Gene: ENSG00000254647 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000254647
Transcript Identifier
ENST00000381330
Gene Type
Coding gene
Location
11 : 2159852-2160971 : negative

Family Information

Homologous gene family
HOM03P022471
(4 genes in 2 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
insulin

Identifiers

Type Value
pidENSP00000370731
HGNC6081
UniprotP01308
UniprotI3WAC9

Toolbox

Explore

Create

View

Browse

 

Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005975
IEA
Genome Projectcarbohydrate metabolic process
GO:0006006
IEA
Genome Projectglucose metabolic process
GO:0000165
IDA
Genome ProjectMAPK cascade
GO:0002674
IDA
Genome Projectnegative regulation of acute inflammatory response
GO:0006112
TAS
Genome Projectenergy reserve metabolic process
GO:0006355
NAS
Genome Projectregulation of transcription, DNA-templated
GO:0006521
IMP
Genome Projectregulation of cellular amino acid metabolic process
GO:0006953
IDA
Genome Projectacute-phase response
GO:0007186
IDA
Genome ProjectG-protein coupled receptor signaling pathway
GO:0007267
IC
Genome Projectcell-cell signaling
GO:0008284
IDA
Genome Projectpositive regulation of cell proliferation
GO:0008286
IDA
TAS
Genome Projectinsulin receptor signaling pathway
GO:0014068
IDA
Genome Projectpositive regulation of phosphatidylinositol 3-kinase signaling
GO:0015758
IDA
Genome Projectglucose transport
GO:0022898
IDA
Genome Projectregulation of transmembrane transporter activity
GO:0030307
NAS
Genome Projectpositive regulation of cell growth
GO:0030335
ISS
Genome Projectpositive regulation of cell migration
GO:0031018
TAS
Genome Projectendocrine pancreas development
GO:0031954
ISS
Genome Projectpositive regulation of protein autophosphorylation
GO:0032148
IDA
Genome Projectactivation of protein kinase B activity
GO:0032270
IMP
Genome Projectpositive regulation of cellular protein metabolic process
GO:0032460
IDA
Genome Projectnegative regulation of protein oligomerization
GO:0032880
IDA
Genome Projectregulation of protein localization
GO:0033861
IDA
Genome Projectnegative regulation of NAD(P)H oxidase activity
GO:0042060
IDA
Genome Projectwound healing
GO:0042177
IDA
Genome Projectnegative regulation of protein catabolic process
GO:0042593
IMP
Genome Projectglucose homeostasis
GO:0043410
IDA
Genome Projectpositive regulation of MAPK cascade
GO:0044267
TAS
Genome Projectcellular protein metabolic process
GO:0044281
TAS
Genome Projectsmall molecule metabolic process
GO:0045429
NAS
Genome Projectpositive regulation of nitric oxide biosynthetic process
GO:0045597
NAS
Genome Projectpositive regulation of cell differentiation
GO:0045721
NAS
Genome Projectnegative regulation of gluconeogenesis
GO:0045725
IDA
Genome Projectpositive regulation of glycogen biosynthetic process
GO:0045740
IDA
Genome Projectpositive regulation of DNA replication
GO:0045818
IMP
Genome Projectnegative regulation of glycogen catabolic process
GO:0045821
IDA, IMP
Genome Projectpositive regulation of glycolytic process
GO:0045840
IDA
Genome Projectpositive regulation of mitotic nuclear division
GO:0045861
IMP
Genome Projectnegative regulation of proteolysis
GO:0045908
NAS
Genome Projectnegative regulation of vasodilation
GO:0045909
NAS
Genome Projectpositive regulation of vasodilation
GO:0045922
IMP
Genome Projectnegative regulation of fatty acid metabolic process
GO:0046326
IDA
Genome Projectpositive regulation of glucose import
GO:0046628
IDA
Genome Projectpositive regulation of insulin receptor signaling pathway
GO:0046631
IDA
Genome Projectalpha-beta T cell activation
GO:0046889
NAS
Genome Projectpositive regulation of lipid biosynthetic process
GO:0050708
IDA
Genome Projectregulation of protein secretion
GO:0050709
IDA
Genome Projectnegative regulation of protein secretion
GO:0050715
IDA
Genome Projectpositive regulation of cytokine secretion
GO:0050731
IDA
Genome Projectpositive regulation of peptidyl-tyrosine phosphorylation
GO:0050796
TAS
Genome Projectregulation of insulin secretion
GO:0050995
IMP
NAS
Genome Projectnegative regulation of lipid catabolic process
GO:0051000
NAS
Genome Projectpositive regulation of nitric-oxide synthase activity
GO:0051092
IDA
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0051897
IDA
Genome Projectpositive regulation of protein kinase B signaling
GO:0055089
IMP
Genome Projectfatty acid homeostasis
GO:0060266
IDA
Genome Projectnegative regulation of respiratory burst involved in inflammatory response
GO:0060267
IDA
Genome Projectpositive regulation of respiratory burst
GO:0090277
TAS
Genome Projectpositive regulation of peptide hormone secretion
GO:0090336
TAS
Genome Projectpositive regulation of brown fat cell differentiation
GO:1900182
IDA
Genome Projectpositive regulation of protein localization to nucleus
GO:1902176
NAS
Genome Projectnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:2000252
IDA
Genome Projectnegative regulation of feeding behavior

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005179
IMP
NAS, IC, IEA
Genome Projecthormone activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0002020
IPI
Genome Projectprotease binding
GO:0005158
IDA, IPI
Genome Projectinsulin receptor binding
GO:0005159
IPI
Genome Projectinsulin-like growth factor receptor binding
GO:0042802
IPI
Genome Projectidentical protein binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
TAS, IC, IEA
Genome Projectextracellular region
GO:0005615
IDA
Genome Projectextracellular space
GO:0005788
TAS
Genome Projectendoplasmic reticulum lumen
GO:0005796
TAS
Genome ProjectGolgi lumen
GO:0031904
TAS
Genome Projectendosome lumen
GO:0034774
TAS
Genome Projectsecretory granule lumen

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR004825Insulin
IPR016179Insulin-like
IPR022352Insulin family
IPR022353Insulin, conserved site

No MapMan annotations defined for this gene.