Gene: ENSMUSG00000003873 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000003873
Transcript Identifier
ENSMUST00000033093
Gene Type
Coding gene
Location
7 : 45461862-45466775 : negative

Family Information

Homologous gene family
HOM03P034516
(2 genes in 2 species)
specific family

Descriptions

gene_descr
BCL2-associated X protein

Identifiers

Type Value
UniprotQ07813
UniprotQ544Z6
MGI99702

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001541
IMP, IGI
IEA
Genome Projectovarian follicle development
GO:0001764
IMP
Genome Projectneuron migration
GO:0001776
IGI
Genome Projectleukocyte homeostasis
GO:0001777
IMP
Genome ProjectT cell homeostatic proliferation
GO:0001782
IMP, IGI
Genome ProjectB cell homeostasis
GO:0001783
IGI
ISO
IEA
Genome ProjectB cell apoptotic process
GO:0001822
IGI
Genome Projectkidney development
GO:0001836
IDA, IGI
ISO
IEA
Genome Projectrelease of cytochrome c from mitochondria
GO:0001844
IMP
Genome Projectprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0001974
IGI
Genome Projectblood vessel remodeling
GO:0002262
IGI
Genome Projectmyeloid cell homeostasis
GO:0002352
IGI
Genome ProjectB cell negative selection
GO:0002358
IMP
Genome ProjectB cell homeostatic proliferation
GO:0002904
IGI
Genome Projectpositive regulation of B cell apoptotic process
GO:0006687
IMP
Genome Projectglycosphingolipid metabolic process
GO:0006808
IGI
Genome Projectregulation of nitrogen utilization
GO:0006915
IDA, IMP
ISO
IEA
Genome Projectapoptotic process
GO:0006919
IDA, IMP, IGI
ISO
IEA
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006927
ISS, ISO
IEA
Genome Projecttransformed cell apoptotic process
GO:0006974
IMP
Genome Projectcellular response to DNA damage stimulus
GO:0007007
IEA
Genome Projectinner mitochondrial membrane organization
GO:0007008
IEA
Genome Projectouter mitochondrial membrane organization
GO:0007281
IGI
Genome Projectgerm cell development
GO:0007283
IMP, IGI
Genome Projectspermatogenesis
GO:0007399
IMP
Genome Projectnervous system development
GO:0007420
IEA
Genome Projectbrain development
GO:0007548
IMP
Genome Projectsex differentiation
GO:0008053
IGI
ISS, ISO
IEA
Genome Projectmitochondrial fusion
GO:0008283
IDA, IGI
Genome Projectcell proliferation
GO:0008285
IMP
Genome Projectnegative regulation of cell proliferation
GO:0008584
IMP, IGI
Genome Projectmale gonad development
GO:0008625
IDA
Genome Projectextrinsic apoptotic signaling pathway via death domain receptors
GO:0008630
IMP, IGI
Genome Projectintrinsic apoptotic signaling pathway in response to DNA damage
GO:0008635
IDA, IMP
ISO
IEA
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0008637
IDA
ISO
IEA
Genome Projectapoptotic mitochondrial changes
GO:0009566
IGI
Genome Projectfertilization
GO:0009611
IMP
Genome Projectresponse to wounding
GO:0009636
IMP
ISO
IEA
Genome Projectresponse to toxic substance
GO:0009651
IGI
Genome Projectresponse to salt stress
GO:0009791
IGI
Genome Projectpost-embryonic development
GO:0010212
IMP, IGI
Genome Projectresponse to ionizing radiation
GO:0010248
ISS, ISO
IEA
Genome Projectestablishment or maintenance of transmembrane electrochemical gradient
GO:0010332
IMP
Genome Projectresponse to gamma radiation
GO:0010524
IGI
Genome Projectpositive regulation of calcium ion transport into cytosol
GO:0021854
IMP
Genome Projecthypothalamus development
GO:0021987
IMP
Genome Projectcerebral cortex development
GO:0032091
ISS, ISO
IEA
Genome Projectnegative regulation of protein binding
GO:0032461
ISS, ISO
IEA
Genome Projectpositive regulation of protein oligomerization
GO:0032471
IGI
Genome Projectnegative regulation of endoplasmic reticulum calcium ion concentration
GO:0032976
ISS, ISO
IEA
Genome Projectrelease of matrix enzymes from mitochondria
GO:0033137
IGI
Genome Projectnegative regulation of peptidyl-serine phosphorylation
GO:0033599
IMP
Genome Projectregulation of mammary gland epithelial cell proliferation
GO:0034349
IEA
Genome Projectglial cell apoptotic process
GO:0034644
IGI
Genome Projectcellular response to UV
GO:0035108
IGI
Genome Projectlimb morphogenesis
GO:0035234
IMP, IGI
Genome Projectectopic germ cell programmed cell death
GO:0042220
IEA
Genome Projectresponse to cocaine
GO:0042475
IGI
