Gene: ENSMUSG00000004266 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000004266
Transcript Identifier
ENSMUST00000171549
Gene Type
Coding gene
Location
6 : 124721108-124738512 : negative

Family Information

Homologous gene family
HOM03P000197
(172 genes in 24 species)
specific family
Orthologous gene family
ORTHO03P014795
(6 genes in 5 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
protein tyrosine phosphatase, non-receptor type 6

Identifiers

Type Value
UniprotP29351
UniprotQ3UCJ0
MGI96055

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0002244
IMP
Genome Projecthematopoietic progenitor cell differentiation
GO:0002924
IMP
Genome Projectnegative regulation of humoral immune response mediated by circulating immunoglobulin
GO:0006470
IDA, IMP
ISO
IEA
Genome Projectprotein dephosphorylation
GO:0008283
ISS, ISO
IEA
Genome Projectcell proliferation
GO:0008284
ISO
IEA
Genome Projectpositive regulation of cell proliferation
GO:0014068
ISO
IEA
Genome Projectpositive regulation of phosphatidylinositol 3-kinase signaling
GO:0016311
IEA
Genome Projectdephosphorylation
GO:0018108
ISO
IEA
Genome Projectpeptidyl-tyrosine phosphorylation
GO:0019221
TAS
Genome Projectcytokine-mediated signaling pathway
GO:0030154
ISS, ISO
IEA
Genome Projectcell differentiation
GO:0030220
IGI
Genome Projectplatelet formation
GO:0033277
IMP
Genome Projectabortive mitotic cell cycle
GO:0033630
IMP
Genome Projectpositive regulation of cell adhesion mediated by integrin
GO:0035335
ISO
Genome Projectpeptidyl-tyrosine dephosphorylation
GO:0035556
IDA
Genome Projectintracellular signal transduction
GO:0035855
IMP
Genome Projectmegakaryocyte development
GO:0042130
IMP
Genome Projectnegative regulation of T cell proliferation
GO:0042267
IMP
Genome Projectnatural killer cell mediated cytotoxicity
GO:0043407
IMP
Genome Projectnegative regulation of MAP kinase activity
GO:0043409
IMP
Genome Projectnegative regulation of MAPK cascade
GO:0045577
IMP
Genome Projectregulation of B cell differentiation
GO:0050732
IMP
ISO
IEA
Genome Projectnegative regulation of peptidyl-tyrosine phosphorylation
GO:0050853
IMP
Genome ProjectB cell receptor signaling pathway
GO:0050859
IGI
Genome Projectnegative regulation of B cell receptor signaling pathway
GO:0050860
IMP
Genome Projectnegative regulation of T cell receptor signaling pathway
GO:0051279
IGI
Genome Projectregulation of release of sequestered calcium ion into cytosol
GO:0070372
ISS, ISO
IEA
Genome Projectregulation of ERK1 and ERK2 cascade
GO:0070527
IMP
Genome Projectplatelet aggregation
GO:2000045
ISO
IEA
Genome Projectregulation of G1/S transition of mitotic cell cycle

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001784
IPI
Genome Projectphosphotyrosine binding
GO:0004721
IEA
Genome Projectphosphoprotein phosphatase activity
GO:0004725
IDA
TAS, IEA
Genome Projectprotein tyrosine phosphatase activity
GO:0005001
ISS, ISO
IEA
Genome Projecttransmembrane receptor protein tyrosine phosphatase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0016787
IEA
Genome Projecthydrolase activity
GO:0016791
IEA
Genome Projectphosphatase activity
GO:0017124
IDA
Genome ProjectSH3 domain binding
GO:0019901
ISO
IEA
Genome Projectprotein kinase binding
GO:0042169
IDA
Genome ProjectSH2 domain binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
ISO
IEA
Genome Projectnucleus
GO:0005730
ISO
IEA
Genome Projectnucleolus
GO:0005737
ISO
TAS, IEA
Genome Projectcytoplasm
GO:0005829
TAS
Genome Projectcytosol
GO:0005911
IDA
Genome Projectcell-cell junction
GO:0042105
IDA
Genome Projectalpha-beta T cell receptor complex
GO:0070062
ISO
IEA
Genome Projectextracellular exosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000242PTP type protein phosphatase
IPR000387Tyrosine specific protein phosphatases domain
IPR000980SH2 domain
IPR012152Protein-tyrosine phosphatase, non-receptor type-6, -11
IPR016130Protein-tyrosine phosphatase, active site
IPR029021Protein-tyrosine phosphatase-like

No MapMan annotations defined for this gene.