Gene: ENSMUSG00000001131 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000001131
Transcript Identifier
ENSMUST00000009530
Gene Type
Coding gene
Location
X : 20871039-20874632 : positive

Family Information

Homologous gene family
HOM03P008198
(10 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P070969
(2 genes in 2 species)
specific family

Descriptions

gene_descr
tissue inhibitor of metalloproteinase 1

Identifiers

Type Value
UniprotP12032
MGI98752

Toolbox

Explore

Create

View

Browse

 

Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001775
IEA
Genome Projectcell activation
GO:0007568
IEA
Genome Projectaging
GO:0008284
ISS, ISO
IEA
Genome Projectpositive regulation of cell proliferation
GO:0009725
IBA
Genome Projectresponse to hormone
GO:0010033
IEA
Genome Projectresponse to organic substance
GO:0010466
IEA
Genome Projectnegative regulation of peptidase activity
GO:0010951
ISS, ISO, IBA
IEA
Genome Projectnegative regulation of endopeptidase activity
GO:0034097
IBA
IEA
Genome Projectresponse to cytokine
GO:0042060
IEA
Genome Projectwound healing
GO:0043066
IEA
Genome Projectnegative regulation of apoptotic process
GO:0043434
IEA
Genome Projectresponse to peptide hormone
GO:0048553
ISS, ISO, IBA
IEA
Genome Projectnegative regulation of metalloenzyme activity
GO:0051045
ISO, IBA
IEA
Genome Projectnegative regulation of membrane protein ectodomain proteolysis
GO:0051216
IEA
Genome Projectcartilage development
GO:1901164
ISO
IEA
Genome Projectnegative regulation of trophoblast cell migration
GO:2001044
ISS, ISO
IEA
Genome Projectregulation of integrin-mediated signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0002020
IBA
IEA
Genome Projectprotease binding
GO:0004857
IEA
Genome Projectenzyme inhibitor activity
GO:0005125
ISS, ISO
IEA
Genome Projectcytokine activity
GO:0008083
IEA
Genome Projectgrowth factor activity
GO:0008191
ISS, ISO, IBA
IEA
Genome Projectmetalloendopeptidase inhibitor activity
GO:0030414
IEA
Genome Projectpeptidase inhibitor activity
GO:0046872
IEA
Genome Projectmetal ion binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
IEA
Genome Projectextracellular region
GO:0005578
IDA
Genome Projectproteinaceous extracellular matrix
GO:0005604
IDA
Genome Projectbasement membrane
GO:0005615
ISS, ISO, IBA
IEA
Genome Projectextracellular space
GO:0031012
IEA
Genome Projectextracellular matrix
GO:0070062
ISO
IEA
Genome Projectextracellular exosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001134Netrin domain
IPR001820Protease inhibitor I35 (TIMP)
IPR008993Tissue inhibitor of metalloproteinases-like, OB-fold
IPR015611Metalloproteinase inhibitor 1
IPR027465Proteinase inhibitor I35b (TIMP), C-terminal
IPR030490Tissue inhibitor of metalloproteinase, conserved site

No MapMan annotations defined for this gene.