Gene: ENSMUSG00000002633 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000002633
Transcript Identifier
ENSMUST00000002708
Gene Type
Coding gene
Location
5 : 28457855-28466763 : negative

Family Information

Homologous gene family
HOM03P007513
(11 genes in 6 species)
specific family
Orthologous gene family
ORTHO03P067633
(2 genes in 2 species)
specific family

Descriptions

gene_descr
sonic hedgehog

Identifiers

Type Value
UniprotQ62226
MGI98297

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000122
IDA, IMP
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0001525
IDA, IMP, IGI
Genome Projectangiogenesis
GO:0001569
IMP
Genome Projectpatterning of blood vessels
GO:0001570
IDA
Genome Projectvasculogenesis
GO:0001656
IMP
Genome Projectmetanephros development
GO:0001658
IMP
Genome Projectbranching involved in ureteric bud morphogenesis
GO:0001708
IDA, IMP, IGI
Genome Projectcell fate specification
GO:0001755
IMP
Genome Projectneural crest cell migration
GO:0001822
IMP
Genome Projectkidney development
GO:0001942
IMP
Genome Projecthair follicle development
GO:0001944
IMP
Genome Projectvasculature development
GO:0001947
IMP
Genome Projectheart looping
GO:0002052
IDA
Genome Projectpositive regulation of neuroblast proliferation
GO:0002053
IMP
Genome Projectpositive regulation of mesenchymal cell proliferation
GO:0002076
IDA
Genome Projectosteoblast development
GO:0002320
IMP
ISO
IEA
Genome Projectlymphoid progenitor cell differentiation
GO:0003140
IMP
Genome Projectdetermination of left/right asymmetry in lateral mesoderm
GO:0006355
IMP
Genome Projectregulation of transcription, DNA-templated
GO:0006508
IEA
Genome Projectproteolysis
GO:0006897
IDA
Genome Projectendocytosis
GO:0006915
IGI
Genome Projectapoptotic process
GO:0007154
IEA
Genome Projectcell communication
GO:0007165
TAS
Genome Projectsignal transduction
GO:0007224
IDA, IMP, IGI
Genome Projectsmoothened signaling pathway
GO:0007228
IDA, IMP, IGI
Genome Projectpositive regulation of hh target transcription factor activity
GO:0007267
IMP
IEA
Genome Projectcell-cell signaling
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0007368
IMP
Genome Projectdetermination of left/right symmetry
GO:0007389
IMP, IGI
Genome Projectpattern specification process
GO:0007398
IMP
Genome Projectectoderm development
GO:0007405
IDA
Genome Projectneuroblast proliferation
GO:0007411
IDA, IMP
Genome Projectaxon guidance
GO:0007417
IMP
Genome Projectcentral nervous system development
GO:0007442
IMP
Genome Projecthindgut morphogenesis
GO:0007507
IMP
Genome Projectheart development
GO:0007596
IMP
Genome Projectblood coagulation
GO:0008209
IMP
Genome Projectandrogen metabolic process
GO:0008283
IGI
Genome Projectcell proliferation
GO:0008284
IDA, IMP, IGI
ISO
Genome Projectpositive regulation of cell proliferation
GO:0009949
IMP
Genome Projectpolarity specification of anterior/posterior axis
GO:0009952
IMP
Genome Projectanterior/posterior pattern specification
GO:0009953
IGI
Genome Projectdorsal/ventral pattern formation
GO:0010463
IMP
Genome Projectmesenchymal cell proliferation
GO:0010468
IDA, IMP, IGI
ISO
Genome Projectregulation of gene expression
GO:0010628
IMP
Genome Projectpositive regulation of gene expression
GO:0010629
IMP
Genome Projectnegative regulation of gene expression
GO:0014003
IDA
Genome Projectoligodendrocyte development
GO:0014706
IMP
Genome Projectstriated muscle tissue development
GO:0014858
IMP
Genome Projectpositive regulation of skeletal muscle cell proliferation
GO:0014902
IMP
Genome Projectmyotube differentiation
GO:0016539
IEA
Genome Projectintein-mediated protein splicing
GO:0021513
IMP
ISO
Genome Projectspinal cord dorsal/ventral patterning
GO:0021521
ISO
Genome Projectventral spinal cord interneuron specification
GO:0021522
IGI
Genome Projectspinal cord motor neuron differentiation
GO:0021794
IMP, IGI
Genome Projectthalamus development
GO:0021904
IDA, IMP, IGI
Genome Projectdorsal/ventral neural tube patterning
GO:0021930
IGI
Genome Projectcerebellar granule cell precursor proliferation
GO:0021938
IDA, IMP
Genome Projectsmoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
GO:0021940
IDA
