Gene: ENSMUSG00000005370 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000005370
Transcript Identifier
ENSMUST00000005503
Gene Type
Coding gene
Location
17 : 87975149-87990805 : positive

Family Information

Homologous gene family
HOM03P000085
(313 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P001033
(41 genes in 38 species)
specific family

Descriptions

gene_descr
mutS homolog 6 (E. coli)

Identifiers

Type Value
UniprotP54276
MGI1343961

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000710
IBA
Genome Projectmeiotic mismatch repair
GO:0006281
ISO
IEA
Genome ProjectDNA repair
GO:0006298
IMP, IGI
ISO
IEA
Genome Projectmismatch repair
GO:0006974
IEA
Genome Projectcellular response to DNA damage stimulus
GO:0007131
IBA
Genome Projectreciprocal meiotic recombination
GO:0008340
IMP
Genome Projectdetermination of adult lifespan
GO:0008630
IMP
Genome Projectintrinsic apoptotic signaling pathway in response to DNA damage
GO:0009411
IMP
Genome Projectresponse to UV
GO:0016446
IMP
Genome Projectsomatic hypermutation of immunoglobulin genes
GO:0016447
IMP
Genome Projectsomatic recombination of immunoglobulin gene segments
GO:0043570
IBA
Genome Projectmaintenance of DNA repeat elements
GO:0045190
IMP
Genome Projectisotype switching
GO:0045830
IGI
Genome Projectpositive regulation of isotype switching
GO:0045910
IMP
ISO
IEA
Genome Projectnegative regulation of DNA recombination
GO:0051096
ISO
IEA
Genome Projectpositive regulation of helicase activity
GO:0097193
IMP
Genome Projectintrinsic apoptotic signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0000287
ISO
IEA
Genome Projectmagnesium ion binding
GO:0000400
ISO, IBA
IEA
Genome Projectfour-way junction DNA binding
GO:0003677
IMP, IGI
IEA
Genome ProjectDNA binding
GO:0003682
IDA
Genome Projectchromatin binding
GO:0003684
IMP, IGI
Genome Projectdamaged DNA binding
GO:0003690
ISO
IEA
Genome Projectdouble-stranded DNA binding
GO:0005524
ISO
IEA
Genome ProjectATP binding
GO:0008094
IBA
Genome ProjectDNA-dependent ATPase activity
GO:0016887
ISO
IEA
Genome ProjectATPase activity
GO:0030983
ISS, ISO
IEA
Genome Projectmismatched DNA binding
GO:0032137
IDA
ISO
IEA
Genome Projectguanine/thymine mispair binding
GO:0032138
IBA
Genome Projectsingle base insertion or deletion binding
GO:0032142
ISO
IEA
Genome Projectsingle guanine insertion binding
GO:0032143
ISO
IEA
Genome Projectsingle thymine insertion binding
GO:0032357
ISO
IEA
Genome Projectoxidized purine DNA binding
GO:0032405
ISO
IEA
Genome ProjectMutLalpha complex binding
GO:0035064
ISS, ISO
IEA
Genome Projectmethylated histone binding
GO:0043531
ISO
IEA
Genome ProjectADP binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000228
IBA
Genome Projectnuclear chromosome
GO:0000790
IDA
Genome Projectnuclear chromatin
GO:0005634
IEA
Genome Projectnucleus
GO:0005654
ISO
IEA
Genome Projectnucleoplasm
GO:0005694
IEA
Genome Projectchromosome
GO:0005737
ISO
IEA
Genome Projectcytoplasm
GO:0005794
ISO
IEA
Genome ProjectGolgi apparatus
GO:0005886
ISO
IEA
Genome Projectplasma membrane
GO:0032301
IDA
ISO
IEA
Genome ProjectMutSalpha complex
GO:0043231
ISO
IEA
Genome Projectintracellular membrane-bounded organelle

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000313PWWP domain
IPR000432DNA mismatch repair protein MutS, C-terminal
IPR007695DNA mismatch repair protein MutS-like, N-terminal
IPR007696DNA mismatch repair protein MutS, core
IPR007860DNA mismatch repair protein MutS, connector domain
IPR007861DNA mismatch repair protein MutS, clamp
IPR016151DNA mismatch repair protein MutS, N-terminal
IPR027417P-loop containing nucleoside triphosphate hydrolase

No MapMan annotations defined for this gene.