Gene: ENSMUSG00000004296 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000004296
Transcript Identifier
ENSMUST00000170513
Gene Type
Coding gene
Location
11 : 44404037-44413236 : positive

Family Information

Homologous gene family
HOM03P042531
(2 genes in 2 species)
specific family

Descriptions

gene_descr
interleukin 12b

Identifiers

Type Value
UniprotP43432
UniprotQ3ZAX5
MGI96540

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001916
IDA
Genome Projectpositive regulation of T cell mediated cytotoxicity
GO:0002230
IDA
ISO
Genome Projectpositive regulation of defense response to virus by host
GO:0002323
IEA
Genome Projectnatural killer cell activation involved in immune response
GO:0002827
IDA
ISO
Genome Projectpositive regulation of T-helper 1 type immune response
GO:0002860
ISO
IEA
Genome Projectpositive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0002862
IMP
Genome Projectnegative regulation of inflammatory response to antigenic stimulus
GO:0007050
ISO
IEA
Genome Projectcell cycle arrest
GO:0007166
IDA
Genome Projectcell surface receptor signaling pathway
GO:0010224
ISO
IEA
Genome Projectresponse to UV-B
GO:0010535
ISO
IEA
Genome Projectpositive regulation of activation of JAK2 kinase activity
GO:0016477
ISO
IEA
Genome Projectcell migration
GO:0019221
IEA
Genome Projectcytokine-mediated signaling pathway
GO:0019233
IEA
Genome Projectsensory perception of pain
GO:0030101
ISS, ISO
IEA
Genome Projectnatural killer cell activation
GO:0032693
ISO
IEA
Genome Projectnegative regulation of interleukin-10 production
GO:0032700
ISO
IEA
Genome Projectnegative regulation of interleukin-17 production
GO:0032725
ISO
IEA
Genome Projectpositive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729
IMP, IGI
ISO
IEA
Genome Projectpositive regulation of interferon-gamma production
GO:0032733
ISO
IEA
Genome Projectpositive regulation of interleukin-10 production
GO:0032735
ISO
IEA
Genome Projectpositive regulation of interleukin-12 production
GO:0032740
ISO
IEA
Genome Projectpositive regulation of interleukin-17 production
GO:0032760
ISO
IEA
Genome Projectpositive regulation of tumor necrosis factor production
GO:0032816
ISO, IBA
IEA
Genome Projectpositive regulation of natural killer cell activation
GO:0032819
ISO
IEA
Genome Projectpositive regulation of natural killer cell proliferation
GO:0032946
ISO
IEA
Genome Projectpositive regulation of mononuclear cell proliferation
GO:0034393
ISO
IEA
Genome Projectpositive regulation of smooth muscle cell apoptotic process
GO:0042093
ISS, ISO
IEA
Genome ProjectT-helper cell differentiation
GO:0042102
IDA
ISO
IEA
Genome Projectpositive regulation of T cell proliferation
GO:0042104
ISS, ISO
IEA
Genome Projectpositive regulation of activated T cell proliferation
GO:0042510
ISO
IEA
Genome Projectregulation of tyrosine phosphorylation of Stat1 protein
GO:0042517
ISO
IEA
Genome Projectpositive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042520
ISO
IEA
Genome Projectpositive regulation of tyrosine phosphorylation of Stat4 protein
GO:0042523
ISO
IEA
Genome Projectpositive regulation of tyrosine phosphorylation of Stat5 protein
GO:0042832
IMP, IGI
Genome Projectdefense response to protozoan
GO:0044130
IMP
Genome Projectnegative regulation of growth of symbiont in host
GO:0045078
IBA
Genome Projectpositive regulation of interferon-gamma biosynthetic process
GO:0045672
ISO
IEA
Genome Projectpositive regulation of osteoclast differentiation
GO:0045785
ISO
IEA
Genome Projectpositive regulation of cell adhesion
GO:0048662
ISO
IEA
Genome Projectnegative regulation of smooth muscle cell proliferation
GO:0050671
ISO
IEA
Genome Projectpositive regulation of lymphocyte proliferation
GO:0050829
ISO
IEA
Genome Projectdefense response to Gram-negative bacterium
GO:0051135
ISO, IBA
IEA
Genome Projectpositive regulation of NK T cell activation
GO:0051142
ISO
IEA
Genome Projectpositive regulation of NK T cell proliferation
GO:0051607
IDA
Genome Projectdefense response to virus
GO:0071222
IDA
Genome Projectcellular response to lipopolysaccharide
GO:0071346
IDA
Genome Projectcellular response to interferon-gamma

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004896
IEA
Genome Projectcytokine receptor activity
GO:0005125
IDA
ISO
IEA
Genome Projectcytokine activity
GO:0005143
IBA
Genome Projectinterleukin-12 receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008083
ISO, IBA
IEA
Genome Projectgrowth factor activity
GO:0042164
IPI
ISO
IEA
Genome Projectinterleukin-12 alpha subunit binding
GO:0042802
ISO
IEA
Genome Projectidentical protein binding
GO:0042803
IDA
Genome Projectprotein homodimerization activity
GO:0045519
ISO, IBA
IEA
Genome Projectinterleukin-23 receptor binding
GO:0046982
ISO
IEA
Genome Projectprotein heterodimerization activity
GO:0005126
IPI
Genome Projectcytokine receptor binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
IEA
Genome Projectextracellular region
GO:0005615
IDA
IEA
Genome Projectextracellular space
GO:0005737
IDA
Genome Projectcytoplasm
GO:0016020
IEA
Genome Projectmembrane
GO:0043514
IDA, IGI
ISO
IEA
Genome Projectinterleukin-12 complex
GO:0070743
IDA
ISO
IEA
Genome Projectinterleukin-23 complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR003530Long hematopoietin receptor, soluble alpha chain, conserved site
IPR003598Immunoglobulin subtype 2
IPR003961Fibronectin type III
IPR007110Immunoglobulin-like domain
IPR013783Immunoglobulin-like fold
IPR015528Interleukin-12 beta
IPR019482Interleukin-12 beta, central domain

No MapMan annotations defined for this gene.