Gene: ENSG00000253729 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000253729
Transcript Identifier
ENST00000314191
Gene Type
Coding gene
Location
8 : 47774173-47960126 : negative

Family Information

Homologous gene family
HOM03P000164
(189 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P003812
(22 genes in 19 species)
specific family

Descriptions

gene_descr
protein kinase, DNA-activated, catalytic polypeptide

Identifiers

Type Value
pidENSP00000313420
HGNC9413
UniprotP78527

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000723
IEA
Genome Projecttelomere maintenance
GO:0000724
IBA
Genome Projectdouble-strand break repair via homologous recombination
GO:0001756
IEA
Genome Projectsomitogenesis
GO:0001933
ISS
IEA
Genome Projectnegative regulation of protein phosphorylation
GO:0002326
IEA
Genome ProjectB cell lineage commitment
GO:0002328
IEA
Genome Projectpro-B cell differentiation
GO:0002360
IEA
Genome ProjectT cell lineage commitment
GO:0002377
IEA
Genome Projectimmunoglobulin production
GO:0002638
IEA
Genome Projectnegative regulation of immunoglobulin production
GO:0002684
IEA
Genome Projectpositive regulation of immune system process
GO:0006281
TAS, IEA
Genome ProjectDNA repair
GO:0006302
TAS, IEA
Genome Projectdouble-strand break repair
GO:0006303
TAS, IEA
Genome Projectdouble-strand break repair via nonhomologous end joining
GO:0006310
IEA
Genome ProjectDNA recombination
GO:0006464
TAS
Genome Projectcellular protein modification process
GO:0006974
IEA
Genome Projectcellular response to DNA damage stimulus
GO:0007420
IEA
Genome Projectbrain development
GO:0007507
IEA
Genome Projectheart development
GO:0008630
IEA
Genome Projectintrinsic apoptotic signaling pathway in response to DNA damage
GO:0010212
IEA
Genome Projectresponse to ionizing radiation
GO:0010332
IEA
Genome Projectresponse to gamma radiation
GO:0014823
IEA
Genome Projectresponse to activity
GO:0016310
IEA
Genome Projectphosphorylation
GO:0018105
IDA
Genome Projectpeptidyl-serine phosphorylation
GO:0030098
IEA
Genome Projectlymphocyte differentiation
GO:0031648
IEA
Genome Projectprotein destabilization
GO:0032481
TAS
Genome Projectpositive regulation of type I interferon production
GO:0032869
IMP
Genome Projectcellular response to insulin stimulus
GO:0033077
IEA
Genome ProjectT cell differentiation in thymus
GO:0033151
IEA
Genome ProjectV(D)J recombination
GO:0033152
IEA
Genome Projectimmunoglobulin V(D)J recombination
GO:0033153
IEA
Genome ProjectT cell receptor V(D)J recombination
GO:0035234
IEA
Genome Projectectopic germ cell programmed cell death
GO:0042752
ISS
IEA
Genome Projectregulation of circadian rhythm
GO:0043065
IEA
Genome Projectpositive regulation of apoptotic process
GO:0043066
IMP
Genome Projectnegative regulation of apoptotic process
GO:0045087
TAS
Genome Projectinnate immune response
GO:0045944
IMP
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0048146
IEA
Genome Projectpositive regulation of fibroblast proliferation
GO:0048511
IEA
Genome Projectrhythmic process
GO:0048536
IEA
Genome Projectspleen development
GO:0048538
IEA
Genome Projectthymus development
GO:0048639
IEA
Genome Projectpositive regulation of developmental growth
GO:0048660
IMP
Genome Projectregulation of smooth muscle cell proliferation
GO:0072431
IMP
Genome Projectsignal transduction involved in mitotic G1 DNA damage checkpoint
GO:2000773
IEA
Genome Projectnegative regulation of cellular senescence
GO:2001229
IEA
Genome Projectnegative regulation of response to gamma radiation

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0003677
IEA
Genome ProjectDNA binding
GO:0003690
IEA
Genome Projectdouble-stranded DNA binding
GO:0004672
IDA
TAS
Genome Projectprotein kinase activity
GO:0004674
IDA
IEA
Genome Projectprotein serine/threonine kinase activity
GO:0004677
IDA
IEA
Genome ProjectDNA-dependent protein kinase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0008134
IPI
Genome Projecttranscription factor binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0016773
IEA
Genome Projectphosphotransferase activity, alcohol group as acceptor
GO:0019899
IEA
Genome Projectenzyme binding
GO:0044822
IDA
Genome Projectpoly(A) RNA binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000784
IDA
Genome Projectnuclear chromosome, telomeric region
GO:0005634
IEA
Genome Projectnucleus
GO:0005654
IDA
TAS
Genome Projectnucleoplasm
GO:0005667
IDA
Genome Projecttranscription factor complex
GO:0005730
IEA
Genome Projectnucleolus
GO:0005829
TAS
Genome Projectcytosol
GO:0005958
IDA
Genome ProjectDNA-dependent protein kinase-DNA ligase 4 complex
GO:0016020
IDA
Genome Projectmembrane
GO:0070419
IDA
Genome Projectnonhomologous end joining complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000403Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR003151PIK-related kinase, FAT
IPR003152FATC domain
IPR011009Protein kinase-like domain
IPR011989Armadillo-like helical
IPR012582NUC194
IPR014009PIK-related kinase
IPR016024Armadillo-type fold
IPR018936Phosphatidylinositol 3/4-kinase, conserved site

No MapMan annotations defined for this gene.