP
Genome Projectneuron development
GO:0048678
IMP
Genome Projectresponse to axon injury
GO:0048773
IMP
Genome Projecterythrophore differentiation
GO:0050665
IEA
Genome Projecthydrogen peroxide biosynthetic process
GO:0050790
IMP
Genome Projectregulation of catalytic activity
GO:0051260
IEA
Genome Projectprotein homooligomerization
GO:0051289
ISO
Genome Projectprotein homotetramerization
GO:0051602
IEA
Genome Projectresponse to electrical stimulus
GO:0051881
IMP
Genome Projectregulation of mitochondrial membrane potential
GO:0055072
IMP
Genome Projectiron ion homeostasis
GO:0055093
IMP
Genome Projectresponse to hyperoxia
GO:0055114
IEA
Genome Projectoxidation-reduction process
GO:0071000
IEA
Genome Projectresponse to magnetism
GO:0071361
IEA
Genome Projectcellular response to ethanol
GO:1902176
ISO
Genome Projectnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:0007605
IMP
Genome Projectsensory perception of sound

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0003677
IEA
Genome ProjectDNA binding
GO:0004784
IDA, IMP
ISS, ISO
IEA
Genome Projectsuperoxide dismutase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0016491
IMP
IEA
Genome Projectoxidoreductase activity
GO:0019825
IEA
Genome Projectoxygen binding
GO:0030145
ISS, ISO
Genome Projectmanganese ion binding
GO:0042802
ISO
IEA
Genome Projectidentical protein binding
GO:0046872
IEA
Genome Projectmetal ion binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
IEA
Genome Projectcytoplasm
GO:0005739
IDA
ISO
IEA
Genome Projectmitochondrion
GO:0005743
IDA
Genome Projectmitochondrial inner membrane
GO:0005759
IEA
Genome Projectmitochondrial matrix
GO:0042645
IEA
Genome Projectmitochondrial nucleoid
GO:0043209
IDA
Genome Projectmyelin sheath
GO:0070062
ISO
Genome Projectextracellular exosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001189Manganese/iron superoxide dismutase
IPR019831Manganese/iron superoxide dismutase, N-terminal
IPR019832Manganese/iron superoxide dismutase, C-terminal
IPR019833Manganese/iron superoxide dismutase, binding site

No MapMan annotations defined for this gene.