Gene: ENSMUSG00000002985 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000002985
Transcript Identifier
ENSMUST00000003066
Gene Type
Coding gene
Location
7 : 19696380-19698230 : negative

Family Information

Homologous gene family
HOM03P039089
(2 genes in 2 species)
specific family

Descriptions

gene_descr
apolipoprotein E

Identifiers

Type Value
UniprotP08226
UniprotQ3TXU4
MGI88057

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001937
ISO
IEA
Genome Projectnegative regulation of endothelial cell proliferation
GO:0002021
IMP
Genome Projectresponse to dietary excess
GO:0006629
IGI
Genome Projectlipid metabolic process
GO:0006641
ISO
IEA
Genome Projecttriglyceride metabolic process
GO:0006695
IBA
Genome Projectcholesterol biosynthetic process
GO:0006707
IMP
Genome Projectcholesterol catabolic process
GO:0006810
IEA
Genome Projecttransport
GO:0006869
IEA
Genome Projectlipid transport
GO:0006874
IDA
Genome Projectcellular calcium ion homeostasis
GO:0006898
ISO
IEA
Genome Projectreceptor-mediated endocytosis
GO:0006979
IMP
Genome Projectresponse to oxidative stress
GO:0007186
ISO
IEA
Genome ProjectG-protein coupled receptor signaling pathway
GO:0007263
ISO
IEA
Genome Projectnitric oxide mediated signal transduction
GO:0008203
IMP
ISO
IEA
Genome Projectcholesterol metabolic process
GO:0010468
IMP
Genome Projectregulation of gene expression
GO:0010544
ISO
IEA
Genome Projectnegative regulation of platelet activation
GO:0010873
IMP
ISO
IEA
Genome Projectpositive regulation of cholesterol esterification
GO:0010875
ISO
IEA
Genome Projectpositive regulation of cholesterol efflux
GO:0015909
ISO
IEA
Genome Projectlong-chain fatty acid transport
GO:0017038
ISO
Genome Projectprotein import
GO:0019068
ISO
IEA
Genome Projectvirion assembly
GO:0019433
IBA
Genome Projecttriglyceride catabolic process
GO:0019934
ISO
IEA
Genome ProjectcGMP-mediated signaling
GO:0030195
ISO
IEA
Genome Projectnegative regulation of blood coagulation
GO:0030516
IBA
Genome Projectregulation of axon extension
GO:0030828
ISO
IEA
Genome Projectpositive regulation of cGMP biosynthetic process
GO:0032374
IBA
Genome Projectregulation of cholesterol transport
GO:0032489
ISO
IEA
Genome Projectregulation of Cdc42 protein signal transduction
GO:0032805
ISO
IEA
Genome Projectpositive regulation of low-density lipoprotein particle receptor catabolic process
GO:0033344
IDA, IMP
ISO
IEA
Genome Projectcholesterol efflux
GO:0033700
ISO, IBA
IEA
Genome Projectphospholipid efflux
GO:0034372
IMP
ISO
IEA
Genome Projectvery-low-density lipoprotein particle remodeling
GO:0034374
IMP
Genome Projectlow-density lipoprotein particle remodeling
GO:0034375
ISO
IEA
Genome Projecthigh-density lipoprotein particle remodeling
GO:0034380
ISO, IBA
IEA
Genome Projecthigh-density lipoprotein particle assembly
GO:0034382
ISO
IEA
Genome Projectchylomicron remnant clearance
GO:0034384
ISO
IEA
Genome Projecthigh-density lipoprotein particle clearance
GO:0034447
ISO
IEA
Genome Projectvery-low-density lipoprotein particle clearance
GO:0042157
IMP, IGI
IEA
Genome Projectlipoprotein metabolic process
GO:0042158
IGI
Genome Projectlipoprotein biosynthetic process
GO:0042159
IMP
Genome Projectlipoprotein catabolic process
GO:0042311
IMP
Genome Projectvasodilation
GO:0042632
IMP, IGI
ISO
IEA
Genome Projectcholesterol homeostasis
GO:0043407
ISO
IEA
Genome Projectnegative regulation of MAP kinase activity
GO:0043524
IBA
Genome Projectnegative regulation of neuron apoptotic process
GO:0043537
ISO
IEA
Genome Projectnegative regulation of blood vessel endothelial cell migration
GO:0043691
ISO, IBA
IEA
Genome Projectreverse cholesterol transport
GO:0044794
ISO
IEA
Genome Projectpositive regulation by host of viral process
GO:0045541
ISO
IEA
Genome Projectnegative regulation of cholesterol biosynthetic process
GO:0046889
ISO, IBA
IEA
Genome Projectpositive regulation of lipid biosynthetic process
GO:0048844
IGI
Genome Projectartery morphogenesis
GO:0050728
IGI
Genome Projectnegative regulation of inflammatory response
GO:0051000
ISO, IBA
IEA
Genome Projectpositive regulation of nitric-oxide synthase activity
GO:0051044
ISO
IEA
Genome Projectpositive regulation of membrane protein ectodomain proteolysis
GO:0051055
ISO
IEA
Genome Projectnegative regulation of lipid biosynthetic process
GO:0051651
IMP
Genome Projectmaintenance of location in cell
GO:0055088
IMP
Genome Projectlipid homeostasis
GO:0055089
ISO
IEA
Genome Projectfatty acid homeostasis
GO:0060999
ISO
IEA
Genome Projectpositive regulation of dendritic spine development
GO:0061000
ISO
IEA
Genome Projectnegative regulation of dendritic spine development
GO:0072358
IMP
Genome Projectcardiovascular system development
GO:0090370
ISO
IEA
Genome Projectnegative regulation of cholesterol efflux
GO:0097113
ISO
Genome ProjectAMPA glutamate receptor clustering
GO:0097114
ISO
Genome ProjectNMDA glutamate receptor clustering
GO:1900221
ISO, IBA
IEA
Genome Projectregulation of beta-amyloid clearance
GO:1901214
ISO
IEA
Genome Projectregulation of neuron death
GO:1901215
ISO
IEA
Genome Projectnegative regulation of neuron death
GO:1901216
ISO
IEA
Genome Projectpositive regulation of neuron death
GO:1901627
ISO
IEA
Genome Projectnegative regulation of postsynaptic membrane organization
GO:1901628
ISO
IEA
Genome Projectpositive regulation of postsynaptic membrane organization
GO:1901630
ISO
IEA
Genome Projectnegative regulation of presynaptic membrane organization
GO:1901631
ISO
IEA
Genome Projectpositive regulation of presynaptic membrane organization
GO:1902004
ISO
IEA
Genome Projectpositive regulation of beta-amyloid formation
GO:1902430
ISO
IEA
Genome Projectnegative regulation of beta-amyloid formation
GO:1902947
ISO
IEA
Genome Projectregulation of tau-protein kinase activity
GO:1902951
ISO
IEA
Genome Projectnegative regulation of dendritic spine maintenance
GO:1902952
ISO
IEA
Genome Projectpositive regulation of dendritic spine maintenance
GO:1902995
ISO
IEA
Genome Projectpositive regulation of phospholipid efflux
GO:1902998
ISO
IEA
Genome Projectpositive regulation of neurofibrillary tangle assembly
GO:1902999
ISO
IEA
Genome Projectnegative regulation of phospholipid efflux
GO:1903001
ISO
IEA
Genome Projectnegative regulation of lipid transport across blood brain barrier
GO:1903002
ISO
IEA
Genome Projectpositive regulation of lipid transport across blood brain barrier
GO:0008104
IMP
Genome Projectprotein localization
GO:0031103
IGI
Genome Projectaxon regeneration