Genome Projectodontogenesis of dentin-containing tooth
GO:0042493
IEA
Genome Projectresponse to drug
GO:0042981
IEA
Genome Projectregulation of apoptotic process
GO:0043065
IDA, IMP, IGI
ISO
IEA
Genome Projectpositive regulation of apoptotic process
GO:0043281
IMP
Genome Projectregulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043496
ISS, ISO
IEA
Genome Projectregulation of protein homodimerization activity
GO:0043497
ISO
IEA
Genome Projectregulation of protein heterodimerization activity
GO:0043523
IMP
Genome Projectregulation of neuron apoptotic process
GO:0043524
IDA
Genome Projectnegative regulation of neuron apoptotic process
GO:0043525
IMP, IGI
ISO
IEA
Genome Projectpositive regulation of neuron apoptotic process
GO:0043653
ISS, ISO
IEA
Genome Projectmitochondrial fragmentation involved in apoptotic process
GO:0045136
IMP
Genome Projectdevelopment of secondary sexual characteristics
GO:0045333
IEA
Genome Projectcellular respiration
GO:0046666
IMP
Genome Projectretinal cell programmed cell death
GO:0046688
IEA
Genome Projectresponse to copper ion
GO:0048087
IGI
Genome Projectpositive regulation of developmental pigmentation
GO:0048147
IMP
Genome Projectnegative regulation of fibroblast proliferation
GO:0048515
IMP
Genome Projectspermatid differentiation
GO:0048597
IGI
Genome Projectpost-embryonic camera-type eye morphogenesis
GO:0048678
IMP
Genome Projectresponse to axon injury
GO:0048872
IMP, IGI
Genome Projecthomeostasis of number of cells
GO:0048873
IMP
Genome Projecthomeostasis of number of cells within a tissue
GO:0051259
ISO
IEA
Genome Projectprotein oligomerization
GO:0051260
IDA
ISO
IEA
Genome Projectprotein homooligomerization
GO:0051281
IMP
Genome Projectpositive regulation of release of sequestered calcium ion into cytosol
GO:0051402
IMP, IGI
Genome Projectneuron apoptotic process
GO:0051412
IEA
Genome Projectresponse to corticosterone
GO:0051726
IGI
Genome Projectregulation of cell cycle
GO:0060011
IGI
Genome ProjectSertoli cell proliferation
GO:0060041
IMP
Genome Projectretina development in camera-type eye
GO:0060058
IMP
Genome Projectpositive regulation of apoptotic process involved in mammary gland involution
GO:0060068
IGI
Genome Projectvagina development
GO:0070059
IGI
ISO
IEA
Genome Projectintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070242
IGI
Genome Projectthymocyte apoptotic process
GO:0070584
IGI
Genome Projectmitochondrion morphogenesis
GO:0071310
IDA
Genome Projectcellular response to organic substance
GO:0072332
IMP
Genome Projectintrinsic apoptotic signaling pathway by p53 class mediator
GO:0090200
ISS, ISO
IEA
Genome Projectpositive regulation of release of cytochrome c from mitochondria
GO:0097190
IMP
ISO
IEA
Genome Projectapoptotic signaling pathway
GO:0097191
ISO
IEA
Genome Projectextrinsic apoptotic signaling pathway
GO:0097192
IGI
Genome Projectextrinsic apoptotic signaling pathway in absence of ligand
GO:0097193
ISO
IEA
Genome Projectintrinsic apoptotic signaling pathway
GO:0097296
IMP
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:1900103
ISS, ISO
IEA
Genome Projectpositive regulation of endoplasmic reticulum unfolded protein response
GO:1902108
IGI
Genome Projectregulation of mitochondrial membrane permeability involved in apoptotic process
GO:1902110
IGI
Genome Projectpositive regulation of mitochondrial membrane permeability involved in apoptotic process
GO:1902262
IGI
Genome Projectapoptotic process involved in patterning of blood vessels
GO:1902263
IGI
Genome Projectapoptotic process involved in embryonic digit morphogenesis
GO:1902445
IMP
Genome Projectregulation of mitochondrial membrane permeability involved in programmed necrotic cell death
GO:1902512
ISO
IEA
Genome Projectpositive regulation of apoptotic DNA fragmentation
GO:1990009
ISS, ISO
IEA
Genome Projectretinal cell apoptotic process
GO:1990117
ISO
IEA
Genome ProjectB cell receptor apoptotic signaling pathway
GO:2001234
IGI
Genome Projectnegative regulation of apoptotic signaling pathway
GO:2001241
IDA
Genome Projectpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001244
IMP
ISS, ISO
IEA
Genome Projectpositive regulation of intrinsic apoptotic signaling pathway
GO:0051881
IDA
Genome Projectregulation of mitochondrial membrane potential

