Gene: ENSMUSG00000000320 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000000320
Transcript Identifier
ENSMUST00000000329
Gene Type
Coding gene
Location
11 : 70242385-70255272 : negative

Family Information

Homologous gene family
HOM03P000704
(78 genes in 15 species)
specific family
Orthologous gene family
ORTHO03P000181
(65 genes in 15 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
arachidonate 12-lipoxygenase

Identifiers

Type Value
UniprotP39655
UniprotA2CF85
MGI87998

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0007568
IEA
Genome Projectaging
GO:0008284
IMP
ISO
IEA
Genome Projectpositive regulation of cell proliferation
GO:0010595
IEA
Genome Projectpositive regulation of endothelial cell migration
GO:0010628
IEA
Genome Projectpositive regulation of gene expression
GO:0010656
ISS, ISO
IEA
Genome Projectnegative regulation of muscle cell apoptotic process
GO:0010942
IEA
Genome Projectpositive regulation of cell death
GO:0019369
IDA, IMP
ISO
IEA
Genome Projectarachidonic acid metabolic process
GO:0019372
IDA, IMP
ISO
IEA
Genome Projectlipoxygenase pathway
GO:0019395
ISS, ISO
IEA
Genome Projectfatty acid oxidation
GO:0030307
ISS, ISO
IEA
Genome Projectpositive regulation of cell growth
GO:0030335
ISS, ISO
IEA
Genome Projectpositive regulation of cell migration
GO:0043065
ISS
IEA
Genome Projectpositive regulation of apoptotic process
GO:0043066
IMP
ISO
IEA
Genome Projectnegative regulation of apoptotic process
GO:0043280
IEA
Genome Projectpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043651
ISS
IEA
Genome Projectlinoleic acid metabolic process
GO:0045603
IEA
Genome Projectpositive regulation of endothelial cell differentiation
GO:0045766
ISS, ISO
IEA
Genome Projectpositive regulation of angiogenesis
GO:0045785
ISS, ISO
IEA
Genome Projectpositive regulation of cell adhesion
GO:0045909
IEA
Genome Projectpositive regulation of vasodilation
GO:0048661
IEA
Genome Projectpositive regulation of smooth muscle cell proliferation
GO:0051122
ISS
IEA
Genome Projecthepoxilin biosynthetic process
GO:0051901
IEA
Genome Projectpositive regulation of mitochondrial depolarization
GO:0055114
IEA
Genome Projectoxidation-reduction process
GO:0071396
IEA
Genome Projectcellular response to lipid
GO:1901751
ISS
IEA
Genome Projectleukotriene A4 metabolic process
GO:2001303
ISS, ISO
IEA
Genome Projectlipoxin A4 biosynthetic process
GO:2001306
ISS, ISO
IEA
Genome Projectlipoxin B4 biosynthetic process
GO:0006629
IEA
Genome Projectlipid metabolic process
GO:0006631
IEA
Genome Projectfatty acid metabolic process
GO:0006928
ISS
Genome Projectmovement of cell or subcellular component
GO:0061436
IMP
Genome Projectestablishment of skin barrier
GO:0090331
IMP
Genome Projectnegative regulation of platelet aggregation

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004052
IDA
ISS, ISO
IEA
Genome Projectarachidonate 12-lipoxygenase activity
GO:0005506
IEA
Genome Projectiron ion binding
GO:0016165
ISO
IEA
Genome Projectlinoleate 13S-lipoxygenase activity
GO:0016491
IEA
Genome Projectoxidoreductase activity
GO:0016702
IEA
Genome Projectoxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0051213
IEA
Genome Projectdioxygenase activity
GO:0016787
IEA
Genome Projecthydrolase activity
GO:0047977
ISS
Genome Projecthepoxilin-epoxide hydrolase activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
IDA
ISO
IEA
Genome Projectcytoplasm
GO:0005829
ISO
IEA
Genome Projectcytosol
GO:0016020
ISS, ISO
IEA
Genome Projectmembrane
GO:0042383
ISS, ISO
IEA
Genome Projectsarcolemma
GO:0070062
ISO
IEA
Genome Projectextracellular exosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000907Lipoxygenase
IPR001024PLAT/LH2 domain
IPR001885Lipoxygenase, mammalian
IPR013819Lipoxygenase, C-terminal
IPR020833Lipoxygenase, iron binding site
IPR020834Lipoxygenase, conserved site

No MapMan annotations defined for this gene.