Gene: ENSMUSG00000001761 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000001761
Transcript Identifier
ENSMUST00000001812
Gene Type
Coding gene
Location
6 : 29736011-29760285 : positive

Family Information

Homologous gene family
HOM03P002165
(40 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P039462
(3 genes in 3 species)
specific family

Descriptions

gene_descr
smoothened homolog (Drosophila)

Identifiers

Type Value
UniprotP56726
UniprotQ4VBD5
MGI108075

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000122
IMP
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0001503
IMP
Genome Projectossification
GO:0001570
IMP
Genome Projectvasculogenesis
GO:0001649
IMP
Genome Projectosteoblast differentiation
GO:0001701
IMP
Genome Projectin utero embryonic development
GO:0001708
IMP
Genome Projectcell fate specification
GO:0001755
IGI
Genome Projectneural crest cell migration
GO:0001947
IMP
Genome Projectheart looping
GO:0002052
IGI
Genome Projectpositive regulation of neuroblast proliferation
GO:0002053
IMP
Genome Projectpositive regulation of mesenchymal cell proliferation
GO:0003007
IGI
Genome Projectheart morphogenesis
GO:0003140
IMP
Genome Projectdetermination of left/right asymmetry in lateral mesoderm
GO:0003323
IMP
Genome Projecttype B pancreatic cell development
GO:0007165
IEA
Genome Projectsignal transduction
GO:0007166
IEA
Genome Projectcell surface receptor signaling pathway
GO:0007186
IBA
IEA
Genome ProjectG-protein coupled receptor signaling pathway
GO:0007224
IMP, IGI
ISO
IEA
Genome Projectsmoothened signaling pathway
GO:0007228
IMP
Genome Projectpositive regulation of hh target transcription factor activity
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0007368
IMP
Genome Projectdetermination of left/right symmetry
GO:0007371
IMP
Genome Projectventral midline determination
GO:0007389
IMP
Genome Projectpattern specification process
GO:0007417
IGI
Genome Projectcentral nervous system development
GO:0007494
IMP
Genome Projectmidgut development
GO:0008284
IMP
Genome Projectpositive regulation of cell proliferation
GO:0009952
IMP
Genome Projectanterior/posterior pattern specification
GO:0009953
IMP
Genome Projectdorsal/ventral pattern formation
GO:0010468
IGI
Genome Projectregulation of gene expression
GO:0010628
IMP
Genome Projectpositive regulation of gene expression
GO:0010629
IMP
Genome Projectnegative regulation of gene expression
GO:0021542
IMP
Genome Projectdentate gyrus development
GO:0021696
IMP
Genome Projectcerebellar cortex morphogenesis
GO:0021794
IMP
Genome Projectthalamus development
GO:0021904
IMP
Genome Projectdorsal/ventral neural tube patterning
GO:0021910
IMP
Genome Projectsmoothened signaling pathway involved in ventral spinal cord patterning
GO:0021938
IMP
Genome Projectsmoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
GO:0021953
IMP
Genome Projectcentral nervous system neuron differentiation
GO:0021987
IMP
Genome Projectcerebral cortex development
GO:0030857
IMP
Genome Projectnegative regulation of epithelial cell differentiation
GO:0031069
IMP
Genome Projecthair follicle morphogenesis
GO:0034504
IMP
Genome Projectprotein localization to nucleus
GO:0035264
IMP, IGI
Genome Projectmulticellular organism growth
GO:0040018
IMP
Genome Projectpositive regulation of multicellular organism growth
GO:0042307
IGI
Genome Projectpositive regulation of protein import into nucleus
GO:0042475
IMP
Genome Projectodontogenesis of dentin-containing tooth
GO:0043066
IMP
Genome Projectnegative regulation of apoptotic process
GO:0043392
IMP, IGI
Genome Projectnegative regulation of DNA binding
GO:0045880
IMP
Genome Projectpositive regulation of smoothened signaling pathway
GO:0045892
IMP
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045893
IMP
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045944
IMP
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046622
IMP
Genome Projectpositive regulation of organ growth
GO:0048143
IMP
Genome Projectastrocyte activation
GO:0048468
IMP
Genome Projectcell development
GO:0048565
IMP
Genome Projectdigestive tract development
GO:0048568
IGI
Genome Projectembryonic organ development
GO:0048589
IMP
Genome Projectdevelopmental growth
GO:0048741
IMP
Genome Projectskeletal muscle fiber development
GO:0048853
IMP
Genome Projectforebrain morphogenesis
GO:0048873
IDA
Genome Projecthomeostasis of number of cells within a tissue
GO:0050679
IMP
Genome Projectpositive regulation of epithelial cell proliferation
GO:0050821
IDA
Genome Projectprotein stabilization
GO:0051451
IGI
Genome Projectmyoblast migration
GO:0051799
IMP
Genome Projectnegative regulation of hair follicle development
GO:0060248
ISS, ISO
IEA
Genome Projectdetection of cell density by contact stimulus involved in contact inhibition
GO:0060413
IGI
Genome Projectatrial septum morphogenesis
GO:0060644
IMP
Genome Projectmammary gland epithelial cell differentiation
GO:0060684
IMP
Genome Projectepithelial-mesenchymal cell signaling
GO:0061053
IMP
Genome Projectsomite development
GO:0061113
IMP
Genome Projectpancreas morphogenesis
GO:0070986
IMP
Genome Projectleft/right axis specification
GO:0071397
IEP
Genome Projectcellular response to cholesterol
GO:0072001
IEA
Genome Projectrenal system development
GO:0072285
IMP
Genome Projectmesenchymal to epithelial transition involved in metanephric renal vesicle formation
GO:0090190
IMP
Genome Projectpositive regulation of branching involved in ureteric bud morphogenesis
GO:2000036
IMP
Genome Projectregulation of stem cell population maintenance
GO:2000826
IMP
Genome Projectregulation of heart morphogenesis
GO:0035567
IBA
Genome Projectnon-canonical Wnt signaling pathway
GO:0060070
IBA
Genome Projectcanonical Wnt signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004871
IEA
Genome Projectsignal transducer activity
GO:0004888
IEA
Genome Projecttransmembrane signaling receptor activity
GO:0004930
IBA
IEA
Genome ProjectG-protein coupled receptor activity
GO:0005113
ISO, IBA
IEA
Genome Projectpatched binding
GO:0008144
IDA
ISO
IEA
Genome Projectdrug binding
GO:0017147
IBA
Genome ProjectWnt-protein binding
GO:0042813
IBA
Genome ProjectWnt-activated receptor activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005794
ISO
IEA
Genome ProjectGolgi apparatus
GO:0005886
IDA
ISS, ISO
IEA
Genome Projectplasma membrane
GO:0005901
ISO
IEA
Genome Projectcaveola
GO:0005929
IDA
IEA
Genome Projectcilium
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IBA
IEA
Genome Projectintegral component of membrane
GO:0030666
TAS
Genome Projectendocytic vesicle membrane
GO:0042995
IEA
Genome Projectcell projection
GO:0043231
ISO
IEA
Genome Projectintracellular membrane-bounded organelle
GO:0060170
IDA
TAS
Genome Projectciliary membrane
GO:0070062
ISO
IEA
Genome Projectextracellular exosome
GO:0072372
IDA
Genome Projectprimary cilium

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000539Frizzled protein
IPR015526Frizzled/secreted frizzled-related protein
IPR017981GPCR, family 2-like
IPR020067Frizzled domain
IPR026544Smoothened

No MapMan annotations defined for this gene.