Gene: ENSMUSG00000000441 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000000441
Transcript Identifier
ENSMUST00000000451
Gene Type
Coding gene
Location
6 : 115619266-115644616 : negative

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P012430
(7 genes in 4 species)
specific family
Duplication type
Tandem duplicate   and   Block duplicate

Descriptions

gene_descr
v-raf-leukemia viral oncogene 1

Identifiers

Type Value
UniprotQ99N57
MGI97847

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000165
IEA
Genome ProjectMAPK cascade
GO:0000186
ISO
IEA
Genome Projectactivation of MAPKK activity
GO:0001666
IEA
Genome Projectresponse to hypoxia
GO:0001678
IMP
Genome Projectcellular glucose homeostasis
GO:0001934
IMP
Genome Projectpositive regulation of protein phosphorylation
GO:0006468
IEA
Genome Projectprotein phosphorylation
GO:0007165
IEA
Genome Projectsignal transduction
GO:0007507
IEA
Genome Projectheart development
GO:0008285
ISO
IEA
Genome Projectnegative regulation of cell proliferation
GO:0016310
IEA
Genome Projectphosphorylation
GO:0030154
IGI
Genome Projectcell differentiation
GO:0031333
ISO
IEA
Genome Projectnegative regulation of protein complex assembly
GO:0033138
ISO
IEA
Genome Projectpositive regulation of peptidyl-serine phosphorylation
GO:0035019
IGI
Genome Projectsomatic stem cell population maintenance
GO:0035556
TAS, IEA
Genome Projectintracellular signal transduction
GO:0035773
IMP
Genome Projectinsulin secretion involved in cellular response to glucose stimulus
GO:0035994
IMP
Genome Projectresponse to muscle stretch
GO:0043066
ISO
IEA
Genome Projectnegative regulation of apoptotic process
GO:0045104
IMP
Genome Projectintermediate filament cytoskeleton organization
GO:0045944
IMP
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0048011
IMP
Genome Projectneurotrophin TRK receptor signaling pathway
GO:0071550
IMP
Genome Projectdeath-inducing signaling complex assembly
GO:1902042
IMP, IGI
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
TAS, IEA
Genome Projectprotein kinase activity
GO:0004674
ISO
IEA
Genome Projectprotein serine/threonine kinase activity
GO:0004709
IEA
Genome ProjectMAP kinase kinase kinase activity
GO:0005057
IEA
Genome Projectreceptor signaling protein activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0017016
IPI
Genome ProjectRas GTPase binding
GO:0031434
IEA
Genome Projectmitogen-activated protein kinase kinase binding
GO:0042802
ISO
IEA
Genome Projectidentical protein binding
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0046982
IEA
Genome Projectprotein heterodimerization activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IEA
Genome Projectnucleus
GO:0005737
ISS, ISO
IEA
Genome Projectcytoplasm
GO:0005739
IEA
Genome Projectmitochondrion
GO:0005794
ISO
IEA
Genome ProjectGolgi apparatus
GO:0005829
ISO
TAS, IEA
Genome Projectcytosol
GO:0005886
ISS, ISO
TAS, IEA
Genome Projectplasma membrane
GO:0016020
IEA
Genome Projectmembrane
GO:0031143
IDA
Genome Projectpseudopodium

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000719Protein kinase domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002219Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR003116Raf-like Ras-binding
IPR008271Serine/threonine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR017441Protein kinase, ATP binding site
IPR020454Diacylglycerol/phorbol-ester binding
IPR029071Ubiquitin-related domain

No MapMan annotations defined for this gene.