Gene: ENSG00000230254 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000230254
Transcript Identifier
ENST00000427936
Gene Type
Coding gene
Location
CHR_HSCHR6_MHC_SSTO_CTG1 : 1790301-1793350 : positive

Family Information

Homologous gene family
HOM03P000618
(85 genes in 2 species)
specific family
Orthologous gene family
ORTHO03P000429
(50 genes in 2 species)
specific family
Duplication type
Tandem duplicate   and   Block duplicate

Descriptions

gene_descr
major histocompatibility complex, class I, E

Identifiers

Type Value
pidENSP00000397420
HGNC4962
UniprotP13747
UniprotQ6DU50

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001916
IDA
Genome Projectpositive regulation of T cell mediated cytotoxicity
GO:0002250
IDA
Genome Projectadaptive immune response
GO:0002376
IEA
Genome Projectimmune system process
GO:0002474
IBA
TAS, IEA
Genome Projectantigen processing and presentation of peptide antigen via MHC class I
GO:0002476
IDA
Genome Projectantigen processing and presentation of endogenous peptide antigen via MHC class Ib
GO:0002479
TAS
Genome Projectantigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002480
TAS
Genome Projectantigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
GO:0002715
IDA
Genome Projectregulation of natural killer cell mediated immunity
GO:0002717
IDA
Genome Projectpositive regulation of natural killer cell mediated immunity
GO:0006955
IEA
Genome Projectimmune response
GO:0019221
TAS
Genome Projectcytokine-mediated signaling pathway
GO:0019731
IDA
Genome Projectantibacterial humoral response
GO:0019882
IEA
Genome Projectantigen processing and presentation
GO:0032736
IDA
Genome Projectpositive regulation of interleukin-13 production
GO:0032753
IDA
Genome Projectpositive regulation of interleukin-4 production
GO:0032759
IDA
Genome Projectpositive regulation of TRAIL production
GO:0032760
IDA
Genome Projectpositive regulation of tumor necrosis factor production
GO:0036037
IDA
Genome ProjectCD8-positive, alpha-beta T cell activation
GO:0042270
IDA
Genome Projectprotection from natural killer cell mediated cytotoxicity
GO:0042590
TAS
Genome Projectantigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0045087
TAS
Genome Projectinnate immune response
GO:0050776
TAS
Genome Projectregulation of immune response
GO:0050830
IDA
Genome Projectdefense response to Gram-positive bacterium
GO:0051024
IDA
Genome Projectpositive regulation of immunoglobulin secretion
GO:0060333
TAS
Genome Projectinterferon-gamma-mediated signaling pathway
GO:0060337
TAS
Genome Projecttype I interferon signaling pathway
GO:2000566
IDA
Genome Projectpositive regulation of CD8-positive, alpha-beta T cell proliferation

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005102
IPI
Genome Projectreceptor binding
GO:0030881
IDA, IMP
Genome Projectbeta-2-microglobulin binding
GO:0042288
IDA
Genome ProjectMHC class I protein binding
GO:0042605
IDA, IMP
IEA
Genome Projectpeptide antigen binding
GO:0046703
IPI
Genome Projectnatural killer cell lectin-like receptor binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000139
TAS
Genome ProjectGolgi membrane
GO:0005886
TAS
Genome Projectplasma membrane
GO:0009986
IDA
Genome Projectcell surface
GO:0012507
TAS
Genome ProjectER to Golgi transport vesicle membrane
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0030670
TAS
Genome Projectphagocytic vesicle membrane
GO:0031901
TAS
Genome Projectearly endosome membrane
GO:0032398
IDA
Genome ProjectMHC class Ib protein complex
GO:0042612
IDA
IEA
Genome ProjectMHC class I protein complex
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0071556
TAS
Genome Projectintegral component of lumenal side of endoplasmic reticulum membrane

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001039MHC class I alpha chain, alpha1 alpha2 domains
IPR003006Immunoglobulin/major histocompatibility complex, conserved site
IPR003597Immunoglobulin C1-set
IPR007110Immunoglobulin-like domain
IPR010579MHC class I, alpha chain, C-terminal
IPR011161MHC class I-like antigen recognition-like
IPR011162MHC classes I/II-like antigen recognition protein
IPR013783Immunoglobulin-like fold
IPR027648MHC class I alpha chain

No MapMan annotations defined for this gene.