Gene: ENSG00000230108 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000230108
Transcript Identifier
ENST00000443707
Gene Type
Coding gene
Location
CHR_HSCHR6_MHC_SSTO_CTG1 : 2875022-2876817 : positive

Family Information

Homologous gene family
HOM03P006776
(13 genes in 2 species)
specific family
Orthologous gene family
ORTHO03P010000
(8 genes in 2 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
tumor necrosis factor

Identifiers

Type Value
pidENSP00000389492
HGNC11892
UniprotP01375
UniprotQ5STB3

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000060
IDA
Genome Projectprotein import into nucleus, translocation
GO:0000122
IDA
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0000165
IMP
Genome ProjectMAPK cascade
GO:0000185
IDA
Genome Projectactivation of MAPKKK activity
GO:0000187
IDA
Genome Projectactivation of MAPK activity
GO:0001819
IDA
Genome Projectpositive regulation of cytokine production
GO:0001932
IEA
Genome Projectregulation of protein phosphorylation
GO:0001934
IDA
Genome Projectpositive regulation of protein phosphorylation
GO:0002439
IMP
Genome Projectchronic inflammatory response to antigenic stimulus
GO:0002740
IDA
Genome Projectnegative regulation of cytokine secretion involved in immune response
GO:0002876
IEA
Genome Projectpositive regulation of chronic inflammatory response to antigenic stimulus
GO:0002925
IEA
Genome Projectpositive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0006006
IEA
Genome Projectglucose metabolic process
GO:0006919
IDA
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006927
IDA
Genome Projecttransformed cell apoptotic process
GO:0006952
IEA
Genome Projectdefense response
GO:0006954
IDA
Genome Projectinflammatory response
GO:0006955
IEA
Genome Projectimmune response
GO:0006959
IEA
Genome Projecthumoral immune response
GO:0007166
TAS
Genome Projectcell surface receptor signaling pathway
GO:0007254
IEA
Genome ProjectJNK cascade
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0008625
IDA
NAS
Genome Projectextrinsic apoptotic signaling pathway via death domain receptors
GO:0008630
IEA
Genome Projectintrinsic apoptotic signaling pathway in response to DNA damage
GO:0009615
IDA
Genome Projectresponse to virus
GO:0009651
TAS
Genome Projectresponse to salt stress
GO:0009887
IEA
Genome Projectorgan morphogenesis
GO:0010628
IDA, IMP
Genome Projectpositive regulation of gene expression
GO:0010629
IDA
Genome Projectnegative regulation of gene expression
GO:0010693
IEA
Genome Projectnegative regulation of alkaline phosphatase activity
GO:0010888
NAS
Genome Projectnegative regulation of lipid storage
GO:0030198
IEA
Genome Projectextracellular matrix organization
GO:0030316
IEA
Genome Projectosteoclast differentiation
GO:0030730
IDA
Genome Projectsequestering of triglyceride
GO:0031334
IDA
Genome Projectpositive regulation of protein complex assembly
GO:0031622
ISS
IEA
Genome Projectpositive regulation of fever generation
GO:0031663
IDA
Genome Projectlipopolysaccharide-mediated signaling pathway
GO:0032715
IDA
Genome Projectnegative regulation of interleukin-6 production
GO:0032722
IDA
Genome Projectpositive regulation of chemokine production
GO:0032729
IEA
Genome Projectpositive regulation of interferon-gamma production
GO:0032755
IEA
Genome Projectpositive regulation of interleukin-6 production
GO:0032757
IMP
Genome Projectpositive regulation of interleukin-8 production
GO:0032800
IDA
Genome Projectreceptor biosynthetic process
GO:0033138
IDA
Genome Projectpositive regulation of peptidyl-serine phosphorylation
GO:0033209
IMP
TAS
Genome Projecttumor necrosis factor-mediated signaling pathway
GO:0034116
IDA
Genome Projectpositive regulation of heterotypic cell-cell adhesion
GO:0042127
IEA
Genome Projectregulation of cell proliferation
GO:0042346
IDA
Genome Projectpositive regulation of NF-kappaB import into nucleus
GO:0042742
IEA
Genome Projectdefense response to bacterium
GO:0043065
IDA
Genome Projectpositive regulation of apoptotic process
GO:0043068
IDA
Genome Projectpositive regulation of programmed cell death
GO:0043122
IDA
Genome Projectregulation of I-kappaB kinase/NF-kappaB signaling
GO:0043123
IDA
Genome Projectpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043242
IDA
Genome Projectnegative regulation of protein complex disassembly
GO:0043243
IDA
Genome Projectpositive regulation of protein complex disassembly
GO:0043280
IDA
Genome Projectpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043406
IDA
Genome Projectpositive regulation of MAP kinase activity
GO:0043491
IMP
Genome Projectprotein kinase B signaling
GO:0043507
IDA
Genome Projectpositive regulation of JUN kinase activity
GO:0044130
IEA
Genome Projectnegative regulation of growth of symbiont in host
GO:0045071
IDA
Genome Projectnegative regulation of viral genome replication
GO:0045080
IDA
Genome Projectpositive regulation of chemokine biosynthetic process
GO:0045123
IEA
Genome Projectcellular extravasation
GO:0045416
IDA
Genome Projectpositive regulation of interleukin-8 biosynthetic process
GO:0045429
IDA
Genome Projectpositive regulation of nitric oxide biosynthetic process
