Gene: ENSMUSG00000002496 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000002496
Transcript Identifier
ENSMUST00000097373
Gene Type
Coding gene
Location
17 : 24596605-24632082 : negative

Family Information

Homologous gene family
HOM03P016499
(5 genes in 4 species)
specific family

Descriptions

gene_descr
tuberous sclerosis 2

Identifiers

Type Value
UniprotQ7TT21
MGI102548

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001666
IMP
Genome Projectresponse to hypoxia
GO:0001843
IMP
Genome Projectneural tube closure
GO:0006469
IMP
Genome Projectnegative regulation of protein kinase activity
GO:0006606
IMP
Genome Projectprotein import into nucleus
GO:0007507
IMP
Genome Projectheart development
GO:0008104
IDA
Genome Projectprotein localization
GO:0008285
IMP, IGI
Genome Projectnegative regulation of cell proliferation
GO:0014065
IMP
Genome Projectphosphatidylinositol 3-kinase signaling
GO:0014067
IMP
Genome Projectnegative regulation of phosphatidylinositol 3-kinase signaling
GO:0030030
ISO
Genome Projectcell projection organization
GO:0030100
IMP
Genome Projectregulation of endocytosis
GO:0030178
IBA
Genome Projectnegative regulation of Wnt signaling pathway
GO:0032007
IMP
IEA
Genome Projectnegative regulation of TOR signaling
GO:0032869
IMP
Genome Projectcellular response to insulin stimulus
GO:0043491
IMP, IGI
Genome Projectprotein kinase B signaling
GO:0043547
IBA
IEA
Genome Projectpositive regulation of GTPase activity
GO:0044861
IMP
Genome Projectprotein transport into plasma membrane raft
GO:0045792
ISO
Genome Projectnegative regulation of cell size
GO:0045944
IMP
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046323
IMP
Genome Projectglucose import
GO:0046626
IMP
Genome Projectregulation of insulin receptor signaling pathway
GO:0046627
IBA
Genome Projectnegative regulation of insulin receptor signaling pathway
GO:0048009
IMP, IGI
Genome Projectinsulin-like growth factor receptor signaling pathway
GO:0050918
IMP
Genome Projectpositive chemotaxis
GO:0051056
IEA
Genome Projectregulation of small GTPase mediated signal transduction
GO:0051726
IBA
Genome Projectregulation of cell cycle
GO:0051898
IMP, IGI
Genome Projectnegative regulation of protein kinase B signaling

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005096
ISO, IBA
IEA
Genome ProjectGTPase activator activity
GO:0019902
ISO
IEA
Genome Projectphosphatase binding
GO:0031267
ISO
Genome Projectsmall GTPase binding
GO:0042803
ISO
IEA
Genome Projectprotein homodimerization activity
GO:0071889
IDA
Genome Project14-3-3 protein binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IEA
Genome Projectnucleus
GO:0005737
IDA
ISO
IEA
Genome Projectcytoplasm
GO:0005764
ISO
Genome Projectlysosome
GO:0005794
IEA
Genome ProjectGolgi apparatus
GO:0005829
ISO
IEA
Genome Projectcytosol
GO:0016020
ISO
IEA
Genome Projectmembrane
GO:0033596
ISO, IBA
IEA
Genome ProjectTSC1-TSC2 complex
GO:0048471
ISO
IEA
Genome Projectperinuclear region of cytoplasm

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000331Rap GTPase activating protein domain
IPR003913Tuberin
IPR011989Armadillo-like helical
IPR016024Armadillo-type fold
IPR018515Tuberin-type domain
IPR024584Tuberin, N-terminal

No MapMan annotations defined for this gene.