Genome Projectpositive regulation of cerebellar granule cell precursor proliferation
GO:0021978
IMP
Genome Projecttelencephalon regionalization
GO:0030010
IDA
Genome Projectestablishment of cell polarity
GO:0030162
IDA
Genome Projectregulation of proteolysis
GO:0030177
IMP
Genome Projectpositive regulation of Wnt signaling pathway
GO:0030178
IDA
Genome Projectnegative regulation of Wnt signaling pathway
GO:0030323
IMP
Genome Projectrespiratory tube development
GO:0030324
IMP, IGI
Genome Projectlung development
GO:0030326
IMP, IGI
Genome Projectembryonic limb morphogenesis
GO:0030336
IDA
Genome Projectnegative regulation of cell migration
GO:0030539
IMP
Genome Projectmale genitalia development
GO:0030850
IMP
Genome Projectprostate gland development
GO:0030878
IMP
Genome Projectthyroid gland development
GO:0030900
IGI
Genome Projectforebrain development
GO:0030901
IGI
Genome Projectmidbrain development
GO:0030902
IMP, IGI
Genome Projecthindbrain development
GO:0031016
IMP, IGI
Genome Projectpancreas development
GO:0031069
IMP
Genome Projecthair follicle morphogenesis
GO:0032435
IMP
Genome Projectnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0033077
IMP
Genome ProjectT cell differentiation in thymus
GO:0033089
IMP
Genome Projectpositive regulation of T cell differentiation in thymus
GO:0033092
IMP
Genome Projectpositive regulation of immature T cell proliferation in thymus
GO:0034244
IDA
Genome Projectnegative regulation of transcription elongation from RNA polymerase II promoter
GO:0034504
IDA
Genome Projectprotein localization to nucleus
GO:0035115
IMP
Genome Projectembryonic forelimb morphogenesis
GO:0035116
IMP
Genome Projectembryonic hindlimb morphogenesis
GO:0042127
IDA
Genome Projectregulation of cell proliferation
GO:0042130
IMP
Genome Projectnegative regulation of T cell proliferation
GO:0042177
IMP
Genome Projectnegative regulation of protein catabolic process
GO:0042307
IGI
Genome Projectpositive regulation of protein import into nucleus
GO:0042475
IMP
Genome Projectodontogenesis of dentin-containing tooth
GO:0042476
IDA
Genome Projectodontogenesis
GO:0042481
IMP
Genome Projectregulation of odontogenesis
GO:0042733
IMP, IGI
Genome Projectembryonic digit morphogenesis
GO:0043010
IDA, IMP, IGI
Genome Projectcamera-type eye development
GO:0043066
IDA, IMP
Genome Projectnegative regulation of apoptotic process
GO:0043369
IMP
ISO
IEA
Genome ProjectCD4-positive or CD8-positive, alpha-beta T cell lineage commitment
GO:0043588
IMP
Genome Projectskin development
GO:0045059
IMP
Genome Projectpositive thymic T cell selection
GO:0045060
IMP
Genome Projectnegative thymic T cell selection
GO:0045109
IMP
Genome Projectintermediate filament organization
GO:0045165
IGI
Genome Projectcell fate commitment
GO:0045445
IDA
Genome Projectmyoblast differentiation
GO:0045596
IDA, IMP
Genome Projectnegative regulation of cell differentiation
GO:0045597
IMP
Genome Projectpositive regulation of cell differentiation
GO:0045880
IMP
ISS, ISO
Genome Projectpositive regulation of smoothened signaling pathway
GO:0045893
IDA
ISO
IEA
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045944
IDA, IMP, IGI
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046638
IMP
Genome Projectpositive regulation of alpha-beta T cell differentiation
GO:0046639
IMP
Genome Projectnegative regulation of alpha-beta T cell differentiation
GO:0048468
IMP
Genome Projectcell development
GO:0048538
IMP
Genome Projectthymus development
GO:0048546
IMP
Genome Projectdigestive tract morphogenesis
GO:0048557
IMP
TAS
Genome Projectembryonic digestive tract morphogenesis
GO:0048568
IMP
Genome Projectembryonic organ development
GO:0048589
IMP
Genome Projectdevelopmental growth
GO:0048598
IMP
Genome Projectembryonic morphogenesis
GO:0048617
IMP
Genome Projectembryonic foregut morphogenesis
GO:0048643
IMP
Genome Projectpositive regulation of skeletal muscle tissue development
GO:0048645
IMP
Genome Projectorgan formation
GO:0048646
IMP
Genome Projectanatomical structure formation involved in morphogenesis
GO:0048663
IMP
Genome Projectneuron fate commitment
GO:0048706
IGI
Genome Projectembryonic skeletal system development
GO:0048709
IGI
Genome Projectoligodendrocyte differentiation