GO:0045599
NAS
Genome Projectnegative regulation of fat cell differentiation
GO:0045662
IEA
Genome Projectnegative regulation of myoblast differentiation
GO:0045668
IEA
Genome Projectnegative regulation of osteoblast differentiation
GO:0045670
IEA
Genome Projectregulation of osteoclast differentiation
GO:0045672
IDA
Genome Projectpositive regulation of osteoclast differentiation
GO:0045785
IMP
Genome Projectpositive regulation of cell adhesion
GO:0045860
IDA
Genome Projectpositive regulation of protein kinase activity
GO:0045892
IDA
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045893
IDA
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045944
IDA, IGI
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0045994
IEA
Genome Projectpositive regulation of translational initiation by iron
GO:0046325
IEA
Genome Projectnegative regulation of glucose import
GO:0046330
IEA
Genome Projectpositive regulation of JNK cascade
GO:0048566
IEP
Genome Projectembryonic digestive tract development
GO:0048661
IDA
Genome Projectpositive regulation of smooth muscle cell proliferation
GO:0050708
IEA
Genome Projectregulation of protein secretion
GO:0050715
IDA
Genome Projectpositive regulation of cytokine secretion
GO:0050766
IMP
Genome Projectpositive regulation of phagocytosis
GO:0050796
IDA
Genome Projectregulation of insulin secretion
GO:0050830
IEA
Genome Projectdefense response to Gram-positive bacterium
GO:0050900
IEA
Genome Projectleukocyte migration
GO:0050901
IDA
Genome Projectleukocyte tethering or rolling
GO:0050995
IDA
Genome Projectnegative regulation of lipid catabolic process
GO:0051023
IEA
Genome Projectregulation of immunoglobulin secretion
GO:0051044
IDA
Genome Projectpositive regulation of membrane protein ectodomain proteolysis
GO:0051091
IDA
Genome Projectpositive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092
IDA, IMP
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0051222
IDA
Genome Projectpositive regulation of protein transport
GO:0051384
IDA
Genome Projectresponse to glucocorticoid
GO:0051533
IDA
Genome Projectpositive regulation of NFAT protein import into nucleus
GO:0051798
IEA
Genome Projectpositive regulation of hair follicle development
GO:0051897
IEA
Genome Projectpositive regulation of protein kinase B signaling
GO:0060557
IDA
Genome Projectpositive regulation of vitamin D biosynthetic process
GO:0060559
IDA
Genome Projectpositive regulation of calcidiol 1-monooxygenase activity
GO:0060664
IEA
Genome Projectepithelial cell proliferation involved in salivary gland morphogenesis
GO:0060693
IEA
Genome Projectregulation of branching involved in salivary gland morphogenesis
GO:0061048
IDA
Genome Projectnegative regulation of branching involved in lung morphogenesis
GO:0070374
NAS
Genome Projectpositive regulation of ERK1 and ERK2 cascade
GO:0071222
IEA
Genome Projectcellular response to lipopolysaccharide
GO:0071230
IEA
Genome Projectcellular response to amino acid stimulus
GO:0071316
IDA
Genome Projectcellular response to nicotine
GO:0071407
IDA
Genome Projectcellular response to organic cyclic compound
GO:0071550
TAS
Genome Projectdeath-inducing signaling complex assembly
GO:0071677
NAS
Genome Projectpositive regulation of mononuclear cell migration
GO:0071803
IDA
Genome Projectpositive regulation of podosome assembly
GO:0097190
IEA
Genome Projectapoptotic signaling pathway
GO:0097191
IDA
Genome Projectextrinsic apoptotic signaling pathway
GO:0097527
IDA
Genome Projectnecroptotic signaling pathway
GO:2000010
IDA
Genome Projectpositive regulation of protein localization to cell surface
GO:2000343
IDA
Genome Projectpositive regulation of chemokine (C-X-C motif) ligand 2 production
GO:2000377
IEA
Genome Projectregulation of reactive oxygen species metabolic process
GO:2001240
IDA
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0002020
IPI
Genome Projectprotease binding
GO:0005125
IDA
IEA
Genome Projectcytokine activity
GO:0005164
IDA
IEA
Genome Projecttumor necrosis factor receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0042802
IDA
Genome Projectidentical protein binding
GO:0044212
IDA
Genome Projecttranscription regulatory region DNA binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001891
ISS
IEA
Genome Projectphagocytic cup
GO:0005576
TAS, IEA
Genome Projectextracellular region
GO:0005615
IDA
IEA
Genome Projectextracellular space
GO:0005622
IEA
Genome Projectintracellular
GO:0005886
TAS, IEA
Genome Projectplasma membrane
GO:0005887
IDA
Genome Projectintegral component of plasma membrane
GO:0009897
ISS
IEA
Genome Projectexternal side of plasma membrane
GO:0009986
IDA
Genome Projectcell surface
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0045121
IDA
Genome Projectmembrane raft
GO:0055037
ISS
IEA
Genome Projectrecycling endosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR002959Tumour necrosis factor alpha
IPR006052Tumour necrosis factor domain
IPR006053Tumour necrosis factor
IPR008983Tumour necrosis factor-like domain
IPR021184Tumour necrosis factor, conserved site

No MapMan annotations defined for this gene.