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001540
ISS, ISO, IBA
IEA
Genome Projectbeta-amyloid binding
GO:0005319
ISO
IEA
Genome Projectlipid transporter activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005543
ISO, IBA
IEA
Genome Projectphospholipid binding
GO:0008201
ISO
IEA
Genome Projectheparin binding
GO:0008289
ISO
IEA
Genome Projectlipid binding
GO:0015485
IBA
Genome Projectcholesterol binding
GO:0016209
ISO
IEA
Genome Projectantioxidant activity
GO:0017127
IDA
Genome Projectcholesterol transporter activity
GO:0042802
ISO
IEA
Genome Projectidentical protein binding
GO:0042803
ISO
IEA
Genome Projectprotein homodimerization activity
GO:0046911
ISO
IEA
Genome Projectmetal chelating activity
GO:0048156
ISO
IEA
Genome Projecttau protein binding
GO:0050750
ISO, IBA
IEA
Genome Projectlow-density lipoprotein particle receptor binding
GO:0060228
IMP
ISO
IEA
Genome Projectphosphatidylcholine-sterol O-acyltransferase activator activity
GO:0070326
ISO, IBA
IEA
Genome Projectvery-low-density lipoprotein particle receptor binding
GO:0071813
IDA
Genome Projectlipoprotein particle binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
TAS, IEA
Genome Projectextracellular region
GO:0005615
IDA
ISO
IEA
Genome Projectextracellular space
GO:0005634
ISO
IEA
Genome Projectnucleus
GO:0005783
ISO
IEA
Genome Projectendoplasmic reticulum
GO:0005794
ISO
IEA
Genome ProjectGolgi apparatus
GO:0005829
TAS
Genome Projectcytosol
GO:0016020
ISO
IEA
Genome Projectmembrane
GO:0031012
ISO
IEA
Genome Projectextracellular matrix
GO:0031982
IEA
Genome Projectvesicle
GO:0034361
ISO
IEA
Genome Projectvery-low-density lipoprotein particle
GO:0034362
IDA
ISO
IEA
Genome Projectlow-density lipoprotein particle
GO:0034363
ISO, IBA
IEA
Genome Projectintermediate-density lipoprotein particle
GO:0034364
ISO, IBA
IEA
Genome Projecthigh-density lipoprotein particle
GO:0042627
ISO, IBA
IEA
Genome Projectchylomicron
GO:0070062
ISO
IEA
Genome Projectextracellular exosome
GO:0072562
ISO, IBA
IEA
Genome Projectblood microparticle
GO:1903561
ISO
Genome Projectextracellular vesicle

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000074Apolipoprotein A/E

No MapMan annotations defined for this gene.