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005515
IPI
Genome Projectprotein binding
GO:0008289
ISS, ISO
IEA
Genome Projectlipid binding
GO:0015267
ISS, ISO, IBA
IEA
Genome Projectchannel activity
GO:0031072
IEA
Genome Projectheat shock protein binding
GO:0032403
IEA
Genome Projectprotein complex binding
GO:0042802
ISO
IEA
Genome Projectidentical protein binding
GO:0042803
IPI, IMP
ISO
IEA
Genome Projectprotein homodimerization activity
GO:0046982
IPI
ISO
IEA
Genome Projectprotein heterodimerization activity
GO:0051087
IEA
Genome Projectchaperone binding
GO:0051400
IEA
Genome ProjectBH domain binding
GO:0051434
ISO
IEA
Genome ProjectBH3 domain binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005622
IDA
Genome Projectintracellular
GO:0005634
ISS, ISO
IEA
Genome Projectnucleus
GO:0005635
ISO
IEA
Genome Projectnuclear envelope
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005739
IDA
ISO
IEA
Genome Projectmitochondrion
GO:0005741
IDA
IEA
Genome Projectmitochondrial outer membrane
GO:0005757
ISS, ISO
IEA
Genome Projectmitochondrial permeability transition pore complex
GO:0005783
IDA
ISO
IEA
Genome Projectendoplasmic reticulum
GO:0005789
ISS, ISO
IEA
Genome Projectendoplasmic reticulum membrane
GO:0005829
IDA
ISO
IEA
Genome Projectcytosol
GO:0016020
ISO
IEA
Genome Projectmembrane
GO:0016021
ISS
IEA
Genome Projectintegral component of membrane
GO:0031966
IDA
IEA
Genome Projectmitochondrial membrane
GO:0046930
ISS, ISO
IEA
Genome Projectpore complex
GO:0070062
ISO
IEA
Genome Projectextracellular exosome
GO:0097136
ISS, ISO
IEA
Genome ProjectBcl-2 family protein complex
GO:0097144
IPI
ISS, ISO
IEA
Genome ProjectBAX complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR002475Bcl2-like
IPR020717Apoptosis regulator, Bcl-2, BH1 motif, conserved site
IPR020726Apoptosis regulator, Bcl-2, BH2 motif, conserved site
IPR020728Apoptosis regulator, Bcl-2, BH3 motif, conserved site
IPR026298Blc2 family
IPR026304Apoptosis regulator BAX

No MapMan annotations defined for this gene.