Gene: ENSMUSG00000004936 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000004936
Transcript Identifier
ENSMUST00000005066
Gene Type
Coding gene
Location
9 : 64186685-64253292 : negative

Family Information

Homologous gene family
HOM03P000001
(4368 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P001780
(35 genes in 24 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
mitogen-activated protein kinase kinase 1

Identifiers

Type Value
UniprotP31938
UniprotQ3TMJ8
MGI1346866

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000165
IEA
Genome ProjectMAPK cascade
GO:0000187
IMP
ISO
TAS, IEA
Genome Projectactivation of MAPK activity
GO:0001932
IGI
Genome Projectregulation of protein phosphorylation
GO:0003056
IEA
Genome Projectregulation of vascular smooth muscle contraction
GO:0006468
IMP
IEA
Genome Projectprotein phosphorylation
GO:0006979
IEA
Genome Projectresponse to oxidative stress
GO:0007050
ISO
IEA
Genome Projectcell cycle arrest
GO:0007067
IEA
Genome Projectmitotic nuclear division
GO:0008283
IEA
Genome Projectcell proliferation
GO:0008285
ISO
IEA
Genome Projectnegative regulation of cell proliferation
GO:0010628
ISO
IEA
Genome Projectpositive regulation of gene expression
GO:0016310
IEA
Genome Projectphosphorylation
GO:0018108
IEA
Genome Projectpeptidyl-tyrosine phosphorylation
GO:0030182
IMP
IEA
Genome Projectneuron differentiation
GO:0030216
IMP
Genome Projectkeratinocyte differentiation
GO:0030335
IEA
Genome Projectpositive regulation of cell migration
GO:0032402
IEA
Genome Projectmelanosome transport
GO:0032872
TAS
Genome Projectregulation of stress-activated MAPK cascade
GO:0032968
IEA
Genome Projectpositive regulation of transcription elongation from RNA polymerase II promoter
GO:0034111
IEA
Genome Projectnegative regulation of homotypic cell-cell adhesion
GO:0043547
IEA
Genome Projectpositive regulation of GTPase activity
GO:0045597
IDA
Genome Projectpositive regulation of cell differentiation
GO:0046579
ISO
IEA
Genome Projectpositive regulation of Ras protein signal transduction
GO:0047496
IEA
Genome Projectvesicle transport along microtubule
GO:0048313
IEA
Genome ProjectGolgi inheritance
GO:0048678
IEA
Genome Projectresponse to axon injury
GO:0048679
IGI
Genome Projectregulation of axon regeneration
GO:0048812
IEA
Genome Projectneuron projection morphogenesis
GO:0048870
IMP
Genome Projectcell motility
GO:0050772
IGI
Genome Projectpositive regulation of axonogenesis
GO:0051291
IEA
Genome Projectprotein heterooligomerization
GO:0051384
IEA
Genome Projectresponse to glucocorticoid
GO:0060425
IGI
Genome Projectlung morphogenesis
GO:0060440
IGI
Genome Projecttrachea formation
GO:0060502
IGI
Genome Projectepithelial cell proliferation involved in lung morphogenesis
GO:0060674
IMP
Genome Projectplacenta blood vessel development
GO:0060711
IMP
Genome Projectlabyrinthine layer development
GO:0070371
IGI
Genome ProjectERK1 and ERK2 cascade
GO:0071902
ISO
IEA
Genome Projectpositive regulation of protein serine/threonine kinase activity
GO:0090170
TAS
Genome Projectregulation of Golgi inheritance
GO:0090398
ISO
IEA
Genome Projectcellular senescence
GO:0098779
ISO
Genome Projectmitophagy in response to mitochondrial depolarization
GO:1903146
IEA
Genome Projectregulation of mitophagy
GO:2000641
TAS
Genome Projectregulation of early endosome to late endosome transport

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
IEA
Genome Projectprotein kinase activity
GO:0004674
IEA
Genome Projectprotein serine/threonine kinase activity
GO:0004708
IMP
ISO
IEA
Genome ProjectMAP kinase kinase activity
GO:0004712
TAS
Genome Projectprotein serine/threonine/tyrosine kinase activity
GO:0004713
IEA
Genome Projectprotein tyrosine kinase activity
GO:0004728
IMP
Genome Projectreceptor signaling protein tyrosine phosphatase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0008022
ISO
Genome Projectprotein C-terminus binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0017016
IEA
Genome ProjectRas GTPase binding
GO:0019901
IEA
Genome Projectprotein kinase binding
GO:0031435
IEA
Genome Projectmitogen-activated protein kinase kinase kinase binding
GO:0043539
ISO
IEA
Genome Projectprotein serine/threonine kinase activator activity
GO:0047485
ISO
Genome Projectprotein N-terminus binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
TAS, IEA
Genome Projectnucleus
GO:0005737
ISO
IEA
Genome Projectcytoplasm
GO:0005739
TAS
Genome Projectmitochondrion
GO:0005769
TAS
Genome Projectearly endosome
GO:0005770
TAS
Genome Projectlate endosome
GO:0005783
ISO
IEA
Genome Projectendoplasmic reticulum
GO:0005794
TAS, IEA
Genome ProjectGolgi apparatus
GO:0005815
IEA
Genome Projectmicrotubule organizing center
GO:0005829
TAS, IEA
Genome Projectcytosol
GO:0005856
IEA
Genome Projectcytoskeleton
GO:0005874
IEA
Genome Projectmicrotubule
GO:0005886
ISO
IEA
Genome Projectplasma membrane
GO:0005925
TAS
Genome Projectfocal adhesion
GO:0005938
IEA
Genome Projectcell cortex
GO:0030424
IEA
Genome Projectaxon
GO:0030425
IEA
Genome Projectdendrite
GO:0032839
IEA
Genome Projectdendrite cytoplasm
GO:0043204
IEA
Genome Projectperikaryon
GO:0048471
IEA
Genome Projectperinuclear region of cytoplasm
GO:0070062
ISO
IEA
Genome Projectextracellular exosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000719Protein kinase domain
IPR002290Serine/threonine/dual specificity protein kinase, catalytic domain
IPR008271Serine/threonine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR017441Protein kinase, ATP binding site

No MapMan annotations defined for this gene.