Gene: ENSMUSG00000005533 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000005533
Transcript Identifier
ENSMUST00000005671
Gene Type
Coding gene
Location
7 : 67952859-68226401 : positive

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P011940
(7 genes in 4 species)
specific family
Duplication type
Tandem duplicate   and   Block duplicate

Descriptions

gene_descr
insulin-like growth factor I receptor

Identifiers

Type Value
UniprotE9QNX9
MGI96433

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0006468
IDA
IEA
Genome Projectprotein phosphorylation
GO:0006955
ISO
IEA
Genome Projectimmune response
GO:0007169
IEA
Genome Projecttransmembrane receptor protein tyrosine kinase signaling pathway
GO:0007409
IEA
Genome Projectaxonogenesis
GO:0007420
IMP
Genome Projectbrain development
GO:0008544
IMP
Genome Projectepidermis development
GO:0009887
IMP
Genome Projectorgan morphogenesis
GO:0010656
IEA
Genome Projectnegative regulation of muscle cell apoptotic process
GO:0016310
IEA
Genome Projectphosphorylation
GO:0030010
IEA
Genome Projectestablishment of cell polarity
GO:0030238
IMP
Genome Projectmale sex determination
GO:0030335
ISO
IEA
Genome Projectpositive regulation of cell migration
GO:0030879
IMP
Genome Projectmammary gland development
GO:0031017
IMP
Genome Projectexocrine pancreas development
GO:0031175
IEA
Genome Projectneuron projection development
GO:0032467
IEA
Genome Projectpositive regulation of cytokinesis
GO:0033197
IEA
Genome Projectresponse to vitamin E
GO:0038083
IDA
ISO
IEA
Genome Projectpeptidyl-tyrosine autophosphorylation
GO:0043066
ISO
IEA
Genome Projectnegative regulation of apoptotic process
GO:0043409
IMP
Genome Projectnegative regulation of MAPK cascade
GO:0043410
IMP
Genome Projectpositive regulation of MAPK cascade
GO:0043433
IMP
Genome Projectnegative regulation of sequence-specific DNA binding transcription factor activity
GO:0045740
ISO
IEA
Genome Projectpositive regulation of DNA replication
GO:0045840
IMP
Genome Projectpositive regulation of mitotic nuclear division
GO:0046328
ISO
IEA
Genome Projectregulation of JNK cascade
GO:0046777
ISO
IEA
Genome Projectprotein autophosphorylation
GO:0048009
ISO
IC, IEA
Genome Projectinsulin-like growth factor receptor signaling pathway
GO:0048015
ISO
IEA
Genome Projectphosphatidylinositol-mediated signaling
GO:0051054
IEA
Genome Projectpositive regulation of DNA metabolic process
GO:0051262
ISO
IEA
Genome Projectprotein tetramerization
GO:0051291
IEA
Genome Projectprotein heterooligomerization
GO:0051389
ISO
IEA
Genome Projectinactivation of MAPKK activity
GO:0051897
IMP
Genome Projectpositive regulation of protein kinase B signaling
GO:0051898
IMP
Genome Projectnegative regulation of protein kinase B signaling
GO:0060740
IMP
Genome Projectprostate gland epithelium morphogenesis
GO:0090031
IEA
Genome Projectpositive regulation of steroid hormone biosynthetic process

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0001965
IEA
Genome ProjectG-protein alpha-subunit binding
GO:0004672
IEA
Genome Projectprotein kinase activity
GO:0004713
ISO
IEA
Genome Projectprotein tyrosine kinase activity
GO:0004714
IEA
Genome Projecttransmembrane receptor protein tyrosine kinase activity
GO:0005010
ISO
IEA
Genome Projectinsulin-like growth factor-activated receptor activity
GO:0005158
ISO
IEA
Genome Projectinsulin receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005520
ISS, ISO
IEA
Genome Projectinsulin-like growth factor binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0031994
ISO
IEA
Genome Projectinsulin-like growth factor I binding
GO:0042802
ISO
IEA
Genome Projectidentical protein binding
GO:0043548
ISO
IEA
Genome Projectphosphatidylinositol 3-kinase binding
GO:0043559
ISO
IEA
Genome Projectinsulin binding
GO:0043560
ISO
IEA
Genome Projectinsulin receptor substrate binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005886
IDA
Genome Projectplasma membrane
GO:0005901
IEA
Genome Projectcaveola
GO:0016020
ISO
IEA
Genome Projectmembrane
GO:0016021
IDA
IEA
Genome Projectintegral component of membrane
GO:0043005
IEA
Genome Projectneuron projection
GO:0043231
ISO
IEA
Genome Projectintracellular membrane-bounded organelle
GO:0043235
ISO
IEA
Genome Projectreceptor complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000494Receptor L-domain
IPR000719Protein kinase domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002011Tyrosine-protein kinase, receptor class II, conserved site
IPR003961Fibronectin type III
IPR006211Furin-like cysteine-rich domain
IPR006212Furin-like repeat
IPR008266Tyrosine-protein kinase, active site
IPR009030Growth factor receptor cysteine-rich domain
IPR011009Protein kinase-like domain
IPR013783Immunoglobulin-like fold
IPR016246Tyrosine-protein kinase, insulin-like receptor
IPR017441Protein kinase, ATP binding site
IPR020635Tyrosine-protein kinase, catalytic domain

No MapMan annotations defined for this gene.