Gene: ENSG00000259207 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000259207
Transcript Identifier
ENST00000559488
Gene Type
Coding gene
Location
17 : 47253862-47310204 : positive

Family Information

Homologous gene family
HOM03P005934
(15 genes in 4 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)

Identifiers

Type Value
pidENSP00000452786
HGNC6156
UniprotP05106

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001934
TAS
Genome Projectpositive regulation of protein phosphorylation
GO:0001938
IMP
Genome Projectpositive regulation of endothelial cell proliferation
GO:0002576
TAS
Genome Projectplatelet degranulation
GO:0006457
IDA
Genome Projectprotein folding
GO:0007044
IEA
Genome Projectcell-substrate junction assembly
GO:0007155
TAS, IEA
Genome Projectcell adhesion
GO:0007160
IDA, IMP
IEA
Genome Projectcell-matrix adhesion
GO:0007229
IDA
TAS, IEA
Genome Projectintegrin-mediated signaling pathway
GO:0007411
TAS
Genome Projectaxon guidance
GO:0007596
TAS
Genome Projectblood coagulation
GO:0010595
IMP
Genome Projectpositive regulation of endothelial cell migration
GO:0010745
IMP
Genome Projectnegative regulation of macrophage derived foam cell differentiation
GO:0010888
IMP
Genome Projectnegative regulation of lipid storage
GO:0014909
IMP
Genome Projectsmooth muscle cell migration
GO:0016032
IEA
Genome Projectviral process
GO:0016049
IMP
Genome Projectcell growth
GO:0016477
IMP
Genome Projectcell migration
GO:0030168
IMP
TAS
Genome Projectplatelet activation
GO:0030198
TAS
Genome Projectextracellular matrix organization
GO:0030334
IEA
Genome Projectregulation of cell migration
GO:0030949
TAS
Genome Projectpositive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031589
IMP
Genome Projectcell-substrate adhesion
GO:0032147
IMP
Genome Projectactivation of protein kinase activity
GO:0032369
IMP
Genome Projectnegative regulation of lipid transport
GO:0034113
IMP
Genome Projectheterotypic cell-cell adhesion
GO:0034446
IDA
Genome Projectsubstrate adhesion-dependent cell spreading
GO:0035295
TAS
Genome Projecttube development
GO:0038027
IMP
Genome Projectapolipoprotein A-I-mediated signaling pathway
GO:0042060
IC
Genome Projectwound healing
GO:0045124
TAS
Genome Projectregulation of bone resorption
GO:0045715
IMP
Genome Projectnegative regulation of low-density lipoprotein particle receptor biosynthetic process
GO:0046718
IMP
Genome Projectviral entry into host cell
GO:0048010
TAS
Genome Projectvascular endothelial growth factor receptor signaling pathway
GO:0048333
IEP
Genome Projectmesodermal cell differentiation
GO:0050731
IMP
Genome Projectpositive regulation of peptidyl-tyrosine phosphorylation
GO:0050748
IMP
Genome Projectnegative regulation of lipoprotein metabolic process
GO:0050900
TAS
Genome Projectleukocyte migration
GO:0050919
IMP
Genome Projectnegative chemotaxis
GO:0060055
TAS, IEA
Genome Projectangiogenesis involved in wound healing
GO:0070527
IMP
IEA
Genome Projectplatelet aggregation

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001968
IMP
Genome Projectfibronectin binding
GO:0002020
IDA
Genome Projectprotease binding
GO:0003756
IDA
Genome Projectprotein disulfide isomerase activity
GO:0004872
IEA
Genome Projectreceptor activity
GO:0005161
TAS
Genome Projectplatelet-derived growth factor receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0019899
IPI
Genome Projectenzyme binding
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0043184
IPI
TAS
Genome Projectvascular endothelial growth factor receptor 2 binding
GO:0050839
IPI
Genome Projectcell adhesion molecule binding
GO:0050840
IDA
Genome Projectextracellular matrix binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
Genome Projectnucleus
GO:0005886
IDA
TAS, IEA
Genome Projectplasma membrane
GO:0005887
TAS
Genome Projectintegral component of plasma membrane
GO:0005925
IDA
IEA
Genome Projectfocal adhesion
GO:0008305
IDA
TAS, IEA
Genome Projectintegrin complex
GO:0009986
IDA
Genome Projectcell surface
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0030054
IEA
Genome Projectcell junction
GO:0031092
TAS
Genome Projectplatelet alpha granule membrane
GO:0031258
IDA
IEA
Genome Projectlamellipodium membrane
GO:0031527
IDA
Genome Projectfilopodium membrane
GO:0031528
IDA
Genome Projectmicrovillus membrane
GO:0032587
IDA
Genome Projectruffle membrane
GO:0034683
IDA
Genome Projectintegrin alphav-beta3 complex
GO:0042470
IDA
Genome Projectmelanosome
GO:0042995
IEA
Genome Projectcell projection
GO:0043235
IDA
Genome Projectreceptor complex
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0071062
TAS
Genome Projectalphav-beta3 integrin-vitronectin complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR002035von Willebrand factor, type A
IPR002369Integrin beta subunit, N-terminal
IPR012896Integrin beta subunit, tail
IPR013111EGF-like domain, extracellular
IPR014836Integrin beta subunit, cytoplasmic domain
IPR015812Integrin beta subunit
IPR016201Plexin-like fold
IPR027068Integrin beta-3 subunit

No MapMan annotations defined for this gene.