Gene: ENSMUSG00000000409 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000000409
Transcript Identifier
ENSMUST00000167288
Gene Type
Coding gene
Location
4 : 129548798-129558315 : negative

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P005517
(15 genes in 3 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
lymphocyte protein tyrosine kinase

Identifiers

Type Value
UniprotE9Q696
MGI96756

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0006468
IDA
ISO
IEA
Genome Projectprotein phosphorylation
GO:0006470
ISO
Genome Projectprotein dephosphorylation
GO:0006915
IEA
Genome Projectapoptotic process
GO:0006919
ISO
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007166
IDA
Genome Projectcell surface receptor signaling pathway
GO:0007169
IBA
Genome Projecttransmembrane receptor protein tyrosine kinase signaling pathway
GO:0007568
IEA
Genome Projectaging
GO:0009612
IEA
Genome Projectresponse to mechanical stimulus
GO:0010038
IEA
Genome Projectresponse to metal ion
GO:0010043
IEA
Genome Projectresponse to zinc ion
GO:0010628
IDA
Genome Projectpositive regulation of gene expression
GO:0016310
IEA
Genome Projectphosphorylation
GO:0016311
ISO
Genome Projectdephosphorylation
GO:0018108
IDA
IEA
Genome Projectpeptidyl-tyrosine phosphorylation
GO:0030217
ISO, IBA
Genome ProjectT cell differentiation
GO:0038083
IBA
Genome Projectpeptidyl-tyrosine autophosphorylation
GO:0042127
IBA
Genome Projectregulation of cell proliferation
GO:0042493
ISO
Genome Projectresponse to drug
GO:0042523
IDA
Genome Projectpositive regulation of tyrosine phosphorylation of Stat5 protein
GO:0042542
IEA
Genome Projectresponse to hydrogen peroxide
GO:0042981
IBA
Genome Projectregulation of apoptotic process
GO:0045087
IBA
Genome Projectinnate immune response
GO:0045588
IMP
Genome Projectpositive regulation of gamma-delta T cell differentiation
GO:0046777
IDA
IEA
Genome Projectprotein autophosphorylation
GO:0050853
IDA
Genome ProjectB cell receptor signaling pathway
GO:0050856
IDA
Genome Projectregulation of T cell receptor signaling pathway
GO:0050870
ISO
Genome Projectpositive regulation of T cell activation
GO:0070474
IEA
Genome Projectpositive regulation of uterine smooth muscle contraction
GO:0071375
IBA
Genome Projectcellular response to peptide hormone stimulus
GO:2001244
ISO
Genome Projectpositive regulation of intrinsic apoptotic signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0001948
ISO
IEA
Genome Projectglycoprotein binding
GO:0003823
IEA
Genome Projectantigen binding
GO:0004672
IEA
Genome Projectprotein kinase activity
GO:0004713
IDA, IMP
ISO
IEA
Genome Projectprotein tyrosine kinase activity
GO:0004715
IBA
IEA
Genome Projectnon-membrane spanning protein tyrosine kinase activity
GO:0004722
ISO
Genome Projectprotein serine/threonine phosphatase activity
GO:0005102
IBA
Genome Projectreceptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0008022
ISO
IEA
Genome Projectprotein C-terminus binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0019901
ISO
IEA
Genome Projectprotein kinase binding
GO:0019903
ISO
IEA
Genome Projectprotein phosphatase binding
GO:0032403
IEA
Genome Projectprotein complex binding
GO:0042169
ISO
Genome ProjectSH2 domain binding
GO:0042609
ISO
IEA
Genome ProjectCD4 receptor binding
GO:0042610
ISO
IEA
Genome ProjectCD8 receptor binding
GO:0042802
ISO
IEA
Genome Projectidentical protein binding
GO:0043548
ISO
IEA
Genome Projectphosphatidylinositol 3-kinase binding
GO:0051117
ISO
IEA
Genome ProjectATPase binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000242
ISO
Genome Projectpericentriolar material
GO:0001772
ISO
IEA
Genome Projectimmunological synapse
GO:0005886
ISO
IEA
Genome Projectplasma membrane
GO:0005911
IDA
Genome Projectcell-cell junction
GO:0030139
IEA
Genome Projectendocytic vesicle
GO:0031234
IBA
Genome Projectextrinsic component of cytoplasmic side of plasma membrane
GO:0045121
ISO
IEA
Genome Projectmembrane raft
GO:0070062
ISO
IEA
Genome Projectextracellular exosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000719Protein kinase domain
IPR000980SH2 domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001452SH3 domain
IPR008266Tyrosine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR017441Protein kinase, ATP binding site
IPR020635Tyrosine-protein kinase, catalytic domain

No MapMan annotations defined for this gene.