Gene: ENSMUSG00000005534 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000005534
Transcript Identifier
ENSMUST00000091291
Gene Type
Coding gene
Location
8 : 3155669-3279128 : negative

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P011940
(7 genes in 4 species)
specific family

Descriptions

gene_descr
insulin receptor

Identifiers

Type Value
UniprotP15208
MGI96575

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000187
ISO
IEA
Genome Projectactivation of MAPK activity
GO:0001934
ISO
IEA
Genome Projectpositive regulation of protein phosphorylation
GO:0003007
ISO
IEA
Genome Projectheart morphogenesis
GO:0006355
ISO
IEA
Genome Projectregulation of transcription, DNA-templated
GO:0006468
IEA
Genome Projectprotein phosphorylation
GO:0007169
IEA
Genome Projecttransmembrane receptor protein tyrosine kinase signaling pathway
GO:0007186
ISO
IEA
Genome ProjectG-protein coupled receptor signaling pathway
GO:0008284
ISO
Genome Projectpositive regulation of cell proliferation
GO:0008286
IMP
ISO
IEA
Genome Projectinsulin receptor signaling pathway
GO:0008544
IMP
Genome Projectepidermis development
GO:0008584
IGI
Genome Projectmale gonad development
GO:0009887
IMP
Genome Projectorgan morphogenesis
GO:0016310
IEA
Genome Projectphosphorylation
GO:0018108
ISO
IEA
Genome Projectpeptidyl-tyrosine phosphorylation
GO:0019087
ISO
IEA
Genome Projecttransformation of host cell by virus
GO:0023014
ISO
IEA
Genome Projectsignal transduction by protein phosphorylation
GO:0030238
IMP
Genome Projectmale sex determination
GO:0030325
IGI
Genome Projectadrenal gland development
GO:0030335
ISO
IEA
Genome Projectpositive regulation of cell migration
GO:0031017
IMP
Genome Projectexocrine pancreas development
GO:0032147
ISO
IEA
Genome Projectactivation of protein kinase activity
GO:0032148
ISO
IEA
Genome Projectactivation of protein kinase B activity
GO:0032869
ISO
IEA
Genome Projectcellular response to insulin stimulus
GO:0038083
IDA
Genome Projectpeptidyl-tyrosine autophosphorylation
GO:0042593
ISO
IEA
Genome Projectglucose homeostasis
GO:0043410
ISO
IEA
Genome Projectpositive regulation of MAPK cascade
GO:0045429
ISO
IEA
Genome Projectpositive regulation of nitric oxide biosynthetic process
GO:0045725
IMP
ISO
IEA
Genome Projectpositive regulation of glycogen biosynthetic process
GO:0045740
ISO
IEA
Genome Projectpositive regulation of DNA replication
GO:0045821
ISO
IEA
Genome Projectpositive regulation of glycolytic process
GO:0045840
IMP
ISO
IEA
Genome Projectpositive regulation of mitotic nuclear division
GO:0045893
IGI
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045995
ISO
IEA
Genome Projectregulation of embryonic development
GO:0046326
ISO
Genome Projectpositive regulation of glucose import
GO:0046777
ISS, ISO
IEA
Genome Projectprotein autophosphorylation
GO:0048639
ISO
IEA
Genome Projectpositive regulation of developmental growth
GO:0051290
ISS, ISO
IEA
Genome Projectprotein heterotetramerization
GO:0051446
IGI
Genome Projectpositive regulation of meiotic cell cycle
GO:0051897
ISO
IEA
Genome Projectpositive regulation of protein kinase B signaling
GO:0060267
ISO
IEA
Genome Projectpositive regulation of respiratory burst
GO:0071363
IDA
Genome Projectcellular response to growth factor stimulus
GO:2000194
IGI
Genome Projectregulation of female gonad development

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
IEA
Genome Projectprotein kinase activity
GO:0004713
ISO
IEA
Genome Projectprotein tyrosine kinase activity
GO:0004714
IEA
Genome Projecttransmembrane receptor protein tyrosine kinase activity
GO:0004716
ISO
IEA
Genome Projectreceptor signaling protein tyrosine kinase activity
GO:0005009
ISS, ISO
IEA
Genome Projectinsulin-activated receptor activity
GO:0005159
ISO
IEA
Genome Projectinsulin-like growth factor receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
ISO
IEA
Genome ProjectATP binding
GO:0005525
ISO
IEA
Genome ProjectGTP binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0031994
ISO
IEA
Genome Projectinsulin-like growth factor I binding
GO:0031995
ISO
IEA
Genome Projectinsulin-like growth factor II binding
GO:0043548
ISS, ISO
IEA
Genome Projectphosphatidylinositol 3-kinase binding
GO:0043559
ISS, ISO
IEA
Genome Projectinsulin binding
GO:0043560
ISS, ISO
IEA
Genome Projectinsulin receptor substrate binding
GO:0051425
ISS, ISO
IEA
Genome ProjectPTB domain binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005886
IDA
IEA
Genome Projectplasma membrane
GO:0005887
ISO
IEA
Genome Projectintegral component of plasma membrane
GO:0005899
ISO
IEA
Genome Projectinsulin receptor complex
GO:0005901
IDA
ISO
IEA
Genome Projectcaveola
GO:0016020
IDA
ISO
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0043231
ISO
IEA
Genome Projectintracellular membrane-bounded organelle
GO:0043235
ISO
IEA
Genome Projectreceptor complex
GO:0070062
ISO
IEA
Genome Projectextracellular exosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000494Receptor L-domain
IPR000719Protein kinase domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002011Tyrosine-protein kinase, receptor class II, conserved site
IPR003961Fibronectin type III
IPR006211Furin-like cysteine-rich domain
IPR006212Furin-like repeat
IPR008266Tyrosine-protein kinase, active site
IPR009030Growth factor receptor cysteine-rich domain
IPR011009Protein kinase-like domain
IPR013783Immunoglobulin-like fold
IPR016246Tyrosine-protein kinase, insulin-like receptor
IPR017441Protein kinase, ATP binding site
IPR020635Tyrosine-protein kinase, catalytic domain

No MapMan annotations defined for this gene.