GO:0048714
IDA
Genome Projectpositive regulation of oligodendrocyte differentiation
GO:0048754
IMP
Genome Projectbranching morphogenesis of an epithelial tube
GO:0048839
IMP, IGI
Genome Projectinner ear development
GO:0048856
IMP
Genome Projectanatomical structure development
GO:0048859
IMP
Genome Projectformation of anatomical boundary
GO:0048864
IMP
Genome Projectstem cell development
GO:0051146
IDA, IMP
Genome Projectstriated muscle cell differentiation
GO:0051155
IMP
Genome Projectpositive regulation of striated muscle cell differentiation
GO:0051781
ISO
IEA
Genome Projectpositive regulation of cell division
GO:0060020
IDA
Genome ProjectBergmann glial cell differentiation
GO:0060021
IMP
Genome Projectpalate development
GO:0060070
IDA
Genome Projectcanonical Wnt signaling pathway
GO:0060173
IMP, IGI
Genome Projectlimb development
GO:0060174
IMP
Genome Projectlimb bud formation
GO:0060425
IMP
Genome Projectlung morphogenesis
GO:0060428
IMP
Genome Projectlung epithelium development
GO:0060438
IMP
Genome Projecttrachea development
GO:0060439
IMP
Genome Projecttrachea morphogenesis
GO:0060441
IMP
Genome Projectepithelial tube branching involved in lung morphogenesis
GO:0060442
IDA
Genome Projectbranching involved in prostate gland morphogenesis
GO:0060445
IMP, IGI
Genome Projectbranching involved in salivary gland morphogenesis
GO:0060447
IMP
Genome Projectbud outgrowth involved in lung branching
GO:0060458
IMP
Genome Projectright lung development
GO:0060459
IMP
Genome Projectleft lung development
GO:0060463
IMP
Genome Projectlung lobe morphogenesis
GO:0060484
IMP
Genome Projectlung-associated mesenchyme development
GO:0060516
IDA
Genome Projectprimary prostatic bud elongation
GO:0060523
IDA
Genome Projectprostate epithelial cord elongation
GO:0060662
IDA
Genome Projectsalivary gland cavitation
GO:0060664
IMP
Genome Projectepithelial cell proliferation involved in salivary gland morphogenesis
GO:0060684
IMP
Genome Projectepithelial-mesenchymal cell signaling
GO:0060685
IDA, IMP
Genome Projectregulation of prostatic bud formation
GO:0060738
IGI
ISO
IEA
Genome Projectepithelial-mesenchymal signaling involved in prostate gland development
GO:0060768
IMP
Genome Projectregulation of epithelial cell proliferation involved in prostate gland development
GO:0060769
IMP
Genome Projectpositive regulation of epithelial cell proliferation involved in prostate gland development
GO:0060782
IMP
Genome Projectregulation of mesenchymal cell proliferation involved in prostate gland development
GO:0060783
IMP
Genome Projectmesenchymal smoothened signaling pathway involved in prostate gland development
GO:0060840
IMP, IGI
Genome Projectartery development
GO:0060916
IDA
Genome Projectmesenchymal cell proliferation involved in lung development
GO:0060979
TAS
Genome Projectvasculogenesis involved in coronary vascular morphogenesis
GO:0061053
IMP
Genome Projectsomite development
GO:0061189
ISO
IEA
Genome Projectpositive regulation of sclerotome development
GO:0071285
IDA
Genome Projectcellular response to lithium ion
GO:0072001
IEA
Genome Projectrenal system development
GO:0072136
IMP
Genome Projectmetanephric mesenchymal cell proliferation involved in metanephros development
GO:0080125
IMP
Genome Projectmulticellular structure septum development
GO:0090090
IMP
Genome Projectnegative regulation of canonical Wnt signaling pathway
GO:0090370
IMP
Genome Projectnegative regulation of cholesterol efflux
GO:0097190
IDA
Genome Projectapoptotic signaling pathway
GO:1900180
ISO
IEA
Genome Projectregulation of protein localization to nucleus
GO:2000062
IDA
Genome Projectnegative regulation of ureter smooth muscle cell differentiation
GO:2000063
IMP
Genome Projectpositive regulation of ureter smooth muscle cell differentiation
GO:2000357
IDA
Genome Projectnegative regulation of kidney smooth muscle cell differentiation
GO:2000358
IDA
Genome Projectpositive regulation of kidney smooth muscle cell differentiation
GO:2000729
IMP
Genome Projectpositive regulation of mesenchymal cell proliferation involved in ureter development
GO:2001054
IMP
Genome Projectnegative regulation of mesenchymal cell apoptotic process

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001948
IDA
Genome Projectglycoprotein binding
GO:0005113
IPI
ISO
IEA
Genome Projectpatched binding
GO:0005509
ISS, ISO
IEA
Genome Projectcalcium ion binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005539
IDA
Genome Projectglycosaminoglycan binding
GO:0008270
ISS, ISO
IEA
Genome Projectzinc ion binding
GO:0043237
IDA
Genome Projectlaminin-1 binding
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0016787
IDA
Genome Projecthydrolase activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
TAS, IEA
Genome Projectextracellular region
GO:0005578
IDA
Genome Projectproteinaceous extracellular matrix
GO:0005615
IDA
ISO
IEA
Genome Projectextracellular space
GO:0005634
IDA
Genome Projectnucleus
GO:0005886
TAS, IEA
Genome Projectplasma membrane
GO:0009986
IDA
Genome Projectcell surface
GO:0016020
IDA
IEA
Genome Projectmembrane
GO:0045121
IDA
Genome Projectmembrane raft

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000320Hedgehog, N-terminal signalling domain
IPR001657Hedgehog protein
IPR001767Hedgehog protein, Hint domain
IPR003586Hint domain C-terminal
IPR003587Hint domain N-terminal
IPR006141Intein N-terminal splicing region
IPR009045Hedgehog signalling/DD-peptidase zinc-binding domain
IPR028992Hedgehog/Intein (Hint) domain

No MapMan annotations defined for this gene.